2.4.1.47: N-acylsphingosine galactosyltransferase

This is an abbreviated version!
For detailed information about N-acylsphingosine galactosyltransferase, go to the full flat file.

Reaction

Synonyms

ceramide galactosyltransferase, cerebroside synthase, CGalT, CGT, EC 2.4.1.45, galactosyltransferase, uridine diphosphogalactose-2-hydroxyacylsphingosine, galactosyltransferase, uridine diphosphogalactose-acylsphingosine, GALT, UDP galactose-N-acylsphingosine galactosyltransferase, UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase, UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase, UDPgalactose:ceramide galactosyltransferase, UGT8, uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase, uridine diphosphogalactose-acylsphingosine galactosyltransferase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.1 Hexosyltransferases

                2.4.1.47 N-acylsphingosine galactosyltransferase

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Results	in table
7	Activating Compound
15	AA Sequence
2	Application
2	CAS Registry Number
12	Cloned(Commentary)
1	Crystallization (Commentary)
48	Disease/ Diagnostics
2	Expression
6	General Stability
14	Inhibitors
5	KM Value [mM]
20	Localization
12	Metals/Ions
7	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
27	Organism
4	Pathway
4	pH Optimum
11	Posttranslational Modification
2	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
25	Reference
34	Source Tissue
4	Specific Activity [micromol/min/mg]
4	Storage Stability
43	Substrates and Products (Substrate)
6	Subunits
18	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]

Substrates Products

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of the Enzyme Summary Page.

Substrates Products on EC 2.4.1.47 - N-acylsphingosine galactosyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

UDP-galactose + ceramide

UDP + D-galactosylceramide

2 entries

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

24 entries

UDPglucose + 2-(2-hydroxyacyl)sphingosine

glucocerebroside + UDP

Gallus gallus

-

at 7-10% of the activity with UDP-galactose

489215

-

489215

?

additional information

?

-

13 entries

UDP-galactose + ceramide

UDP + D-galactosylceramide

Rattus norvegicus

-

-

489240

-

489240

?

UDP-galactose + ceramide

UDP + D-galactosylceramide

Rattus norvegicus

-

erythro-ceramides, unsaturated ceramides and bound sphingosines are more active than threo-ceramides, saturated and free sphingosines

489240

-

489240

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Gallus gallus

-

-

489221

-

489221

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Gallus gallus

-

highly specific

489215

product: galactocerebroside containing 2-hydroxy fatty acids linked to the amino group of the sphingosine moiety

489215

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Gallus gallus

-

ceramide containing 2-hydroxystearic acid as the predominant fatty acid

489215

product: galactocerebroside containing 2-hydroxy fatty acids linked to the amino group of the sphingosine moiety

489215

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Gallus gallus

-

i.e. 2-hydroxy fatty acid ceramide, synthesis of cerebroside

489215

-

489215

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Gallus gallus

-

enzyme may play an important role in the synthesis of at least one type of myelin

489215

-

489215

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Homo sapiens

-

-

489220

-

489220

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Homo sapiens

-

-

489224

-

489224

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Homo sapiens

-

-

489222

galactoceramide

489222

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Homo sapiens

-

i.e. 2-hydroxy fatty acid ceramide

489221

i.e. 2-hydroxy fatty acid galactosylceramide

489221

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Homo sapiens

-

key enzymatic step in the biosynthesis of the galactocerebrosides, cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocytes of CNS and in Schwann cells of PNS

489222

galactocerebroside

489222

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Homo sapiens

-

key enzyme in the biosynthesis of galactocerebroside, the most abundant glycosphingolipid in the myelin sheath

489224

galactocerebroside

489224

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Mus musculus

-

-

489220

-

489220

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Mus musculus

-

highly specific

489214

2-hydroxy fatty acid cerebroside, i.e. 2-hydroxy fatty acid galactosylceramide

489214

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Mus musculus

-

i.e. 2-hydroxy fatty acid ceramide

489214

2-hydroxy fatty acid cerebroside, i.e. 2-hydroxy fatty acid galactosylceramide

489214

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Mus musculus

-

i.e. 2-hydroxy fatty acid ceramide, synthesis of cerebroside

489214

-

489214

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Rattus norvegicus

-

-

489217

-

489217

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Rattus norvegicus

-

-

489218

-

489218

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Rattus norvegicus

-

-

489220

-

489220

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Rattus norvegicus

-

-

489225

cerebroside

489225

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Rattus norvegicus

-

-

489215

i.e. 2-hydroxy fatty acid galactosylceramide

489215

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Rattus norvegicus

-

i.e. 2-hydroxy fatty acid ceramide

489216

cerebroside

489216

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Rattus norvegicus

-

i.e. 2-hydroxy fatty acid ceramide

489223

cerebroside

489223

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Rattus norvegicus

-

i.e. 2-hydroxy fatty acid ceramide

489216

2-hydroxy fatty acid cerebroside, i.e. 2-hydroxy fatty acid galactosylceramide

489216

?

UDPgalactose + 2-(2-hydroxyacyl)sphingosine

1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP

Rattus norvegicus Wistar

-

-

489225

cerebroside

489225

?

additional information

?

-

Gallus gallus

-

not: galactose, galactose-1-phosphat, ADP-galactose

489215

-

-

?

additional information

?

-

Homo sapiens

-

-

489220

-

-

?

additional information

?

-

Homo sapiens

-

final step of galactosylceramide synthesis, which plays a role in myelin formation, signal transduction and oligodendrocyte development

489221

-

-

?

additional information

?

-

Mus musculus

-

not: ceramide containing nonhydroxy fatty acids

489214

-

-

?

additional information

?

-

Mus musculus

-

key enzyme in the biosynthesis of cerebrosides and sulfatides, cell-specific and highly time-regulated expression of the CGT gene is thought to play an important role in oligodendrocyte and Schwann cell differentiation

489220

-

-

?

additional information

?

-

Rattus norvegicus

-

-

489215

-

-

?

additional information

?

-

Rattus norvegicus

-

-

489220

-

-

?

additional information

?

-

Rattus norvegicus

-

not: glucosylceramide, lactosylceramide, asialo GM2ganglioside

489216

-

-

?

additional information

?

-

Rattus norvegicus

-

not: ceramide containing nonhydroxy fatty acids

489216

-

-

?

additional information

?

-

Rattus norvegicus

-

oligodendrocyte-specific enzyme is involved in the biosynthesis of the oligodendrocyte- and myelin-specific cerebrosides, time-regulated CGT expression with a peak around postnatal days 15-25

489225

-

-

?

additional information

?

-

Rattus norvegicus

-

last step in biosynthesis of cerebrosides

489223

-

-

?

additional information

?

-

Rattus norvegicus

-

enzyme ensures a supply of UDP-galactose in the endoplasmic reticulum lumen by retaining UDP-galactose transporter in a molecular complex

662811

-

-

?

additional information

?

-

Rattus norvegicus Wistar

-

oligodendrocyte-specific enzyme is involved in the biosynthesis of the oligodendrocyte- and myelin-specific cerebrosides, time-regulated CGT expression with a peak around postnatal days 15-25

489225

-

-

?