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Information on EC 3.6.4.6 - vesicle-fusing ATPase

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IUBMB Comments
A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (_A_TPase _a_ssociated with a variety of cell _a_ctivities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger's syndrome.
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Word Map
  • 3.6.4.6
  • snare
  • ouabain
  • na+
  • exocytosis
  • syntaxins
  • endosomal
  • alpha1
  • snap-25
  • disassembly
  • basolateral
  • alpha-subunits
  • proteasome
  • ouabain-sensitive
  • atpases
  • vesicle-associated
  • synaptotagmins
  • reabsorption
  • beta-subunits
  • presynaptic
  • nephron
  • synaptobrevin
  • t-snares
  • bilayer
  • aldosterone
  • er-associated
  • electrogenic
  • cardiotonic
  • escrts
  • p-type
  • ouabain-induced
  • botulinum
  • homotypic
  • multivesicular
  • digoxin
  • phosphoenzyme
  • proteoliposomes
  • synaptosomal-associated
  • exocytic
  • exocyst
  • sodium-potassium
  • ca-atpase
  • reticulum-associated
  • sarcolemmal
  • medicine
  • bonts
  • k+-dependent
  • k+-free
  • digitalis
  • p-nitrophenylphosphatase
  • h,k-atpase
  • rubidium
The expected taxonomic range for this enzyme is: Eukaryota, Archaea
Reaction Schemes
Synonyms
n-ethylmaleimide-sensitive factor, cdc48, aaa-atpase, n-ethylmaleimide-sensitive fusion protein, sec18p, n-ethylmaleimide sensitive factor, cdc48p, sec18, pex1p, pex6p, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O = ADP + phosphate
show the reaction diagram
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