1.21.99.3: thyroxine 5-deiodinase
This is an abbreviated version!
For detailed information about thyroxine 5-deiodinase, go to the full flat file.
Word Map on EC 1.21.99.3
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1.21.99.3
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thyroid
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triiodothyronine
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hypothyroidism
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tsh
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deiodination
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pituitary
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euthyroidism
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3,5,3'-triiodothyronine
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adipose
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5'-deiodination
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propylthiouracil
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l-thyroxine
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prohormone
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3,3',5'-triiodothyronine
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thyrotropin
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selenocysteine
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selenoproteins
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selenoenzyme
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iopanoic
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methimazole
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dlk1-dio3
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pituitary-thyroid
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3,3'-diiodothyronine
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medicine
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monodeiodination
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extrathyroidal
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se-deficient
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t3-dependent
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selenium-deficient
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hypothalamic-pituitary-thyroid
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amiodarone
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thyroidectomized
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harderian
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nonthyroidal
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thyroxine-binding
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thyrotropin-releasing
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thermogenic
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thyromimetically
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inner-ring
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6-n-propyl-2-thiouracil
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thyroid-stimulating
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thyrotoxicosis
- 1.21.99.3
- thyroid
- triiodothyronine
- hypothyroidism
- tsh
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deiodination
- pituitary
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euthyroidism
- 3,5,3'-triiodothyronine
- adipose
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5'-deiodination
- propylthiouracil
- l-thyroxine
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prohormone
- 3,3',5'-triiodothyronine
- thyrotropin
- selenocysteine
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selenoproteins
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selenoenzyme
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iopanoic
- methimazole
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dlk1-dio3
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pituitary-thyroid
- 3,3'-diiodothyronine
- medicine
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monodeiodination
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extrathyroidal
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se-deficient
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t3-dependent
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selenium-deficient
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hypothalamic-pituitary-thyroid
- amiodarone
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thyroidectomized
-
harderian
-
nonthyroidal
-
thyroxine-binding
-
thyrotropin-releasing
-
thermogenic
-
thyromimetically
-
inner-ring
- 6-n-propyl-2-thiouracil
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thyroid-stimulating
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thyrotoxicosis
Reaction
Synonyms
5'-deiodinase, D3, deiodinase, deiodinase 3, deiodinase, thyroxine 5-, deiodinase-3, diiodothyronine 5'-deiodinase, Dio, Dio3, Dio3a, Dio3b, EC 1.97.1.11, ID-3, iodothyronine 5-deiodinase, iodothyronine deiodinase type III, iodothyronine inner ring monodeiodinase, iodothyronine monodeiodinase, ITHD, T4-5'-deiodinase, T4-5-deiodinase, thyroxine 5-deiodinase, type 3 deiodinase, type 3 iodothyronine 5-deiodinase, type 3 iodothyronine deiodinase, type III deiodinase, type III iodothyronine deiodinase, type-3 deiodinase, zD3
ECTree
1.21.99.3 thyroxine 5-deiodinaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 1.21.99.3 - thyroxine 5-deiodinase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(2E)-2-(3,4-dihydroxybenzylidene)-4,6-dihydroxy-1-benzofuran-3(2H)-one
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aurone derivative isolated from plant extract. Comparison with inhibition of 5'-deiodinase EC 1.97.1.10
(2E)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one
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aurone derivative isolated from plant extract. Comparison with inhibition of 5'-deiodinase EC 1.97.1.10
(2E)-4,6-dihydroxy-2-(4-hydroxy-3-iodobenzylidene)-1-benzofuran-3(2H)-one
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aurone derivative isolated from plant extract. Comparison with inhibition of 5'-deiodinase EC 1.97.1.10
(2E)-4,6-dihydroxy-2-(4-hydroxybenzylidene)-1-benzofuran-3(2H)-one
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aurone derivative isolated from plant extract. Comparison with inhibition of 5'-deiodinase EC 1.97.1.10
(4-[(E)-(4,6-dihydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)methyl]phenoxy)acetic acid
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aurone derivative isolated from plant extract. Comparison with inhibition of 5'-deiodinase EC 1.97.1.10
2-(3,4-dihydroxybenzyl)-4,6-dihydroxy-1-benzofuran-3(2H)-one
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aurone derivative isolated from plant extract. Comparison with inhibition of 5'-deiodinase EC 1.97.1.10
3',4',4,6-tetrahydroxyaurone
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inhibition kinetics; very potent naturally occuring plant-derived inhibitor, conformation study
3,5,3'-triiodo-5'-nitrothyronine
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comparison with 5'-deiodinase EC 1.97.1.10
3,5,5'-triiodo-2'-methylthyronine
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comparison with 5'-deiodinase EC 1.97.1.10
3,5-diiodo-2'-hydroxythyronine
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comparison with 5'-deiodinase EC 1.97.1.10
3,5-diiodo-3',5'-dinitrothyronine
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comparison with 5'-deiodinase EC 1.97.1.10
3,5-diiodo-3'-hydroxythyronine
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comparison with 5'-deiodinase EC 1.97.1.10
3,5-diiodo-4'-amino-3',5'-dimethylthyronine
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comparison with 5'-deiodinase EC 1.97.1.10
4',4,6-trihydroxyaurone
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cofactor competitive mechanism, displacement of thyroxine from the binding site of thyroxine-binding prealbumin; inhibition kinetics; very potent naturally occuring plant-derived inhibitor
6-n-propyl-2-thiouracil
type 3 iodothyronine deiodinase is unaffected by PTU
growth hormone
upregulates the 5-deiodinase mRNA expression in the tail, but downregulates it in the liver
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N-acetyl-3,5,3'-triiodo-5'-nitrothyronine
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comparison with 5'-deiodinase EC 1.97.1.10
N-acetyl-3,5-diiodo-3',5'-dinitrothyronine
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comparison with 5'-deiodinase EC 1.97.1.10
N-acetyl-3,5-diiodo-3'-bromo-5'-nitrothyronine
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comparison with 5'-deiodinase EC 1.97.1.10
prolactin
inhibits the 3,3',5-triiodo-L-thyronine-dependent upregulation of thyroid hormone receptor beta mRNA expression in the tail; inhibits the regression of the tail fin; upregulates the 5-deiodinase mRNA expression in the tail, but downregulates it in the liver
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propylthiouracil
slight inhibition of recombinant and native isozyme type III
[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]acetic acid
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comparison with 5'-deiodinase EC 1.97.1.10
[4-(4-hydroxy-3,5-dinitrophenoxy)-3,5-diiodophenyl]acetic acid
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comparison with 5'-deiodinase EC 1.97.1.10
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)-3,5-diiodophenyl]acetic acid
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comparison with 5'-deiodinase EC 1.97.1.10
[4-(4-hydroxy-3-iodo-5-nitrophenoxy)phenyl]acetic acid
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comparison with 5'-deiodinase EC 1.97.1.10
3,3',5'-triiodo-L-thyronine
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75% inhibition at 0.01 mM; substrate inhibition
3,3',5,5'-tetraiodo-L-thyronine
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95% substrate inhibition at 0.001 mM
3,3',5-triiodo-L-thyronine
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substrate inhibition of isozyme type III, complete inhibition at 25 nM
3,3',5-triiodo-L-thyronine
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substrate inhibition, completely at 0.001 mM
3,5-diiodo-L-thyronine
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75% inhibition of 3,3'-diiodo-L-thyronine formation at 0.001 mM
N-bromoacetyl-3,3',5-triiodo-L-thyronine
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irreversible inactivation; isozyme type III; reacts with the selenocysteine residue in the active site
N-bromoacetyl-3,3',5-triiodo-L-thyronine
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irreversible inactivation; isozyme type III; reacts with the selenocysteine residue in the active site
additional information
the measured zD3 activity is unaffected by 1 mM propylthiouracil
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additional information
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no inhibition of 5-deiodinase activity by propylthiouracil
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additional information
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3,3',5-triiodo-L-thyronine sulfate has no effect on isozyme type III in hippocampus up to 100 nM
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additional information
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expression and function of the 5-deiodinase and 5-deiodinase isozymes are sensitive to thyroid hormone status, various cytokines and growth factors, severe illness, reactive oxygen species, a variety of hormones and signaling compounds, circadian rythm, and pharmacological agents, and therefore might be useful in sensor function of physiology and pathophysiology
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additional information
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decrease of deiodination about 50% in cells with knockdown of peroxiredoxin 3
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additional information
no inhibition of 5-deiodinase activity by propylthiouracil
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