2.3.3.16: citrate synthase (unknown stereospecificity)
This is an abbreviated version!
For detailed information about citrate synthase (unknown stereospecificity), go to the full flat file.
Word Map on EC 2.3.3.16
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2.3.3.16
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4.1.3.7
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malate
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1.1.1.35
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glyoxysomal
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1.2.4.1
-
al-induced
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agriculture
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synthesis
- 2.3.3.16
-
4.1.3.7
- malate
-
1.1.1.35
- glyoxysomal
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1.2.4.1
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al-induced
- agriculture
- synthesis
Reaction
Synonyms
bifunctional citrate synthase/2-methylcitrate synthase, CCNA_01983, CIT1, CitA, citrate condensing enzyme, citrate oxaloacetate-lyase (CoA-acetylating), citrate oxaloacetate-lyase, CoA-acetylating, citrate synthase, citrate synthase Cit1, citrate synthase/2-methylcitrate synthase, citrate synthetase, citric synthase, citric-condensing enzyme, citrogenase, CitZ, CS, CS1, CS2, CS3, CS4, CSI, CSY, CSY4, CTS, EC 4.1.3.7, gltA, GltA2, MCS, mitochondrial citrate synthase, mmgD, More, Msed_1522, oxalacetic transacetase, oxaloacetate transacetase, peroxisomal citrate synthase, Rv0896, SbnG, Si-citrate synthase, sll0401, SSO2589, St0589, St1805, synthase, citrate, TTHA1343, type II citrate synthase
ECTree
2.3.3.16 citrate synthase (unknown stereospecificity)Advanced search results
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results (Substrates Products
Substrates Products on EC 2.3.3.16 - citrate synthase (unknown stereospecificity)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
propanoyl-CoA + H2O + oxaloacetate
(2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
bifunctional enzyme with 2.3-fold higher activity as a 2-methylcitrate synthase
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
MmgD is a bifunctional citrate synthase/2-methylcitrate synthase with 2.3fold higher activity as a 2-methylcitrate synthase. The enzyme is involved in the methylcitric acid cycle
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
MmgD is a bifunctional citrate synthase/2-methylcitrate synthase with 2.3fold higher activity as a 2-methylcitrate synthase
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
bifunctional enzyme with 2.3-fold higher activity as a 2-methylcitrate synthase
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
MmgD is a bifunctional citrate synthase/2-methylcitrate synthase with 2.3fold higher activity as a 2-methylcitrate synthase. The enzyme is involved in the methylcitric acid cycle
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
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-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
limited proteolysis of citrate synthase from Sulfolobus solfataricus by trypsin reduces the rate of the overall reaction (acetyl-CoA + oxaloacetate + H2O -> citrate + CoASH) to 4% but does not affect the hydrolysis of citryl-CoA. A connecting link between the enzyme's ligase and hydrolase activity becomes impaired specifically on treatment with trypsin. Other proteolytic enzymes like chymotrypsin and subtilisin inactivate catalytic functions of citrate synthase, ligase and hydrolase, equally well
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
the activity with propanoyl-CoA is not tested
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-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
-
limited proteolysis of citrate synthase from Sulfolobus solfataricus by trypsin reduces the rate of the overall reaction (acetyl-CoA + oxaloacetate + H2O -> citrate + CoASH) to 4% but does not affect the hydrolysis of citryl-CoA. A connecting link between the enzyme's ligase and hydrolase activity becomes impaired specifically on treatment with trypsin. Other proteolytic enzymes like chymotrypsin and subtilisin inactivate catalytic functions of citrate synthase, ligase and hydrolase, equally well
-
-
?
acetyl-CoA + H2O + oxaloacetate
citrate + CoA
the activity with propanoyl-CoA is not tested
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-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
entry step to tricarboxylic acid cycle
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-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
the enzyme is required for fatty acid respiration and seed germination, the enzyme is not only a key enzyme of the glyoxylate cycle but also catalyzes an essential step in the respiration of fatty acids
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-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
only anabolic pathway
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
contributes little to flux control in the pathway
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
Aspergillus niger N400 / DSM 2466 / ATCC 9029 / CBS 120.49
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
Aspergillus niger N400 / DSM 2466 / ATCC 9029 / CBS 120.49
contributes little to flux control in the pathway
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
entry step to tricarboxylic acid cycle
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
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high activity necessary for N2 fixation
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-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
entry step to tricarboxylic acid cycle
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
entry step to tricarboxylic acid cycle
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
entry step to tricarboxylic acid cycle
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
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key enzyme of glyoxylate cycle in fat-storing seedlings
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-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
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involved in poly 3-hydroxybutyrate synthesis
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-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
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key enzyme of tricarboxylic acid cycle
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-
r
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
Dictyostelium discoideum NC-4 / ATCC 24697
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key enzyme of tricarboxylic acid cycle
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-
r
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
entry step to tricarboxylic acid cycle
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
only anabolic pathway
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
only anabolic pathway
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
involved in poly 3-hydroxybutyrate synthesis
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
entry step to tricarboxylic acid cycle
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
the activity with propanoyl-CoA is not tested
-
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
the activity with propanoyl-CoA is not tested
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-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
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no channeling of oxaloacetate between malate dehydrogenase and citrate synthase in a recombinant fusion protein using a coupled assay
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ir
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
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regulation of mitochondrial uptake and efflux by citrate synthase activity
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-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
entry step to tricarboxylic acid cycle
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?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
entry step to tricarboxylic acid cycle
-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
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condensation step is reversible
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r
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
-
also acting as structural protein in oral morphogenesis and conjugation
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-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
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also acting as structural protein in oral morphogenesis and conjugation
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-
?
acetyl-CoA + oxaloacetate + H2O
citrate + CoA
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condensation step nearly irreversible, reversibility is increased at 70°C
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r
propionyl-CoA + H2O + oxaloacetate
(2S,3S)-2-methylcitrate + CoA
MmgD is a bifunctional citrate synthase/2-methylcitrate synthase with 2.3fold higher activity as a 2-methylcitrate synthase. The enzyme is involved in the methylcitric acid cycle
-
-
?
propionyl-CoA + H2O + oxaloacetate
(2S,3S)-2-methylcitrate + CoA
MmgD is a bifunctional citrate synthase/2-methylcitrate synthase with 2.3fold higher activity as a 2-methylcitrate synthase
-
-
?
propionyl-CoA + oxaloacetate + H2O
2-methylcitrate + CoA
methylcitrase synthase, also exhibiting citrate synthase activity
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?
propionyl-CoA + oxaloacetate + H2O
2-methylcitrate + CoA
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only the dimeric enzyme form, no activity with the hexameric enzyme form
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?
additional information
?
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differences in acid accumulation between acidless and acid-containing fruits may not be attributed to changes in the ativity of citrate synthase
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-
?
additional information
?
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differences in acid accumulation between acidless and acid-containing fruits may not be attributed to changes in the ativity of citrate synthase
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-
?
additional information
?
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differences in acid accumulation between acidless and acid-containing fruits may not be attributed to changes in the ativity of citrate synthase
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-
?
additional information
?
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mechanism for domain closure. It appears that there is a common barrier between the open- and closed-domain conformations that cannot be overcome in either exploring or targeting simulations. For citrate synthase in the open conformation there are 258 atoms from both domains that are in the domain-contact sets. This increases to only 284 for the closed structure. These atoms come from 61 residues in the open which increases to 66 in the closed. Of these, 57 are common to both open and closed conformations
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-
?
additional information
?
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the enzyme does not have any methylcitrate synthase activity
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-
?
additional information
?
-
the activity with propanoyl-CoA is not tested
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-
?
additional information
?
-
the activity with propanoyl-CoA is not tested
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-
?
additional information
?
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-
cells with cit1 deletion show higher tendency toward glutathione depletion and subsequent accumulation of reactive oxygen species than the wild type. GSH deficiency in cit1 null cells is caused by an insufficient supply of glutamate necessary for biosynthesis of GSH rather than the depletion of reducing power required for reduction of GSSG to GSH
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-
?
additional information
?
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yeast mutants lacking mitochondrial NAD+-specific isocitrate dehydrogenase or aconitase share several growth phenotypes as well as patterns of specific protein expression that differ from the parental strain. These shared properties of idhD and aco1D strains are eliminated or moderated by codisruption of the CIT1 gene encoding mitochondrial citrate synthase
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-
?
additional information
?
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no activity with propionyl-CoA
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-
?
additional information
?
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yeast mutants lacking mitochondrial NAD+-specific isocitrate dehydrogenase or aconitase share several growth phenotypes as well as patterns of specific protein expression that differ from the parental strain. These shared properties of idhD and aco1D strains are eliminated or moderated by codisruption of the CIT1 gene encoding mitochondrial citrate synthase
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-
?
additional information
?
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citrate synthase is essential for nodule maintenance in infection of alfalfa
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-
?
