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Literature summary for 3.6.4.6 extracted from
- Cellular functions of NSF: not just SNAPs and SNAREs (2007), FEBS Lett., 581, 2140-2149.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E329Q | hydrolysis mutant | Saccharomyces cerevisiae |
| E350Q | hydrolysis mutant | Saccharomyces cerevisiae |
| G282E | mutant protein has no ATPase activity | Mammalia |
| K266A | ATP-binding mutant | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| Golgi membrane | NSF requires a peripheral membrane protein to bind Golgi membranes | Drosophila melanogaster | 139 | - |
| Golgi membrane | NSF requires a peripheral membrane protein to bind Golgi membranes | Mammalia | 139 | - |
| Golgi membrane | NSF requires a peripheral membrane protein to bind Golgi membranes | Rattus norvegicus | 139 | - |
| Golgi membrane | NSF requires a peripheral membrane protein to bind Golgi membranes | Saccharomyces cerevisiae | 139 | - |
| synaptosome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Drosophila melanogaster |  |
| Mg2+ | - |
Mammalia | |
| Mg2+ | - |
Rattus norvegicus | |
| Mg2+ | - |
Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Drosophila melanogaster | - |
ADP + phosphate | - |
ir | |
| ATP + H2O | Mammalia | - |
ADP + phosphate | - |
ir | |
| ATP + H2O | Rattus norvegicus | - |
ADP + phosphate | - |
ir | |
| ATP + H2O | Saccharomyces cerevisiae | - |
ADP + phosphate | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
| Drosophila melanogaster | P46461 | - |
- |
| Mammalia | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| central nervous system | - |
Drosophila melanogaster | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Drosophila melanogaster | ADP + phosphate | - |
ir | |
| ATP + H2O | - |
Mammalia | ADP + phosphate | - |
ir | |
| ATP + H2O | - |
Rattus norvegicus | ADP + phosphate | - |
ir | |
| ATP + H2O | - |
Saccharomyces cerevisiae | ADP + phosphate | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homohexamer | - |
Drosophila melanogaster |
| homohexamer | - |
Mammalia |
| homohexamer | - |
Rattus norvegicus |
| homohexamer | - |
Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dNSF1 | isoform 1 | Drosophila melanogaster |
| dNSF1 | isoform 2 | Drosophila melanogaster |
| N-ethylmaleimide sensitive factor | - |
Drosophila melanogaster |
| N-ethylmaleimide sensitive factor | - |
Mammalia |
| N-ethylmaleimide sensitive factor | - |
Rattus norvegicus |
| N-ethylmaleimide sensitive factor | - |
Saccharomyces cerevisiae |
| NSF | - |
Drosophila melanogaster |
| NSF | - |
Mammalia |
| NSF | - |
Rattus norvegicus |
| NSF | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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