1.21.99.3: thyroxine 5-deiodinase
This is an abbreviated version!
For detailed information about thyroxine 5-deiodinase, go to the full flat file.
Word Map on EC 1.21.99.3
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1.21.99.3
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thyroid
-
triiodothyronine
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hypothyroidism
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tsh
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deiodination
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pituitary
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euthyroidism
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3,5,3'-triiodothyronine
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adipose
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5'-deiodination
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propylthiouracil
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l-thyroxine
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prohormone
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3,3',5'-triiodothyronine
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thyrotropin
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selenocysteine
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selenoproteins
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selenoenzyme
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iopanoic
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methimazole
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dlk1-dio3
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pituitary-thyroid
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3,3'-diiodothyronine
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medicine
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monodeiodination
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extrathyroidal
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se-deficient
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t3-dependent
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selenium-deficient
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hypothalamic-pituitary-thyroid
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amiodarone
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thyroidectomized
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harderian
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nonthyroidal
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thyroxine-binding
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thyrotropin-releasing
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thermogenic
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thyromimetically
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inner-ring
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6-n-propyl-2-thiouracil
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thyroid-stimulating
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thyrotoxicosis
- 1.21.99.3
- thyroid
- triiodothyronine
- hypothyroidism
- tsh
-
deiodination
- pituitary
-
euthyroidism
- 3,5,3'-triiodothyronine
- adipose
-
5'-deiodination
- propylthiouracil
- l-thyroxine
-
prohormone
- 3,3',5'-triiodothyronine
- thyrotropin
- selenocysteine
-
selenoproteins
-
selenoenzyme
-
iopanoic
- methimazole
-
dlk1-dio3
-
pituitary-thyroid
- 3,3'-diiodothyronine
- medicine
-
monodeiodination
-
extrathyroidal
-
se-deficient
-
t3-dependent
-
selenium-deficient
-
hypothalamic-pituitary-thyroid
- amiodarone
-
thyroidectomized
-
harderian
-
nonthyroidal
-
thyroxine-binding
-
thyrotropin-releasing
-
thermogenic
-
thyromimetically
-
inner-ring
- 6-n-propyl-2-thiouracil
-
thyroid-stimulating
-
thyrotoxicosis
Reaction
Synonyms
5'-deiodinase, D3, deiodinase, deiodinase 3, deiodinase, thyroxine 5-, deiodinase-3, diiodothyronine 5'-deiodinase, Dio, Dio3, Dio3a, Dio3b, EC 1.97.1.11, ID-3, iodothyronine 5-deiodinase, iodothyronine deiodinase type III, iodothyronine inner ring monodeiodinase, iodothyronine monodeiodinase, ITHD, T4-5'-deiodinase, T4-5-deiodinase, thyroxine 5-deiodinase, type 3 deiodinase, type 3 iodothyronine 5-deiodinase, type 3 iodothyronine deiodinase, type III deiodinase, type III iodothyronine deiodinase, type-3 deiodinase, zD3
ECTree
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Metals Ions
Metals Ions on EC 1.21.99.3 - thyroxine 5-deiodinase
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Se2+
the enzyme is a selenoenzyme encoded by the DIO3 gene. The DIO3 genomic structure contains a single exon and, at the 3'-UTR, a specific RNA structure, named SECIS (selenocysteine insertion element), that is crucial for the insertion of the selenocysteine residue and for maximal enzymatic catalytic efficiency. The DIO3 gene is imprinted, with preferential expression of the paternal allele. It belongs to a cluster of imprinted regions, at the DLK1-DIO3 locus