2.3.1.23: 1-acylglycerophosphocholine O-acyltransferase

This is an abbreviated version!
For detailed information about 1-acylglycerophosphocholine O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.23

2.3.1.23

acyl-coas

lysophospholipids

phospholipase

arachidonic

polyunsaturated

lysophosphatidic

reacylation

lncrnas

platelet-activating

glycerophospholipids

palmitoyl-coa

oleoyl-coa

arachidonoyl-coa

lysopcs

cholinephosphotransferase

kennedy

lysophospholipase

deacylation-reacylation

lysophosphatidylinositol

mboats

oleoyl

lecithin-cholesterol

transacylation

arachidonoyl

linoleoyl-coa

acyl-coa-dependent

lysophosphatidylserine

thimerosal

disaturated

glycerolphosphate

coa-independent

cholinephosphate

lysophosphatidylglycerol

pharmacology

medicine

Reaction

Synonyms

1-acyl-sn-glycero-3-phosphocholine acyltransferase, 1-acylglycerol-3-phosphate O-acyltransferase 8, 1-acylglycerophosphocholine acyltransferase, 1-AGP acyltransferase 8, 1-AGPAT 8, 1-AGPAT7, acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, acyl-CoA:glycerophosphocholine acyltransferase, acyl-CoA:lysocardiolipin acyltransferase 1, acyl-CoA:lysophosphatidylcholine acyltransferase, acyl-CoA:lysophosphatidylethanolamine acyltransferase 2, acyl-CoA:lysophospholipid acyltransferase, acyltransferase, lysolecithin, AGPAT7, AGPAT8, Alcat1, ALE1, At1g78690, AtLPLAT2, AYTL1, AYTL2, AYTL3, CF3, CG18445, CsLPCAT, GPCAT, hPrdx6, Lclat1, LPAT, LPC acyltransferase, LPCAT, LPCAT1, LPCAT2, LPCAT3, LPCAT4, LPEAT2, LPG acyltransferase, LPGAT, LPGAT1, LPLAT, LPLAT5, lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1, LYCAT, lyso-PAF acetyltransferase, lyso-PC acyltransferase, lyso-PC acyltransferase 1, lyso-phosphatidylcholine acyltransferase 1, lysolecithin acyltransferase, lysoPC acyltransferase, lysophosphatide acyltransferase, lysophosphatidylcholine acyl transferase, lysophosphatidylcholine acyltransferase, lysophosphatidylcholine acyltransferase 1, lysophosphatidylcholine acyltransferase 3, lysophosphatidylcholine acyltransferase 4, lysophosphatidylethanolamine acyltransferase 2, lysophosphocholine acyltransferase 1, lysophosphocholine acyltransferase 2, lysophosphocholine acyltransferase 3, lysophosphocholine acyltransferase 4, lysophospholipid acyltransferase, lysophospholipid:acyl-CoA acyltransferase, mboa-6, MBOAT protein Nes, MBOAT5, membrane-bound O-acyltransferase 5, mLPEAT2, More, mPrdx6, N-acylphosphatidylethanolamine synthase, NAPE synthase, PCAT1, PCAT2, PGAT, rPrdx6, YALI0E16797g, yeast tafazzin, Ypr140wp

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.23 1-acylglycerophosphocholine O-acyltransferase

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Results	in table
25	Activating Compound
741	AA Sequence
2	Application
1	CAS Registry Number
38	Cloned(Commentary)
533	Disease/ Diagnostics
7	Expression
54	General Information
2	General Stability
9	IC50 Value
110	Inhibitors
8	kcat/KM [mM/s]
6	Ki Value [mM]
65	KM Value [mM]
105	Localization
2	Metals/Ions
16	Molecular Weight [Da]
66	Natural Substrates/ Products (Substrates)
194	Organism
14	Pathway
39	pH Optimum
7	pH Range
3	Posttranslational Modification
32	Protein Variants
27	Purification (Commentary)
3	Reaction
1	Reaction Type
125	Reference
247	Source Tissue
52	Specific Activity [micromol/min/mg]
8	Storage Stability
328	Substrates and Products (Substrate)
20	Subunits
216	Synonyms
1	Systematic Name
44	Temperature Optimum [°C]
2	Temperature Range [°C]
9	Temperature Stability [°C]
2	Turnover Number [1/s]

Localization

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Localization on EC 2.3.1.23 - 1-acylglycerophosphocholine O-acyltransferase

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cytoplasm

4 entries

cytosol

Oryctolagus cuniculus

5829

486622

endoplasmic reticulum

6 entries

endoplasmic reticulum membrane

in addition to endoplasmic reticulum, both isoforms LCAT1 and LCAT2 localize to lipid droplets, which consist of a core of neutral lipids surrounded by a monolayer of phospholipid, mainly phosphatidylcholine. This dual localization is enabled by the monotopic topology of the enzymes with both termini facing the cytoplasm, irrespective of supplementation with oleic acid. Lipid droplets have the ability to locally synthesize phosphatidylcholine and this activity correlates with the LPCAT1 and -2 expression levels

Oryctolagus cuniculus

membrane

plastid membrane

additional information

5 entries