Cloned (Comment) | Organism |
---|---|
cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocyte of CNS and in Schwann cells of PNS | Homo sapiens |
cloning and characterization of the CGT gene, chromosomal localization as a single-copy gene to 4q26 | Homo sapiens |
nucleotide sequence of the cDNA, single-copy gene | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | integrated into ER membrane, enzymatically active part of CGT may be oriented toward the lumen of the ER | Homo sapiens | 5789 | - |
membrane | with transmembrane helical domain, hydrophobic sequence of 20 amino acids in the C-terminal domain | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDPgalactose + 2-(2-hydroxyacyl)sphingosine | Homo sapiens | key enzymatic step in the biosynthesis of the galactocerebrosides, cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocytes of CNS and in Schwann cells of PNS | 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP | galactocerebroside | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDPgalactose + 2-(2-hydroxyacyl)sphingosine | - |
Homo sapiens | 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP | galactoceramide | ? | |
UDPgalactose + 2-(2-hydroxyacyl)sphingosine | key enzymatic step in the biosynthesis of the galactocerebrosides, cell-specific and highly time-regulated expression of the CGT gene in the terminal differentiated oligodendrocytes of CNS and in Schwann cells of PNS | Homo sapiens | 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine + UDP | galactocerebroside | ? |