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2.3.3.16: citrate synthase (unknown stereospecificity)

This is an abbreviated version!
For detailed information about citrate synthase (unknown stereospecificity), go to the full flat file.

Word Map on EC 2.3.3.16

Reaction

acetyl-CoA
+
H2O
+
oxaloacetate
=
citrate
+
CoA

Synonyms

bifunctional citrate synthase/2-methylcitrate synthase, CCNA_01983, CIT1, CitA, citrate condensing enzyme, citrate oxaloacetate-lyase (CoA-acetylating), citrate oxaloacetate-lyase, CoA-acetylating, citrate synthase, citrate synthase Cit1, citrate synthase/2-methylcitrate synthase, citrate synthetase, citric synthase, citric-condensing enzyme, citrogenase, CitZ, CS, CS1, CS2, CS3, CS4, CSI, CSY, CSY4, CTS, EC 4.1.3.7, gltA, GltA2, MCS, mitochondrial citrate synthase, mmgD, More, Msed_1522, oxalacetic transacetase, oxaloacetate transacetase, peroxisomal citrate synthase, Rv0896, SbnG, Si-citrate synthase, sll0401, SSO2589, St0589, St1805, synthase, citrate, TTHA1343, type II citrate synthase

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.3 Acyl groups converted into alkyl groups on transfer
                2.3.3.16 citrate synthase (unknown stereospecificity)

Activating Compound

Activating Compound on EC 2.3.3.16 - citrate synthase (unknown stereospecificity)

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ammonium sulfate
-
activates at 0.5 mM
CaCl2
100 mM, 151% increase in activity
Guanidinium chloride
-
activation of recombinant wild-type 1.6fold at 0.5 M, inactivation at 1.6 M
KCl
100 mM, 88% increase in activity. Activation is pH dependent
light
-
light activates up to 1.4fold, regulation in correlation with photosynthesis
-
MgCl2
100 mM, 291% increase in activity
NaCl
100 mM, 105% increase in activity
thioredoxin
a strong and more than 8fold activation of enzyme activity is observed for isoform CS4 with Escherichia coli thioredoxin coupled to reduction by NTR and NADPH