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2.3.1.23: 1-acylglycerophosphocholine O-acyltransferase

This is an abbreviated version!
For detailed information about 1-acylglycerophosphocholine O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.23

Reaction

acyl-CoA
+
1-acyl-sn-glycero-3-phosphocholine
=
CoA
+
1,2-diacyl-sn-glycero-3-phosphocholine

Synonyms

1-acyl-sn-glycero-3-phosphocholine acyltransferase, 1-acylglycerol-3-phosphate O-acyltransferase 8, 1-acylglycerophosphocholine acyltransferase, 1-AGP acyltransferase 8, 1-AGPAT 8, 1-AGPAT7, acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, acyl-CoA:glycerophosphocholine acyltransferase, acyl-CoA:lysocardiolipin acyltransferase 1, acyl-CoA:lysophosphatidylcholine acyltransferase, acyl-CoA:lysophosphatidylethanolamine acyltransferase 2, acyl-CoA:lysophospholipid acyltransferase, acyltransferase, lysolecithin, AGPAT7, AGPAT8, Alcat1, ALE1, At1g78690, AtLPLAT2, AYTL1, AYTL2, AYTL3, CF3, CG18445, CsLPCAT, GPCAT, hPrdx6, Lclat1, LPAT, LPC acyltransferase, LPCAT, LPCAT1, LPCAT2, LPCAT3, LPCAT4, LPEAT2, LPG acyltransferase, LPGAT, LPGAT1, LPLAT, LPLAT5, lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1, LYCAT, lyso-PAF acetyltransferase, lyso-PC acyltransferase, lyso-PC acyltransferase 1, lyso-phosphatidylcholine acyltransferase 1, lysolecithin acyltransferase, lysoPC acyltransferase, lysophosphatide acyltransferase, lysophosphatidylcholine acyl transferase, lysophosphatidylcholine acyltransferase, lysophosphatidylcholine acyltransferase 1, lysophosphatidylcholine acyltransferase 3, lysophosphatidylcholine acyltransferase 4, lysophosphatidylethanolamine acyltransferase 2, lysophosphocholine acyltransferase 1, lysophosphocholine acyltransferase 2, lysophosphocholine acyltransferase 3, lysophosphocholine acyltransferase 4, lysophospholipid acyltransferase, lysophospholipid:acyl-CoA acyltransferase, mboa-6, MBOAT protein Nes, MBOAT5, membrane-bound O-acyltransferase 5, mLPEAT2, More, mPrdx6, N-acylphosphatidylethanolamine synthase, NAPE synthase, PCAT1, PCAT2, PGAT, rPrdx6, YALI0E16797g, yeast tafazzin, Ypr140wp

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.23 1-acylglycerophosphocholine O-acyltransferase

Cloned

Cloned on EC 2.3.1.23 - 1-acylglycerophosphocholine O-acyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in COS-7 cell and SW-480 cell
expressed in Escherichia coli
expressed in Saccharomyces cerevisiae
expressed in Sf9 insect cell
expressed in yeast
expression in A-431 cell and COS-7 cell
expression in A-431 cell, COS-7 cell, and Hu-H7 cell
expression in COS-7 cells and in Sf9 insect cells
-
expression in Escherichia coli
-
FLAG-tagged version expressed in CHO-K1 cell
FLAG-tagged version expressed in COS-7 cell
-
FLAG-tagged version expressed in HEK293T cell, expressed in Escherichia coli BL21 (DE3)
FLAG-tegged version expressed in CHO-K1 cell, expressed in HeLa cell
gene Agpat7, quantitative RT-PCR expression analysis, recombinant overexpression of FLAG-tagged mLPEAT2 in CHO cells
gene At1g78690, recombinant expression of His-tagged enzyme in Escherichia coli strain BLR(DE3)pLysS
gene AtLPCAT2, recombinant overexpression in Saccharomyces cerevisiae haploid ALE1-knockout strain (BY4742, Matalpa, his3DELTA1, leu2DELTA0, lys2DELTA0, ura3DELTA0, YOR175c::kanMX4)
gene LCLAT1, recombinant expression in HEK-293 cells
gene LPCAT1, functional recombinant expression in HEK-293 cells
gene LPCAT1, recombinant expression of FLAG- and HA-tagged full-length and truncated enzyme in HEK-293 cell microsomes, recombinant coexpression of His-tagged or GST-tagged enzyme with His-tagged StarD10 protein in Escherichia coli
gene LPCAT3, hepatic lysophosphatidylcholine acyltransferase 3 is encoded by a target gene regulated by peroxisome proliferator-activated receptor delta
gene LPCAT3, quantitative real-time RT-PCR enzyme expression analysis
gene LPCAT3, real-time PCR enzyme expression analysis
gene LPCAT3, recombinant expression in HEK-293 cells
gene LPCAT3, recombinant expression of C-terminally Twin-Strep-tagged enzyme in Spodoptera frugiperda Sf9 cells
gene prdx6, functional recombinant enzyme expression in mouse pulmonary microvascular endothelial cells via infection with a lentiviral vector construct
gene prdx6, recombinant enzyme expression
His-tagged version expressed in Saccharomyces cerevisiae
-
LPCAT, DNA and amino acid sequence determination and analysis, functional expression in COS-7 cells and HEK-293 cells
LPCAT1, DNA and amino acid sequence determination and analysis
LPCAT1, DNA and amino acid sequence determination and analysis, quantitative expression analysis, expression of FLAG-tagged enzyme in CHO-K1 cells, subcellular distribution pattern analysis shows enzyme expression mainly in the endoplasmic reticulum-Golgi, but also in mitochondria, and lysosome of the transfected cells
LPCAT1, quantitative real-time PCR expression analysis
two genes LPCAT, LPCAT1 and LPCAT2, containing eight exons and seven introns, respectively, DNA and amino acid seqquence determination and analysis, co-expression of flax genes LPCAT1 and diacylglycerol acyltransferase DGAT1-1 in the yeast quintuple mutant strain H1246 DELTAale1 significantly increasing 18-carbon polyunsaturated fatty acids in triacylglycerol with a concomitant decrease of 18-carbon polyunsaturated fatty acids in phospholipid. The specific activity of flax LPCAT1-catalyzed forward reaction is about 1000 times higher than that of flax DGAT1-catalyzed reaction when the expressed recombinant enzymes are assessed in yeast microsomes under in vitro enzyme assays
-