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2.3.1.23: 1-acylglycerophosphocholine O-acyltransferase

This is an abbreviated version!
For detailed information about 1-acylglycerophosphocholine O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.23

Reaction

acyl-CoA
+
1-acyl-sn-glycero-3-phosphocholine
=
CoA
 +
1,2-diacyl-sn-glycero-3-phosphocholine

Synonyms

1-acyl-sn-glycero-3-phosphocholine acyltransferase, 1-acylglycerol-3-phosphate O-acyltransferase 8, 1-acylglycerophosphocholine acyltransferase, 1-AGP acyltransferase 8, 1-AGPAT 8, 1-AGPAT7, acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, acyl-CoA:glycerophosphocholine acyltransferase, acyl-CoA:lysocardiolipin acyltransferase 1, acyl-CoA:lysophosphatidylcholine acyltransferase, acyl-CoA:lysophosphatidylethanolamine acyltransferase 2, acyl-CoA:lysophospholipid acyltransferase, acyltransferase, lysolecithin, AGPAT7, AGPAT8, Alcat1, ALE1, At1g78690, AtLPLAT2, AYTL1, AYTL2, AYTL3, CF3, CG18445, CsLPCAT, GPCAT, hPrdx6, Lclat1, LPAT, LPC acyltransferase, LPCAT, LPCAT1, LPCAT2, LPCAT3, LPCAT4, LPEAT2, LPG acyltransferase, LPGAT, LPGAT1, LPLAT, LPLAT5, lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1, LYCAT, lyso-PAF acetyltransferase, lyso-PC acyltransferase, lyso-PC acyltransferase 1, lyso-phosphatidylcholine acyltransferase 1, lysolecithin acyltransferase, lysoPC acyltransferase, lysophosphatide acyltransferase, lysophosphatidylcholine acyl transferase, lysophosphatidylcholine acyltransferase, lysophosphatidylcholine acyltransferase 1, lysophosphatidylcholine acyltransferase 3, lysophosphatidylcholine acyltransferase 4, lysophosphatidylethanolamine acyltransferase 2, lysophosphocholine acyltransferase 1, lysophosphocholine acyltransferase 2, lysophosphocholine acyltransferase 3, lysophosphocholine acyltransferase 4, lysophospholipid acyltransferase, lysophospholipid:acyl-CoA acyltransferase, mboa-6, MBOAT protein Nes, MBOAT5, membrane-bound O-acyltransferase 5, mLPEAT2, More, mPrdx6, N-acylphosphatidylethanolamine synthase, NAPE synthase, PCAT1, PCAT2, PGAT, rPrdx6, YALI0E16797g, yeast tafazzin, Ypr140wp

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.23 1-acylglycerophosphocholine O-acyltransferase

Inhibitors

Inhibitors on EC 2.3.1.23 - 1-acylglycerophosphocholine O-acyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-acyl-sn-glycero-3-phosphocholine
1-alkenylglycerophosphocholine
-
-
1-azido-oleoyl-sn-lysophosphatidylcholine
-
0.2 mM, 50% inactivation after photolysis
1-decyl propanediol-3-phosphorylcholine
-
-
1-dodecyl propanediol-3-phosphorylcholine
-
-
1-hexadecyl propanediol-3-phosphorylcholine
-
-
1-octadecyl propanediol-3-phosphorylcholine
-
-
1-tetradecyl propanediol-3-phosphorylcholine
-
-
18-(4'-azido-2'-hydroxybenzoylamino)-oleic acid
-
0.4 mM; 73% inhibition, reversible inhibition in the dark, irreversible inactivation after photolysis, used as photoaffinity label
2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-dodecanamide
-
-
2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
-
-
2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone
-
potent inhibitor
2-[5-(thiophen-3-yl)pyridin-3-yl]ethanol
non-competitive
3,4-dihydroxy-1,2-dimethoxy-5-methylbenzene
-
-
3-acetoxy-2-methoxy-5-methyl-1,4-benzoquinone
-
-
3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone
-
potent inhibitor
3-hexanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone
-
-
acyl-CoA
-
-
ADP
-
-
Ag+
-
0.000005 mM, almost complete inhibition, noncompetitive, irreversible, probably due to formation of a thiolate
AMP
-
-
arachidonic acid
-
0.045 mM, 50% inhibition
Arachidonoyl-CoA
-
high concentration
Berol-043
-
0.25%, 90% inhibition
-
bovine serum albumin
-
3 mg/ml, 50% inhibition
-
Brij 35
-
0.1%
Brij 98
-
0.1%
cholate
-
1%, 90% inhibition
CI-976
Clofibric acid
-
inhibition of mitochondrial enzyme
Cu2+
-
0.00001 mM, 50% inhibition, noncompetitive, irreversible, probably due to formation of a thiolate
Cyclic nucleotide phosphodiesterase inhibitors
-
deoxycholate
-
0.25%, 90% inhibition
Dibucaine
-
-
dihydrofumigatin
-
i.e. 2-methoxy-1,3,4- trihydroxy-5-methylbenzene
dipalmitoylphosphatidylcholine
-
-
DTNB
complete inhibition of LPCAT in wild-type and in recombinant heterologous yeast microsomes
ethanol
-
integral membrane enzyme, 10%, 20% inhibition
fumigatin
-
i.e. 3-hydroxy-2-methoxy-5-methyl-1,4-benzoquinone
glycocholate
-
0.2%, 90% inhibition
Hg2+
-
0.00001 mM, 50% inhibition, noncompetitive, irreversible, probably due to formation of a thiolate
iodoacetate
lipopolysaccharide
suppresses the enzyme activity of isozyme LPCAT3 toward linoleoyl-CoA and arachidonoyl-CoA in phorbol 12-myristate 13-acetate-treated U-937 cells
Lubrol WX
-
0.1%
-
lysolecithin
-
-
lysolecithin analogs
-
above 0.1 mM, C10-C16, competitive inhibition
methanol
-
oleoyl-CoA as substrate
Methyllidocaine
-
inhibition of heart enzyme
N-ethylmaleimide
Nonidet P-40
-
0.25%, 90% inhibition
o-phenanthroline
-
2 mM, 82% inhibition, 1 mM, 73% inhibition
oleic acid
-
0.08 mM, 50% inhibition
p-chloromercuribenzoate
-
partially restorable by dithiothreitol
p-chloromercuriphenyl sulfonic acid
palmitic acid
-
0.15 mM, 50% inhibition
palmitoyl-CoA
palmitoyltrifluoromethylketone
-
0.15 mM, 50% inhibition
Pb2+
-
0.00002 mM, 50% inhibition, noncompetitive, irreversible, probably due to formation of a thiolate
Phosphorylhomocholine
photooxidized phospholipids
-
0.0001-0.01 mM photoxoidized phospholipids preincubated with 0.1 mg microsomal membranes, approx. 45% loss of initial activity
-
procaine
-
-
Pronase
-
T0901317
a liver X recpeotr agonist
Tetracaine
-
-
thimerosal
-
Triton X-100
Trypsin
-
TSI-10
an LPCAT3 inhibitor
Tween 20
-
0.1%
Tween 80
-
0.1%
WY-14643
-
inhibition of mitochondrial enzyme
Zn2+
-
0.1 mM, 67% inhibition, 1 mM, 93% inhibition
additional information
-