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2.4.1.47: N-acylsphingosine galactosyltransferase

This is an abbreviated version!
For detailed information about N-acylsphingosine galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.47

Reaction

UDP-alpha-D-galactose
+
a ceramide
=
UDP
 +
a beta-D-galactosylceramide

Synonyms

ceramide galactosyltransferase, cerebroside synthase, CGalT, CGT, EC 2.4.1.45, galactosyltransferase, uridine diphosphogalactose-2-hydroxyacylsphingosine, galactosyltransferase, uridine diphosphogalactose-acylsphingosine, GALT, UDP galactose-N-acylsphingosine galactosyltransferase, UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase, UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase, UDPgalactose:ceramide galactosyltransferase, UGT8, uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase, uridine diphosphogalactose-acylsphingosine galactosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.47 N-acylsphingosine galactosyltransferase

Disease

topprint

Disease on EC 2.4.1.47 - N-acylsphingosine galactosyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Ataxia
Disruption of axo-glial junctions causes cytoskeletal disorganization and degeneration of Purkinje neuron axons.
Breast Neoplasms
Association between CLN3 (Neuronal Ceroid Lipofuscinosis, CLN3 Type) Gene Expression and Clinical Characteristics of Breast Cancer Patients.
Ceramide galactosyltransferase (UGT8) is a molecular marker of breast cancer malignancy and lung metastases.
Inhibition of UGT8 suppresses basal-like breast cancer progression by attenuating sulfatide-?V?5 axis.
Demyelinating Diseases
Oligodendrocyte-specific ceramide galactosyltransferase (CGT) expression phenotypically rescues CGT-deficient mice and demonstrates that CGT activity does not limit brain galactosylceramide level.
Oligodendrocytes assist in the maintenance of sodium channel clusters independent of the myelin sheath.
Tellurium causes dose-dependent coordinate down-regulation of myelin gene expression.
Galactosemias
The molecular relationship between deficient UDP-galactose uridyl transferase (GALT) and ceramide galactosyltransferase (CGT) enzyme function: a possible cause for poor long-term prognosis in classic galactosemia.
Leukodystrophy, Globoid Cell
Substrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor.
Leukodystrophy, Metachromatic
Substrate reduction therapy for Krabbe disease and metachromatic leukodystrophy using a novel ceramide galactosyltransferase inhibitor.
Lung Neoplasms
Expression of Ceramide Galactosyltransferase (UGT8) in Primary and Metastatic Lung Tissues of Non-Small-Cell Lung Cancer.
Neoplasm Metastasis
Ceramide galactosyltransferase (UGT8) is a molecular marker of breast cancer malignancy and lung metastases.
Neoplasms
Ceramide galactosyltransferase (UGT8) as a molecular marker of canine mammary tumor malignancy.
Ceramide galactosyltransferase (UGT8) is a molecular marker of breast cancer malignancy and lung metastases.
Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer.
Oligodendroglioma
Biosynthesis of galactocerebrosides and glucocerebrosides in glial cell lines.