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2.3.1.15: glycerol-3-phosphate 1-O-acyltransferase

This is an abbreviated version!
For detailed information about glycerol-3-phosphate 1-O-acyltransferase, go to the full flat file.

Word Map on EC 2.3.1.15

Reaction

an acyl-CoA
+
sn-glycerol 3-phosphate
=
CoA
 +
a 1-acyl-sn-glycerol 3-phosphate

Synonyms

1-acyl-sn-glycerol-3-phosphate acyltransferase, 3-glycerophosphate acyltransferase, ACP:sn-glycerol-3-phosphate acyltransferase, acyl-CoA:glycerol-3-phosphate acyltransferase 1, acyl-CoA:sn-glycerol-3-phosphate O-acyltransferase, acyl-[acyl carrier protein]:sn-1-glycerol-3-phosphate acyltransferase, acyltransferase, glycerol phosphate, Ad-GPAT1, AGPAT, AGPAT10, AGPAT6, AGPAT8, AGPAT9, alpha-glycerophosphate acyltransferase, AT1G02390, AT1G06520, AT3G11430, AT4G00400, AT4G01950, AT5G06090, AT5G60620, AtGPAT1, AtGPAT2, AtGPAT3, AtGPAT5, AtGPAT7, AtGPAT8, AtGPAT9, cancer-testicular antigen, chloroplast glycerol-3-phosphate acyltransferase, CrGAPTcl, ER-associated GPAT, G3P acyltransferase, GAT, Gat1, GAT1p, GAT2p, glycerol 3-phosphate acyltransferase, glycerol phosphate acyltransferase, glycerol phosphate transacylase, glycerol-3-P acyltransferase 1, glycerol-3-phosphate acyltransferase, glycerol-3-phosphate acyltransferase 1, glycerol-3-phosphate acyltransferase 2, glycerol-3-phosphate acyltransferase 3, glycerol-3-phosphate acyltransferase 4, glycerol-3-phosphate acyltransferase 9, glycerol-3-phosphate acyltransferase-1, glycerol-3-phosphate acyltransferase-like protein 1, glycerol-3-phosphate O-acyltransferase, glycerol-3-phosphate-1 acyltransferase, glycerol-sn-3-phosphate acyltransferase 1, glycerophosphate acyltransferase, glycerophosphate transacylase, GPAM, GPAT, GPAT-1, GPAT-4, GPAT-9, GPAT1, GPAT2, GPAT3, GPAT3/AGPAT10, GPAT4, GPAT5, GPAT6, GPAT7, GPAT8, GPAT9, gpt1, Gpt2, LeGPAT, LiGPAT, LPAAT-theta, LPAAT-zeta, mGPAT, microsomal GPAT3, microsomal GPAT3/AGPAT10, microsomal GPAT4, mitochondrial glycerol-3-phosphate acyltransferase, mitochondrial GPAT1, mitochondrial GPAT2, More, MS33, mtGPAT, mtGPAT1, mtGPAT2, OsGPAT3, PHATRDRAFT_42446, PHYPADRAFT_137573, PLAT2, PlsB, PlsB1, Ppa GPAT9, PpGPAT9, PtGPAT, Rv1551, Rv1551 acyltransferase, SA1, Sn-glycerol 3-phosphate acyltransferase, sn-glycerol-3-phosphate acyltransferase, SsGPAT, TbGAT, water-soluble plastidial glycerol-3-phosphate acyltransferase, xGPAT1, xGPAT1-v1, xGPAT1-v2

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.15 glycerol-3-phosphate 1-O-acyltransferase

Activating Compound

Activating Compound on EC 2.3.1.15 - glycerol-3-phosphate 1-O-acyltransferase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(3-Morpholino)propanesulfonic acid-NaOH
-
i.e. MOPS-NaOH, activation, up to 30 mM
acetone
asolectin
-
i.e. crude mixture of soybean phospholipids, activation of mitochondrial enzyme
-
ATP
-
activation of acyltransferase in isolated membrane preparations
bovine serum albumin
-
cardiolipin
-
activation of reconstituted mitochondrial enzyme
dioleoyl phosphatidic acid
-
very strong activation
dioleoyl phosphatidylserine
-
best phospholipid for activation
dithiothreitol
-
1 mM, 82% activation
EDTA
-
10 mM, enhances activity, relative activity: 143%
Insulin
-
Gpat1 is upregulated by insulin
-
KF
-
stimulation of activity in microsomal preparation
Lubrol Px
-
above the critical micellar concentration
Non-site-specific proteases
-
activation, e.g. proteinase K, subtilisin, not chymotrypsin, trypsin, mitochondrial enzyme, degree of inhibition increases with decreasing ionic strength
-
oleate
presence of oleate induces dephosphorylation of isoform Gat1p as well as an increment in its levels. In presence of oleate, Gat1p crescent structures are formed which are connected with the endoplasmic reticulum and are intimately associated with lipid particles
phosphatidylcholine
phosphatidylethanolamine
phosphatidylglycerol
phosphatidylinositol
-
activation of mitochondrial enzyme
phosphatidylserine
-
activation of mitochondrial enzyme
Phospholipids
Polymyxin B
Proteases
-
activation, microsomal enzyme
-
rosiglitazone
GPAT3 activity increase in the white adipose tissue of diabetic mice after treatment with rosiglitazone, which is a PPAR-gamma agonist
spermidine
-
activates about 3.5fold in presence of 0.1 mg/ml bovine serum albumin
spermine
-
activates about 3fold in presence of 0.1 mg/ml bovine serum albumin
SREBP-1
-
Gpat1 is upregulated by SREBP-1
-
Triton X-100
-
i.e. octylphenoxy polyethoxyethanol, slight stimulation at 0.1 mg/ml
Zwittergent 3-14
-
above the critical micellar concentration
additional information
-
not activated by 1,2-diacyl glycerol 3-phosphate
-