2.4.1.47: N-acylsphingosine galactosyltransferase

This is an abbreviated version!
For detailed information about N-acylsphingosine galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.47

2.4.1.47

myelin

oligodendrocyte

sulfatide

udp-galactose:ceramide

galactosylceramide

galactocerebroside

galcer

2.4.1.45

myelin-specific

3'-phosphohydrolase

3'-phosphodiesterase

myelin-related

sulfoglycolipids

udp-glucose:ceramide

galactosphingolipids

paranodal

medicine

Reaction

Synonyms

ceramide galactosyltransferase, cerebroside synthase, CGalT, CGT, EC 2.4.1.45, galactosyltransferase, uridine diphosphogalactose-2-hydroxyacylsphingosine, galactosyltransferase, uridine diphosphogalactose-acylsphingosine, GALT, UDP galactose-N-acylsphingosine galactosyltransferase, UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase, UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase, UDPgalactose:ceramide galactosyltransferase, UGT8, uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase, uridine diphosphogalactose-acylsphingosine galactosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.47 N-acylsphingosine galactosyltransferase

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Results	in table
7	Activating Compound
15	AA Sequence
2	Application
2	CAS Registry Number
12	Cloned(Commentary)
1	Crystallization (Commentary)
48	Disease/ Diagnostics
2	Expression
6	General Stability
14	Inhibitors
5	KM Value [mM]
20	Localization
12	Metals/Ions
7	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
27	Organism
4	Pathway
4	pH Optimum
11	Posttranslational Modification
2	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
25	Reference
34	Source Tissue
4	Specific Activity [micromol/min/mg]
4	Storage Stability
43	Substrates and Products (Substrate)
6	Subunits
18	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 2.4.1.47 - N-acylsphingosine galactosyltransferase

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Detergents

2 entries

DL-sphingosine

2 entries

Octanoyl-D-threo-p-nitro-1-phenyl-2-amino-1,3-propanediol

Rattus norvegicus

489216

Phospholipase A

Rattus norvegicus

almost complete inactivation

Phospholipase C

56% loss of activity

Protein inhibitor

from brain, kidney, spleen and liver of rat and other animals

sodium deoxycholate

strong inhibition

sodium taurocholate

strong inhibition

sodium taurodeoxycholate

strong inhibition

zoledronate

optimal inhibitor of human ceramide galactosyltransferase, showing a favorable steric hindrance factor in contrast to other inhibitors or UDP-gal. It exhibits binding sites distributed homogeneously that can bind simultaneously

757464

additional information

Rattus norvegicus

nutritional inadequacy during the active growth phase of the brain causes significantly diminished enzyme activity

489223