2.3.1.15: glycerol-3-phosphate 1-O-acyltransferase
This is an abbreviated version!
For detailed information about glycerol-3-phosphate 1-O-acyltransferase, go to the full flat file.
Word Map on EC 2.3.1.15
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2.3.1.15
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gpats
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triacylglycerols
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phospholipid
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phosphatidic
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glycerolipids
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acyl-coas
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triglyceride
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diacylglycerol
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adipose
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lysophosphatidic
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peroxisome
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lipogenesis
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lipogenic
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adipocytes
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palmitate
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sterol
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phosphatidylcholine
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palmitoyl-coa
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phosphohydrolase
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glycerophospholipids
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carnitine
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steatosis
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esterification
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stearoyl-coa
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dihydroxyacetone
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1-acylglycerol-3-phosphate
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cutin
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srebp-1
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phosphatidylglycerol
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palmitoyltransferase
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oleoyl-coa
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acyl-acyl
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cytidylyltransferase
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squash
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desaturase-1
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monoacylglycerol
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protein-1c
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acaca
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suberin
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synthesis
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nutrition
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cholinephosphotransferase
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insig1
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lipins
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medicine
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energy production
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biotechnology
- 2.3.1.15
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gpats
- triacylglycerols
- phospholipid
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phosphatidic
- glycerolipids
- acyl-coas
- triglyceride
- diacylglycerol
- adipose
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lysophosphatidic
- peroxisome
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lipogenesis
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lipogenic
- adipocytes
- palmitate
- sterol
- phosphatidylcholine
- palmitoyl-coa
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phosphohydrolase
- glycerophospholipids
- carnitine
- steatosis
- esterification
- stearoyl-coa
- dihydroxyacetone
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1-acylglycerol-3-phosphate
- cutin
- srebp-1
- phosphatidylglycerol
- palmitoyltransferase
- oleoyl-coa
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acyl-acyl
- cytidylyltransferase
- squash
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desaturase-1
- monoacylglycerol
- protein-1c
- acaca
- suberin
- synthesis
- nutrition
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cholinephosphotransferase
-
insig1
-
lipins
- medicine
- energy production
- biotechnology
Reaction
Synonyms
1-acyl-sn-glycerol-3-phosphate acyltransferase, 3-glycerophosphate acyltransferase, ACP:sn-glycerol-3-phosphate acyltransferase, acyl-CoA:glycerol-3-phosphate acyltransferase 1, acyl-CoA:sn-glycerol-3-phosphate O-acyltransferase, acyl-[acyl carrier protein]:sn-1-glycerol-3-phosphate acyltransferase, acyltransferase, glycerol phosphate, Ad-GPAT1, AGPAT, AGPAT10, AGPAT6, AGPAT8, AGPAT9, alpha-glycerophosphate acyltransferase, AT1G02390, AT1G06520, AT3G11430, AT4G00400, AT4G01950, AT5G06090, AT5G60620, AtGPAT1, AtGPAT2, AtGPAT3, AtGPAT5, AtGPAT7, AtGPAT8, AtGPAT9, cancer-testicular antigen, chloroplast glycerol-3-phosphate acyltransferase, CrGAPTcl, ER-associated GPAT, G3P acyltransferase, GAT, Gat1, GAT1p, GAT2p, glycerol 3-phosphate acyltransferase, glycerol phosphate acyltransferase, glycerol phosphate transacylase, glycerol-3-P acyltransferase 1, glycerol-3-phosphate acyltransferase, glycerol-3-phosphate acyltransferase 1, glycerol-3-phosphate acyltransferase 2, glycerol-3-phosphate acyltransferase 3, glycerol-3-phosphate acyltransferase 4, glycerol-3-phosphate acyltransferase 9, glycerol-3-phosphate acyltransferase-1, glycerol-3-phosphate acyltransferase-like protein 1, glycerol-3-phosphate O-acyltransferase, glycerol-3-phosphate-1 acyltransferase, glycerol-sn-3-phosphate acyltransferase 1, glycerophosphate acyltransferase, glycerophosphate transacylase, GPAM, GPAT, GPAT-1, GPAT-4, GPAT-9, GPAT1, GPAT2, GPAT3, GPAT3/AGPAT10, GPAT4, GPAT5, GPAT6, GPAT7, GPAT8, GPAT9, gpt1, Gpt2, LeGPAT, LiGPAT, LPAAT-theta, LPAAT-zeta, mGPAT, microsomal GPAT3, microsomal GPAT3/AGPAT10, microsomal GPAT4, mitochondrial glycerol-3-phosphate acyltransferase, mitochondrial GPAT1, mitochondrial GPAT2, More, MS33, mtGPAT, mtGPAT1, mtGPAT2, OsGPAT3, PHATRDRAFT_42446, PHYPADRAFT_137573, PLAT2, PlsB, PlsB1, Ppa GPAT9, PpGPAT9, PtGPAT, Rv1551, Rv1551 acyltransferase, SA1, Sn-glycerol 3-phosphate acyltransferase, sn-glycerol-3-phosphate acyltransferase, SsGPAT, TbGAT, water-soluble plastidial glycerol-3-phosphate acyltransferase, xGPAT1, xGPAT1-v1, xGPAT1-v2
ECTree
2.3.1.15 glycerol-3-phosphate 1-O-acyltransferaseAdvanced search results
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Source Tissue on EC 2.3.1.15 - glycerol-3-phosphate 1-O-acyltransferase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
epididymal fat, increased activity upon cessation of wheel running. Increase in mtGPAT protein might contribute to the overshoot in triacylglycerol synthesis
GPAT3 colocalize with the PAT (perilipin) family protein TIP47 (PLIN3) to the apical surface of the enterocyte
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in hepatopancreas mitochondria, a GPAT activity with characteristics similar to those of mammalian GPAT1 is identified
GPAT4 is expressed in around spermatids but not elongated spermatids during later spermiogenesis
additional information
Gpat3 mRNA increases 60fold during differentiation of 3T3-L1 preadipocytes to mature adipocytes, suggesting a critical role in adipocytes
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GPAT3 mRNA is dramatically upregulated during adipocyte differentiation
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GPAT3 mRNA is dramatically upregulated during adipocyte differentiation
the expression of GPAT2 is downregulated when 3T3-L1 cells differentiate into adipocytes, while GPAT1, 3, and 4 are upregulated (10fold, over 60, and 5fold, respectively)
the expression of GPAT2 is downregulated when 3T3-L1 cells differentiate into adipocytes, while GPAT1, 3, and 4 are upregulated 10fold, over 60fold, and 5fold, respectively
highest expression in white adipose tissue, moderate in brown adipose tissue
brown and white, high expression level
OsGPAT3 is preferentially expressed in the tapetum and microspores of the anther. In anther tissues, the expression of OsGPAT3 is detectable as early as stage 7, peaks at stage 8a, declined gradually until stage 10, then increases and peaks again at a lower level at stage 12, and thereafter declines, dynamic expression pattern of OsGPAT3
the enzyme is preferentially expressed in tapetal cells during anther development. Strong MS33 expression is detected in the tapetum from pre-meiosis to the binucleate stage
the enzyme is preferentially expressed in tapetal cells during anther development. Strong MS33 expression is detected in the tapetum from pre-meiosis to the binucleate stage. Strong MS33 expression is detected in the tapetum from pre-meiosis to the binucleate stage
isozyme GPAT2 is highly expressed in several cancer types (such as lung, melanoma, breast, and prostate cancer) and cancer-derived human cell lines
epididymal fat, increased activity upon cessation of wheel running. Increase in mtGPAT protein might contribute to the overshoot in triacylglycerol synthesis
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real-time PCR reveals that the mRNA accumulation of GPAT in Sueda salsa is induced by salt stress. The highest expression levels are observed when leaves are exposed to 300 mM NaCl treatment
GPAT4 accounts for the primary microsomal GPAT activity in liver
hypothesis: increased hepatic mtGPAT activity associated with obesity and insulin resistance contributes to increased triacylglycerol biosynthesis and inhibition of fatty acid oxidation, responses that would promote hepatic steatosis and dyslipidemia
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mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs
GPAT4 accounts for the primary microsomal GPAT activity in liver
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hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance
during lactation, GPAT4 mRNA is highly expressed in mammary gland epithelium, but not in the surrounding adipocytes of breast tissue
during lactation, GPAT4 mRNA is highly expressed in mammary gland epithelium, but not in the surrounding adipocytes of breast tissue
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during lactation, GPAT4 mRNA is highly expressed in mammary gland epithelium, but not in the surrounding adipocytes of breast tissue
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high expression level, GPAT3 expression analysis throughout the small intestine reveals that GPAT3 is abundantly expressed in the apical surface of enterocytes in the small intestine
aging reduces glycerol-3-phosphate acyltransferase activity in activated rat splenic T-lymphocytes
GPAT2 is mainly expressed in pachytene spermatocytes of testis
expression detected by RT-PCR: GPAT4 is strongly expressed in testis. First expression is detected in mice at 2 weeks postnatally. Expression is abundant from the third week, plateaus at week 5-6 and then maintains at a high level in the adult
GPAT2 expression in mouse testis fluctuates during sexual maturation, Gpat2 expression in mouse testis is maximal at the pachytene stage
GPAT2 is mainly expressed in pachytene spermatocytes of testis
GPAT4 is widely expressed postnatally in spermatocytes and around spermatids in mice testis
expression only in primary spermatocytes. During rat sexual maturation, both the testicular TAG content and the arachidonic acid content in the triacylglycerol fraction peak at 30 days, matching the highest expression of Gpat2 mRNA and protein
additional information
GPAT9 is constitutively expressed. The expression pattern is relatively broad. Comparable levels of GPAT9 expression are noted in the majority of tissues tested, including seedlings, rosette and cauline leaves (28 DAP), stems, roots, floral buds, open flowers, pollen, and siliques/seeds/embryos at various developmental stages. The highest levels of expression appears to be evident in leaves and developing siliques [at about 9 d after flowering (DAF)]
additional information
quantitative expression analysis of GPAT1 compared to other GPAT isozymes, overview
additional information
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quantitative expression analysis of GPAT1 compared to other GPAT isozymes, overview
additional information
quantitative expression analysis of GPAT1 compared to other GPAT isozymes, overview
additional information
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quantitative expression analysis of GPAT1 compared to other GPAT isozymes, overview
additional information
human GPAT3 is abundantly expressed in the kidney, heart, skeletal muscle, and thyroid gland. Tissue distribution, overview
additional information
human GPAT3 is abundantly expressed in the kidney, heart, skeletal muscle, and thyroid gland. Tissue distribution, overview
additional information
human GPAT3 is abundantly expressed in the kidney, heart, skeletal muscle, and thyroid gland. Tissue distribution, overview
additional information
mitochondrial GPAT1 activity is responsible for 30-50% of the total GPAT activity in the liver and approximately 30% of the total activity in the heart. GPAT1 is regulated at the transcriptional and posttranscriptional levels, and is highly expressed in adipose tissues and liver cells. Tissue distribution, overview
additional information
mitochondrial GPAT1 activity is responsible for 30-50% of the total GPAT activity in the liver and approximately 30% of the total activity in the heart. GPAT1 is regulated at the transcriptional and posttranscriptional levels, and is highly expressed in adipose tissues and liver cells. Tissue distribution, overview
additional information
mitochondrial GPAT1 activity is responsible for 30-50% of the total GPAT activity in the liver and approximately 30% of the total activity in the heart. GPAT1 is regulated at the transcriptional and posttranscriptional levels, and is highly expressed in adipose tissues and liver cells. Tissue distribution, overview
additional information
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high enzyme activity during the exponential growth phase of the parasite, but low during stationary phase
additional information
GPAT2 mRNA expression is increased and the content of triacylglycerol is significantly elevated in testis during sexual maturation in mice. Tissue distribution, overview
additional information
GPAT2 mRNA expression is increased and the content of triacylglycerol is significantly elevated in testis during sexual maturation in mice. Tissue distribution, overview
additional information
GPAT2 mRNA expression is increased and the content of triacylglycerol is significantly elevated in testis during sexual maturation in mice. Tissue distribution, overview
additional information
GPAT2 mRNA expression is increased and the content of triacylglycerol is significantly elevated in testis during sexual maturation in mice. Tissue distribution, overview
additional information
GPAT3 is predominantly expressed in the small intestine and adipose tissue, tissue distribution and expression pattern, overview
additional information
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GPAT3 is predominantly expressed in the small intestine and adipose tissue, tissue distribution and expression pattern, overview
additional information
the GPAT2 isoform expression is restricted to male germ cells and cancer cells
additional information
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the GPAT2 isoform expression is restricted to male germ cells and cancer cells
additional information
quantitative expression analysis of GPAT1 compared to other GPAT isozymes, overview
additional information
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quantitative expression analysis of GPAT1 compared to other GPAT isozymes, overview
additional information
the F2 mapping population is generated from a cross between osgpat3 (japonica) and GuangLuAi 4 (wild-type, indica) for gene mapping. Male sterile plants in the F2 population are chosen for gene mapping. Quantitative reverse-transcription real-time PCR assay and in situ hybridization
additional information
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the F2 mapping population is generated from a cross between osgpat3 (japonica) and GuangLuAi 4 (wild-type, indica) for gene mapping. Male sterile plants in the F2 population are chosen for gene mapping. Quantitative reverse-transcription real-time PCR assay and in situ hybridization
additional information
the highest expression of PpGPAT9 is detected in the mature sporophyte (SM), followed by the spores. The PpGPAT9 transcript levels are approximately 3fold and 1.6fold higher in 4-week-old and 8-week-old gametophores than in the protonema
additional information
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the highest expression of PpGPAT9 is detected in the mature sporophyte (SM), followed by the spores. The PpGPAT9 transcript levels are approximately 3fold and 1.6fold higher in 4-week-old and 8-week-old gametophores than in the protonema
additional information
quantitative PCR enzyme expression analysis, MS33 expression is dramatically stimulated in developing anthers, reaching a peak at the tetrad stage
additional information
quantitative PCR enzyme expression analysis, MS33 expression is dramatically stimulated in developing anthers, reaching a peak at the tetrad stage
