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Literature summary for 2.4.1.47 extracted from

  • Bosio, A.; Binczek, E.; Le Beau, M.M.; Fernald, A.A.; Stoffel, W.
    The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): Cloning, characterization, and assignment to human chromosome 4, band q26 (1996), Genomics, 34, 69-75.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocyte of CNS and in Schwann cells of PNS Homo sapiens
cloning and characterization of the CGT gene, chromosomal localization as a single-copy gene to 4q26 Homo sapiens
nucleotide sequence of the cDNA, single-copy gene Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane integrated into ER membrane, enzymatically active part of CGT may be oriented toward the lumen of the ER Homo sapiens 5789
-
membrane with transmembrane helical domain, hydrophobic sequence of 20 amino acids in the C-terminal domain Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDPgalactose + 2-(2-hydroxyacyl)sphingosine Homo sapiens key enzymatic step in the biosynthesis of the galactocerebrosides, cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocytes of CNS and in Schwann cells of PNS 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP galactocerebroside ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDPgalactose + 2-(2-hydroxyacyl)sphingosine
-
Homo sapiens 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP galactoceramide ?
UDPgalactose + 2-(2-hydroxyacyl)sphingosine key enzymatic step in the biosynthesis of the galactocerebrosides, cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocytes of CNS and in Schwann cells of PNS Homo sapiens 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP galactocerebroside ?