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1-palmitoyl-2-lysophosphatidylcholine + arachidonoyl-CoA
1-palmitoyl-2-arachidonoylphosphatidylcholine + CoA
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?
1-palmitoyl-2-lysophosphatidylcholine + linoleoyl-CoA
1-palmitoyl-2-linoleoylphosphatidylcholine + CoA
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?
1-palmitoyl-2-lysophosphatidylcholine + oleoyl-CoA
1-palmitoyl-2-oleoylphosphatidylcholine + CoA
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?
1-palmitoyl-2-lysophosphatidylcholine + palmitoyl-CoA
1,2-dipalmitoylphosphatidylcholine + CoA
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?
acyl-CoA + 1-acyl-lysophosphatidylcholine
CoA + 1,2-diacyl-lysophosphatidylcholine
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acyl-CoA + 1-acyl-lysophosphatidylethanolamine
CoA + 1,2-diacyl-lysophosphatidylethanolamine
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?
acyl-CoA + 1-acyl-lysophosphatidylglycerol
CoA + 1,2-diacyl-lysophosphatidylglycerol
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?
acyl-CoA + 1-acyl-lysophosphatidylinositol
CoA + 1,2-diacyl-lysophosphatidylinositol
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acyl-CoA + 1-acyl-lysophosphatidylserine
CoA + 1,2-diacyl-lysophosphatidylserine
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?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
acyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1,2-diacyl-sn-glycero-3-phosphoethanolamine
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?
acyl-CoA + 1-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
acyl-CoA + 2-acyl-sn-lysophosphatidylglycerol
CoA + 1,2-diacyl-sn-lysophosphatidylglycerol
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?
alpha-linolenoyl-CoA + 1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-alpha-linolenoyl-lysophosphatidylcholine
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r
alpha-linolenoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-alpha-linolenoyl-sn-glycero-3-phosphocholine
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r
arachidonoyl-CoA + 1-acyl-lysophosphatidylcholine
CoA + 1-acyl-2-arachidonoyl-lysophosphatidylcholine
preferred substrate
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?
arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
docosahexaenoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-docosahexaenoyl-sn-glycero-3-phosphoethanolamine
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?
linoleoyl-CoA + 1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-linoleoyl-lysophosphatidylcholine
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r
linoleoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1-oleoyl-2-linoleoyl-sn-glycero-3-phosphocholine
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r
oleoyl-CoA + 1-acyl-sn-glycero-3-phosphoethanolamine
CoA + 1-acyl-2-oleoyl-sn-glycero-3-phosphoethanolamine
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?
oleoyl-CoA + 1-oleoyl-lysophosphatidic acid
CoA + 1,2-dioleoyl-sn-lysophosphatidic acid
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r
oleoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dioleoyl-lysophosphatidylcholine
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r
oleoyl-CoA + 1-oleoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dioleoyl-sn-glycero-3-phosphocholine
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r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
palmitoyl-CoA + 1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-palmitoyl-lysophosphatidylcholine
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low activity
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r
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
palmitoyl-CoA + 1-palmitoyl-sn-lysophosphatidylcholine
CoA + 1,2-dipalmitoyl-sn-lysophosphatidylcholine
dipalmitoyl-PC is biosynthesized by LPCAT1 in the Lands' cycle
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stearoyl-CoA + 1-oleoyl-lysophosphatidylcholine
CoA + 1-oleoyl-2-stearoyl-lysophosphatidylcholine
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low activity
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r
additional information
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acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
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participates in deacylation/reacylation cycle of cell membranes
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?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
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determines composition of phosphocholine in myocardium
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?
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
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acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
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acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
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phosphatidylcholine is the major site for polyunsaturated fatty acid synthesis
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r
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
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acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
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acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
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acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
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participates in deacylation/reacylation cycle of cell membranes
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?
acyl-CoA + 1-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
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acyl-CoA + 1-acyl-sn-lysophosphatidylcholine
CoA + 1,2-diacyl-sn-lysophosphatidylcholine
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arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
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arachidonoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
CoA + 1-acyl-2-arachidonoyl-sn-glycero-3-phosphocholine
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oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
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r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
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r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
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r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
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r
palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
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palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
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palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
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palmitoyl-CoA + 1-palmitoyl-sn-glycero-3-phosphocholine
CoA + 1,2-dipalmitoyl-sn-glycero-3-phosphocholine
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additional information
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the specificity of the enzyme may respresent a barrier to the incorporation of medium-chain fatty acids at the sn-2 position of triacylglycerol
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additional information
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with the different seed microsomal fractions, substrate specificity, overview. Gondoyl-CoA and erucoyl-CoA, which are not accepted by CsLPCATs. The most preferred acyl donor in the assays with the microsomal fraction of the 24 and 31 days-after-flowering (DAF) seeds is linoleoyl-CoA, at 17 DAF alpha-linolenoyl-CoA is preferred. The activity of the backward reactions of the CsLPCATs in seed microsomal fractions is generally the highest at 17 DAF. Low activity with sn-2-O-glycero-3-phosphocholines (cf. EC 2.3.1.62)
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additional information
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priming of Mono-Mac 6 cells by IFNgamma appears to involve LPCAT
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additional information
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the enzyme may mediate the priming reactions of monocytes to the cytokine interferon-gamma. The enzyme might also effect the responses of monocytes to the bacterial agent lipopolysaccharide that may be important in the development of sepsis
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additional information
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inhibition of Golgi complex-associated LPAT activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticulum, affecting secretory and endocytic membrane trafficking pathways, overview
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additional information
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a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicates that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
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additional information
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the enzyme is involved in dipalmitoylphosphatidylcholine synthesis
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additional information
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the enzyme is involved in dipalmitoylphosphatidylcholine synthesis
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additional information
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the enzyme synthesizes phosphatidylcholine in pulmonary surfactant and plays a pivotal role in respiratory physiology and in membrane biogenesis
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additional information
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the enzyme synthesizes phosphatidylcholine in pulmonary surfactant and plays a pivotal role in respiratory physiology and in membrane biogenesis
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additional information
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histone H4 protein is subject to palmitoylation catalyzed by Lpcat1 in a calcium-regulated manner. Cytosolic Lpcat1 shifts into the nucleus in lung epithelia in response to exogenous Ca2+. Nuclear Lpcat1 colocalizes with and binds to histone H4, where it catalyzes histone H4 palmitoylation. Residue Ser47 within histone H4 serves as a putative acceptor site, indicative of Lpcat1-mediated O-palmitoylation. Lpcat1 knock-down or expression of a histone H4 Ser47A mutant protein in cells decreases cellular mRNA synthesis
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additional information
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enzyme LPCAT1 directly interacts with StarD10 protein, amino acids 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction. The enzyme also interacts with StarD7-I but not StarD7-II or StarD2/PCTP transfer protein
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additional information
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a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
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additional information
?
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a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
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additional information
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LPCAT3 is critical for introduction of polyunsaturated fatty acids (PUFAs), especially arachidonic acid (20:4) at the sn-2 position of various LPLs, generating various types of arachidonoyl phospholipids
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additional information
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LPCAT3 is critical for introduction of polyunsaturated fatty acids (PUFAs), especially arachidonic acid (20:4) at the sn-2 position of various LPLs, generating various types of arachidonoyl phospholipids
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additional information
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LPCAT3 is critical for introduction of polyunsaturated fatty acids (PUFAs), especially arachidonic acid (20:4) at the sn-2 position of various LPLs, generating various types of arachidonoyl phospholipids
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additional information
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LPCAT4 has lysophosphatidylethanolamine acyltransferase as well as LPCAT activity. LPCAT uses lysophosphatidylcholine (LPC) as a substrate to generate phosphatidylcholine. Preference of LPCAT4 for oleoyl-CoA during chondrogenic differentiation. LPCAT4 does not prefer linoleoyl-, (5Z,8Z,11Z,14Z)-eicosatetraenoyl-, or docosahexaenoyl-CoA. Analysis of the fatty acid composition of whole cell lysates
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additional information
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LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
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additional information
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LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
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additional information
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LYCAT introduces stearic acid (18:0) selectively at the sn-1 position of lysophosphatidylinositol (LPI). The enzyme also catalyzes the reacylation of lysocardiolipin to cardiolipin
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additional information
?
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a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicated that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
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additional information
?
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enzyme LPCAT1 directly interacts with StarD10 protein, amino acids 79-271 of LPCAT1 and the steroidogenic acute regulatory protein-related lipid transfer (START) domain of START domain-containing protein 10 (StarD10) are sufficient for this interaction. The enzyme also interacts with StarD7-I but not StarD7-II or StarD2/PCTP transfer protein
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additional information
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Golgi membrane tubule formation can result from increasing the content of lysophospholipids in membranes, either by stimulation of a phospholipase A2 or by inhibition of an lysophosphatidylcholine acyltransferase. The two opposing enzyme activities may help to coordinately regulate Golgi membrane shape and tubule formation
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additional information
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inhibition of Golgi complex-associated LPAT activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticulum, affecting secretory and endocytic membrane trafficking pathways, overview
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?
additional information
?
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the enzyme is involved in dipalmitoylphosphatidylcholine synthesis
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?
additional information
?
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a linear incorporation of labeled fatty acyl CoA into dipalmitoyl phosphatidylcholine (PC) indicates that lysophosphatidylcholine generated by Prdx6 PLA2 activity remains bound to the enzyme for the reacylation reaction
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