1.21.99.3: thyroxine 5-deiodinase
This is an abbreviated version!
For detailed information about thyroxine 5-deiodinase, go to the full flat file.
Word Map on EC 1.21.99.3
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1.21.99.3
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thyroid
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triiodothyronine
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hypothyroidism
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tsh
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deiodination
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pituitary
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euthyroidism
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3,5,3'-triiodothyronine
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adipose
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5'-deiodination
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propylthiouracil
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l-thyroxine
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prohormone
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3,3',5'-triiodothyronine
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thyrotropin
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selenocysteine
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selenoproteins
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selenoenzyme
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iopanoic
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methimazole
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dlk1-dio3
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pituitary-thyroid
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3,3'-diiodothyronine
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medicine
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monodeiodination
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extrathyroidal
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se-deficient
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t3-dependent
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selenium-deficient
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hypothalamic-pituitary-thyroid
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amiodarone
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thyroidectomized
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harderian
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nonthyroidal
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thyroxine-binding
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thyrotropin-releasing
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thermogenic
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thyromimetically
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inner-ring
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6-n-propyl-2-thiouracil
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thyroid-stimulating
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thyrotoxicosis
- 1.21.99.3
- thyroid
- triiodothyronine
- hypothyroidism
- tsh
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deiodination
- pituitary
-
euthyroidism
- 3,5,3'-triiodothyronine
- adipose
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5'-deiodination
- propylthiouracil
- l-thyroxine
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prohormone
- 3,3',5'-triiodothyronine
- thyrotropin
- selenocysteine
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selenoproteins
-
selenoenzyme
-
iopanoic
- methimazole
-
dlk1-dio3
-
pituitary-thyroid
- 3,3'-diiodothyronine
- medicine
-
monodeiodination
-
extrathyroidal
-
se-deficient
-
t3-dependent
-
selenium-deficient
-
hypothalamic-pituitary-thyroid
- amiodarone
-
thyroidectomized
-
harderian
-
nonthyroidal
-
thyroxine-binding
-
thyrotropin-releasing
-
thermogenic
-
thyromimetically
-
inner-ring
- 6-n-propyl-2-thiouracil
-
thyroid-stimulating
-
thyrotoxicosis
Reaction
Synonyms
5'-deiodinase, D3, deiodinase, deiodinase 3, deiodinase, thyroxine 5-, deiodinase-3, diiodothyronine 5'-deiodinase, Dio, Dio3, Dio3a, Dio3b, EC 1.97.1.11, ID-3, iodothyronine 5-deiodinase, iodothyronine deiodinase type III, iodothyronine inner ring monodeiodinase, iodothyronine monodeiodinase, ITHD, T4-5'-deiodinase, T4-5-deiodinase, thyroxine 5-deiodinase, type 3 deiodinase, type 3 iodothyronine 5-deiodinase, type 3 iodothyronine deiodinase, type III deiodinase, type III iodothyronine deiodinase, type-3 deiodinase, zD3
ECTree
1.21.99.3 thyroxine 5-deiodinaseAdvanced search results
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results (Activating Compound
Activating Compound on EC 1.21.99.3 - thyroxine 5-deiodinase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
12-O-tetradecanoylphorbol-13-acetate
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induction of isozyme type III from brain astrocytes
basic fibroblast growth factor
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45fold induction of isozyme type III 5-deiodinase activity in vitro
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growth hormone
slightly upregulates the 5-deiodinase mRNA expression in the tail, but strongly downregulates it in the liver
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insulin-like growth factor I
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slight induction of isozyme type III 5-deiodinase activity in vitro
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Phospholipids
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no influence on the kinetic parameters of 5-deiodinase activity of isozyme type III in placenta, but essential for activity
platelet-derived growth factor
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slight induction of isozyme type III 5-deiodinase activity in vitro
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prolactin
upregulates the 5-deiodinase mRNA expression in the tail, but downregulates it in the liver
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Se2+
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required, depletion reversibly reduces the activity of isozyme type III by 3-10fold in cultured brain astrocytes
Vasopressin
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slight induction of isozyme type III 5-deiodinase activity in vitro
acidic fibroblast growth factor
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50fold induction of isozyme type III 5-deiodinase activity in vitro
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acidic fibroblast growth factor
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slight increase of 3,3',5,5'-tetraiodo-L-thyronine 5-deiodinase activity by isozyme type III
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acidic fibroblast growth factor
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induction of isozyme type III 3,3',5-triiodo-L-thyronine 5-deiodinase activity from brain astrocytes, 6fold higher in Se-repleted than in depleted cells
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Epidermal growth factor
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25fold induction of isozyme type III 5-deiodinase activity in vitro
additional information
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growth hormone increases plasma T3 and decreases plasma T4 levels in 8-day old chicken embryos, in newly hatched chicks and in adult chickens within 2 h after injection. Growth hormone has no effect at all on the amount of hepatic type I enzyme catalyzing T4 deiodination to T3 but acutely decreases the amount of type III enzyme catalyzing T3 deiodination
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additional information
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expression and function of 5-deiodinase are sensitive to thyroid hormone status, various cytokines and growth factors, severe illness, reactive oxygen species, a variety of hormones and signaling compounds, circadian rythm, and pharmacological agents
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additional information
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interaction with peroxiredoxin 3, rate-limiting role in regeneration of type 3 iodothyronine deiodinase
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additional information
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by activation of type 3 deiodinase during illness reduction of thyroid hormone levels
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