1.21.99.3: thyroxine 5-deiodinase

This is an abbreviated version!
For detailed information about thyroxine 5-deiodinase, go to the full flat file.

Word Map on EC 1.21.99.3

1.21.99.3

thyroid

triiodothyronine

hypothyroidism

tsh

deiodination

pituitary

euthyroidism

3,5,3'-triiodothyronine

adipose

5'-deiodination

propylthiouracil

l-thyroxine

prohormone

3,3',5'-triiodothyronine

thyrotropin

selenocysteine

selenoproteins

selenoenzyme

iopanoic

methimazole

dlk1-dio3

pituitary-thyroid

3,3'-diiodothyronine

medicine

monodeiodination

extrathyroidal

se-deficient

t3-dependent

selenium-deficient

hypothalamic-pituitary-thyroid

amiodarone

thyroidectomized

harderian

nonthyroidal

thyroxine-binding

thyrotropin-releasing

thermogenic

thyromimetically

inner-ring

6-n-propyl-2-thiouracil

thyroid-stimulating

thyrotoxicosis

Reaction

Synonyms

5'-deiodinase, D3, deiodinase, deiodinase 3, deiodinase, thyroxine 5-, deiodinase-3, diiodothyronine 5'-deiodinase, Dio, Dio3, Dio3a, Dio3b, EC 1.97.1.11, ID-3, iodothyronine 5-deiodinase, iodothyronine deiodinase type III, iodothyronine inner ring monodeiodinase, iodothyronine monodeiodinase, ITHD, T4-5'-deiodinase, T4-5-deiodinase, thyroxine 5-deiodinase, type 3 deiodinase, type 3 iodothyronine 5-deiodinase, type 3 iodothyronine deiodinase, type III deiodinase, type III iodothyronine deiodinase, type-3 deiodinase, zD3

ECTree

1 Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.99 With unknown physiological acceptors

1.21.99.3 thyroxine 5-deiodinase

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Results	in table
25	Activating Compound
18	AA Sequence
4	Application
1	CAS Registry Number
12	Cloned(Commentary)
35	Cofactor
2	Crystallization (Commentary)
290	Disease/ Diagnostics
10	Expression
18	General Information
19	IC50 Value
73	Inhibitors
6	Ki Value [mM]
40	KM Value [mM]
30	Localization
3	Metals/Ions
7	Molecular Weight [Da]
63	Natural Substrates/ Products (Substrates)
77	Organism
1	Pathway
21	pH Optimum
3	pI Value
2	Posttranslational Modification
16	Protein Variants
4	Purification (Commentary)
7	Reaction
3	Reaction Type
61	Reference
1	Renatured (Commentary)
156	Source Tissue
12	Specific Activity [micromol/min/mg]
182	Substrates and Products (Substrate)
10	Subunits
56	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
1	Temperature Stability [°C]

IC50 Value

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IC50 Value on EC 1.21.99.3 - thyroxine 5-deiodinase

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0.001

(2E)-2-(3,4-dihydroxybenzylidene)-4,6-dihydroxy-1-benzofuran-3(2H)-one

Rattus norvegicus

pH 7.4, 37°C

639397

0.0005

(2E)-4,6-dihydroxy-2-(4-hydroxy-3-iodobenzylidene)-1-benzofuran-3(2H)-one

Rattus norvegicus

pH 7.4, 37°C

639397

0.001

(2E)-4,6-dihydroxy-2-(4-hydroxybenzylidene)-1-benzofuran-3(2H)-one

Rattus norvegicus

pH 7.4, 37°C

639397

0.005

(4-[(E)-(4,6-dihydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)methyl]phenoxy)acetic acid

Rattus norvegicus

pH 7.4, 37°C

639397

0.0025

3',5'-diiodothyronine

Rattus norvegicus

pH 7.4, 37°C

639396

0.006

3,5,3'-triiodo-5'-nitrothyronine

Rattus norvegicus

pH 7.4, 37°C

639396

0.005

3,5,5'-triiodo-2'-methylthyronine

Rattus norvegicus

pH 7.4, 37°C

639396

0.01

3,5-diiodo-3',5'-dinitrothyronine

Rattus norvegicus

pH 7.4, 37°C

639396

0.014

3,5-diiodo-3'-hydroxythyronine

Rattus norvegicus

pH 7.4, 37°C

639396

0.017

3,5-diiodo-4'-amino-3',5'-dimethylthyronine

Rattus norvegicus

pH 7.4, 37°C

639396

0.43

aurothioglucose

Rattus norvegicus

pH 7.4, 37°C

639413

0.001

N-acetyl-3,5,3'-triiodo-5'-nitrothyronine

Rattus norvegicus

pH 7.4, 37°C

639396

0.006

N-acetyl-3,5-diiodo-3',5'-dinitrothyronine

Rattus norvegicus

pH 7.4, 37°C

639396

0.003

N-acetyl-3,5-diiodo-3'-bromo-5'-nitrothyronine

Rattus norvegicus

pH 7.4, 37°C

639396

0.002

Tetraiodothyroacetic acid

Rattus norvegicus

pH 7.4, 37°C

639396

0.0003

[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid

Rattus norvegicus

pH 7.4, 37°C

639396

0.001

[4-(4-hydroxy-3,5-dinitrophenoxy)-3,5-diiodophenyl]acetic acid

Rattus norvegicus

pH 7.4, 37°C

639396

0.0008

[4-(4-hydroxy-3-iodo-5-nitrophenoxy)-3,5-diiodophenyl]acetate

Rattus norvegicus

pH 7.4, 37°C

639396

0.001

[4-(4-hydroxy-3-iodo-5-nitrophenoxy)phenyl]acetic acid

Rattus norvegicus

pH 7.4, 37°C

639396