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Literature summary for 2.4.1.47 extracted from

  • Padmini, S.; Rao, P.S.
    UDP galactose:ceramide galactosyltransferase, CDP choline:1,2-diacyl-sn-glycerol phosphocholine transferase, and microsomal reductases in major regions of the developing rat brain in nutritional stress (1989), J. Neurosci. Res., 23, 310-315.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information nutritional inadequacy during the active growth phase of the brain causes significantly diminished enzyme activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus last step in biosynthesis of cerebrosides ?
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Wistar rats
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Rattus norvegicus
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7, 14 and 21 days old
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Source Tissue

Source Tissue Comment Organism Textmining
brain cerebrum, cerebellum and brain stem of 14 and 21 days old rats, whole brain of 7 days old rats Rattus norvegicus
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brain stem cerebrum, cerebellum and brain stem of 14 and 21 days old rats Rattus norvegicus
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cerebellum cerebrum, cerebellum and brain stem of 14 and 21 days old rats Rattus norvegicus
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cerebrum cerebrum, cerebellum and brain stem of 14 and 21 days old rats Rattus norvegicus
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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more, specific activity is maximal at about 21 days and then gradually declines Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information last step in biosynthesis of cerebrosides Rattus norvegicus ?
-
?
UDPgalactose + 2-(2-hydroxyacyl)sphingosine i.e. 2-hydroxy fatty acid ceramide Rattus norvegicus 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP cerebroside ?