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2.3.1.23: 1-acylglycerophosphocholine O-acyltransferase

This is an abbreviated version!
For detailed information about 1-acylglycerophosphocholine O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.23

Reaction

acyl-CoA
+
1-acyl-sn-glycero-3-phosphocholine
=
CoA
 +
1,2-diacyl-sn-glycero-3-phosphocholine

Synonyms

1-acyl-sn-glycero-3-phosphocholine acyltransferase, 1-acylglycerol-3-phosphate O-acyltransferase 8, 1-acylglycerophosphocholine acyltransferase, 1-AGP acyltransferase 8, 1-AGPAT 8, 1-AGPAT7, acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, acyl-CoA:glycerophosphocholine acyltransferase, acyl-CoA:lysocardiolipin acyltransferase 1, acyl-CoA:lysophosphatidylcholine acyltransferase, acyl-CoA:lysophosphatidylethanolamine acyltransferase 2, acyl-CoA:lysophospholipid acyltransferase, acyltransferase, lysolecithin, AGPAT7, AGPAT8, Alcat1, ALE1, At1g78690, AtLPLAT2, AYTL1, AYTL2, AYTL3, CF3, CG18445, CsLPCAT, GPCAT, hPrdx6, Lclat1, LPAT, LPC acyltransferase, LPCAT, LPCAT1, LPCAT2, LPCAT3, LPCAT4, LPEAT2, LPG acyltransferase, LPGAT, LPGAT1, LPLAT, LPLAT5, lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1, LYCAT, lyso-PAF acetyltransferase, lyso-PC acyltransferase, lyso-PC acyltransferase 1, lyso-phosphatidylcholine acyltransferase 1, lysolecithin acyltransferase, lysoPC acyltransferase, lysophosphatide acyltransferase, lysophosphatidylcholine acyl transferase, lysophosphatidylcholine acyltransferase, lysophosphatidylcholine acyltransferase 1, lysophosphatidylcholine acyltransferase 3, lysophosphatidylcholine acyltransferase 4, lysophosphatidylethanolamine acyltransferase 2, lysophosphocholine acyltransferase 1, lysophosphocholine acyltransferase 2, lysophosphocholine acyltransferase 3, lysophosphocholine acyltransferase 4, lysophospholipid acyltransferase, lysophospholipid:acyl-CoA acyltransferase, mboa-6, MBOAT protein Nes, MBOAT5, membrane-bound O-acyltransferase 5, mLPEAT2, More, mPrdx6, N-acylphosphatidylethanolamine synthase, NAPE synthase, PCAT1, PCAT2, PGAT, rPrdx6, YALI0E16797g, yeast tafazzin, Ypr140wp

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.23 1-acylglycerophosphocholine O-acyltransferase

Expression

Expression on EC 2.3.1.23 - 1-acylglycerophosphocholine O-acyltransferase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme LPCAT3 is upregulated by liver X receptor LXR agonists, e.g. T0901317, in human macrophages
hepatic LPCAT3 gene is transcriptionally regulated by peroxisome proliferator-activated receptor delta (PPARdelta). Activation of PPARdelta by agonist L165041 in mice increases hepatic LPCAT3 mRNA abundance and LPCAT enzymatic activity, which is associated with increased incorporations of arachidonate into liver phosphatidylcholine and phosphatidylethanolamine. Liver X receptor (LXR) is the important transcription factor controlling LPCAT3 expression in liver tissue via an LXR response element (LXRE) in the proximal promoter region of the murine Lpcat3 gene. The ligand-induced activation of LXR reduces hepatic inflammation and emdoplasmic reticulum stress in hyperlipidemic mice through a LPCAT3-mediated mechanism
hepatic LPCAT3 gene is transcriptionally regulated by peroxisome proliferator-activated receptor delta (PPARdelta). Adenovirus-mediated knockdown of PPARdelta in cultured hepatic cells and liver tissue reduced LPCAT3 mRNA levels, and exogenous overexpression of PPARdelta increases LPCAT3 mRNA expression. Activation of PPARdelta in Hep-G2, Huh-7, and Hepa 1-6 cells with its specific agonists increases LPCAT3 mRNA levels in all three hepatic cell lines. The functional PPAR-responsive element to a proximal region from -135 to -123 of the LPCAT3 promoter plays an essential role in mediating PPARdelta-induced transactivation of the LPCAT3 gene. Upregulation of human LPCAT3 promoter activity in HepG2 cells by PPARdelta agonists, e.g. L165041 and GW0742, and LXR agonist, e.g. GW3965. Specific interaction of PPARdelta with PPRE1 motif of LPCAT3 promoter is enhanced by ligand treatment
lipopolysaccharide significantly downregulates the mRNA expression of isozyme LPCAT3
LPCAT2 expression is increased by 16 h treatment with lipopolysaccharides
LPCAT4 mRNA expression increases during chondrogenic differentiation
upregulated in colorectal adenocarcinomas (compared to normal mucosas)