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2.3.1.23: 1-acylglycerophosphocholine O-acyltransferase

This is an abbreviated version!
For detailed information about 1-acylglycerophosphocholine O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.23

Reaction

acyl-CoA
+
1-acyl-sn-glycero-3-phosphocholine
=
CoA
 +
1,2-diacyl-sn-glycero-3-phosphocholine

Synonyms

1-acyl-sn-glycero-3-phosphocholine acyltransferase, 1-acylglycerol-3-phosphate O-acyltransferase 8, 1-acylglycerophosphocholine acyltransferase, 1-AGP acyltransferase 8, 1-AGPAT 8, 1-AGPAT7, acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase, acyl coenzyme A-monoacylphosphatidylcholine acyltransferase, acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase, acyl-CoA:glycerophosphocholine acyltransferase, acyl-CoA:lysocardiolipin acyltransferase 1, acyl-CoA:lysophosphatidylcholine acyltransferase, acyl-CoA:lysophosphatidylethanolamine acyltransferase 2, acyl-CoA:lysophospholipid acyltransferase, acyltransferase, lysolecithin, AGPAT7, AGPAT8, Alcat1, ALE1, At1g78690, AtLPLAT2, AYTL1, AYTL2, AYTL3, CF3, CG18445, CsLPCAT, GPCAT, hPrdx6, Lclat1, LPAT, LPC acyltransferase, LPCAT, LPCAT1, LPCAT2, LPCAT3, LPCAT4, LPEAT2, LPG acyltransferase, LPGAT, LPGAT1, LPLAT, LPLAT5, lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1, LYCAT, lyso-PAF acetyltransferase, lyso-PC acyltransferase, lyso-PC acyltransferase 1, lyso-phosphatidylcholine acyltransferase 1, lysolecithin acyltransferase, lysoPC acyltransferase, lysophosphatide acyltransferase, lysophosphatidylcholine acyl transferase, lysophosphatidylcholine acyltransferase, lysophosphatidylcholine acyltransferase 1, lysophosphatidylcholine acyltransferase 3, lysophosphatidylcholine acyltransferase 4, lysophosphatidylethanolamine acyltransferase 2, lysophosphocholine acyltransferase 1, lysophosphocholine acyltransferase 2, lysophosphocholine acyltransferase 3, lysophosphocholine acyltransferase 4, lysophospholipid acyltransferase, lysophospholipid:acyl-CoA acyltransferase, mboa-6, MBOAT protein Nes, MBOAT5, membrane-bound O-acyltransferase 5, mLPEAT2, More, mPrdx6, N-acylphosphatidylethanolamine synthase, NAPE synthase, PCAT1, PCAT2, PGAT, rPrdx6, YALI0E16797g, yeast tafazzin, Ypr140wp

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.23 1-acylglycerophosphocholine O-acyltransferase

Specific Activity

Specific Activity on EC 2.3.1.23 - 1-acylglycerophosphocholine O-acyltransferase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0001
-
activity in freshly prepared erythrocyte membranes with palmitoyl-CoA as acyl donor
0.0004
purified unphosphorylated recombinant mutant D31A enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.0006
-
activity in stored erythrocyte membranes with palmitoyl-CoA as acyl donor
0.0007
-
activity in freshly prepared erythrocyte membranes with oleoyl-CoA as acyl donor
0.0008
-
activity in stored erythrocyte membranes with oleoyl-CoA as acyl donor
0.002
-
at 5°C
0.0028
-
crude extract, TLC assay
0.0029
-
crude extract, silic acid microcolumn assay
0.0038
-
at 20°C
0.006
substrate: stearoyl-CoA, 37°C, cooperativity: Hill number 3.7
0.01
-
partially purified enzyme, 1-palmitoyl-glycero-3-phosphocholine as substrate
0.013
-
acyl donor oleoyl-CoA, heart enzyme
0.024
purified unphosphorylated recombinant enzyme, pH 7.0, 30°C, substrates LPC and palmitoyl CoA
0.028
0.042
-
integral membrane enzyme, 1-palmitoyl-glycero-3-phosphocholine as substrate
0.05
substrate: stearoyl-CoA, 28°C, cooperativity: Hill number 2.7
0.058
-
acyl donor oleoyl-CoA, liver enzyme
0.059
purified unphosphorylated recombinant mutant C47S enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.06
-
1-azido-oleoyl-sn-lysophosphatidyl-N-methyl as substrate
0.064
purified unphosphorylated recombinant mutant S32A enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.065
0.066
purified unphosphorylated recombinant mutant D140A enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.068
purified unphosphorylated recombinant enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.079
-
acyl donor oleoyl-CoA
0.082
substrate: arachidonoyl-CoA, 37°C, cooperativity: Hill number 2.0
0.087
substrate: oleoyl-CoA, 37°C, cooperativity: Hill number 1.6
0.134
-
acyl donor linoleoyl-CoA
0.268
substrate: alpha-linolenoyl-CoA, 28°C, no cooperativity: Hill number 1.0
0.323
substrate: stearoyl-CoA, 37°C, cooperativity: Hill number 1.4
0.486
substrate: lysophosphatidylcholine, cooperativity: Hill number 1.7
0.529
substrate: arachidonoyl-CoA, 28°C, cooperativity: Hill number 2.0
0.61
-
acyl donor arachidonoyl-CoA
0.652
purified phosphorylated recombinant enzyme, pH 4.0, 30°C, substrates LPC and palmitoyl CoA
0.661
purified phosphorylated recombinant enzyme, pH 7.0, 30°C, substrates LPC and palmitoyl CoA
0.662
0.68
-
acyl donor arachidonoyl-CoA
0.759
substrate: oleoyl-CoA, 28°C, cooperativity: Hill number 2.0
13.33
-
acyl donor oleoyl-CoA
2.3
-
acyl donor arachidonoyl-CoA
4.125
-
1-acylglycerophosphoinositol O-acyltransferase
additional information