Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Phospholipids | no influence on the kinetic parameters of 5-deiodinase activity of isozyme type III in placenta, but essential for activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Phospholipids | no inhibition of placental isozyme type III | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics, isozyme type III | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | isozyme type III | Rattus norvegicus | - |
- |
mitochondrion | isozyme type III | Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | placental isozyme type III is only slightly increased in hyperthyroidism, while brain isozyme type III is strongly induced | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Rattus norvegicus | - |
isozyme type III | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | isozyme type III | Rattus norvegicus | - |
cerebral cortex | isozyme type III | Rattus norvegicus | - |
placenta | isozyme type III | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity in hyperthyroid and control rats at different substrate concentrations | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3,3',5-triiodo-L-thyronine + AH2 | best substrate | Rattus norvegicus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
3,3',5-triiodo-L-thyronine + AH2 | isozyme type III | Rattus norvegicus | 3,3'-diiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | preferred substrate | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | isozyme type III | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
L-thyroxine + AH2 | 5-deiodinase activity | Rattus norvegicus | 3,3',5'-triiodo-L-thyronine + iodide + A + H+ | - |
? | |
additional information | placental isozyme type III is only slightly increased in hyperthyroidism, while brain isozyme type III is strongly induced | Rattus norvegicus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |