1.21.99.3: thyroxine 5-deiodinase
This is an abbreviated version!
For detailed information about thyroxine 5-deiodinase, go to the full flat file.
Word Map on EC 1.21.99.3
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1.21.99.3
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thyroid
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triiodothyronine
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hypothyroidism
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tsh
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deiodination
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pituitary
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euthyroidism
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3,5,3'-triiodothyronine
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adipose
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5'-deiodination
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propylthiouracil
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l-thyroxine
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prohormone
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3,3',5'-triiodothyronine
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thyrotropin
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selenocysteine
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selenoproteins
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selenoenzyme
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iopanoic
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methimazole
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dlk1-dio3
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pituitary-thyroid
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3,3'-diiodothyronine
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medicine
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monodeiodination
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extrathyroidal
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se-deficient
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t3-dependent
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selenium-deficient
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hypothalamic-pituitary-thyroid
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amiodarone
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thyroidectomized
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harderian
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nonthyroidal
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thyroxine-binding
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thyrotropin-releasing
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thermogenic
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thyromimetically
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inner-ring
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6-n-propyl-2-thiouracil
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thyroid-stimulating
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thyrotoxicosis
- 1.21.99.3
- thyroid
- triiodothyronine
- hypothyroidism
- tsh
-
deiodination
- pituitary
-
euthyroidism
- 3,5,3'-triiodothyronine
- adipose
-
5'-deiodination
- propylthiouracil
- l-thyroxine
-
prohormone
- 3,3',5'-triiodothyronine
- thyrotropin
- selenocysteine
-
selenoproteins
-
selenoenzyme
-
iopanoic
- methimazole
-
dlk1-dio3
-
pituitary-thyroid
- 3,3'-diiodothyronine
- medicine
-
monodeiodination
-
extrathyroidal
-
se-deficient
-
t3-dependent
-
selenium-deficient
-
hypothalamic-pituitary-thyroid
- amiodarone
-
thyroidectomized
-
harderian
-
nonthyroidal
-
thyroxine-binding
-
thyrotropin-releasing
-
thermogenic
-
thyromimetically
-
inner-ring
- 6-n-propyl-2-thiouracil
-
thyroid-stimulating
-
thyrotoxicosis
Reaction
Synonyms
5'-deiodinase, D3, deiodinase, deiodinase 3, deiodinase, thyroxine 5-, deiodinase-3, diiodothyronine 5'-deiodinase, Dio, Dio3, Dio3a, Dio3b, EC 1.97.1.11, ID-3, iodothyronine 5-deiodinase, iodothyronine deiodinase type III, iodothyronine inner ring monodeiodinase, iodothyronine monodeiodinase, ITHD, T4-5'-deiodinase, T4-5-deiodinase, thyroxine 5-deiodinase, type 3 deiodinase, type 3 iodothyronine 5-deiodinase, type 3 iodothyronine deiodinase, type III deiodinase, type III iodothyronine deiodinase, type-3 deiodinase, zD3
ECTree
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Source Tissue
Source Tissue on EC 1.21.99.3 - thyroxine 5-deiodinase
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additional information
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wild type, G2N2C and Tb3A transgenic BCC cell lines expressing Gli2 under the control of the keratin 5 promoter
expression is associated with the tubular epithelial cells and with the transitional epithelium, and the inner longotudinal and outer circular muscle layers of the ureter
maximum protein expression is shown in a thin layer of hepatocytes bordering the blood veins
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both isoforms Dio3a and Dio3b are expressed during development and both contribute to in vivo type 3 iodothyronine deiodinase activity
additional information
both isoforms Dio3a and Dio3b are expressed during development and both contribute to in vivo type 3 iodothyronine deiodinase activity
additional information
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not: kidney, healthy adult liver, pituitary gland, thyroid gland
additional information
the enzyme is prevalently expressed in many fetal tissues, through the adult it is expressed in placenta, brain, and skin, and to a lesser extent in the pregnant uterus and pancreatic B-cells. The enzyme activity increases rapidly during the proliferative phase of hemangioma
additional information
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5'-deiodinase and 5-deiodinase activity are developmentally regulated
additional information
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not: kidney, healthy adult liver, pituitary gland, thyroid gland
additional information
type 3 deiodinase activity, although normally expressed at very low levels in adult peripheral tissues, is increased to significant levels in the skin, kidney, and muscle of both fasted wild-type and type 1 and 2 deiodinase KO mice
additional information
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not: kidney, healthy adult liver, pituitary gland, thyroid gland