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Literature summary for 3.6.4.6 extracted from

  • Tamura, S.; Shimozawa, N.; Suzuki, Y.; Tsukamoto, T.; Osumi, T.; Fujiki, Y.
    A cytoplasmic AAA family peroxin, Pex1p, interacts with Pex6p (1998), Biochem. Biophys. Res. Commun., 245, 883-886.
    View publication on PubMed
Search for more literature for 3.6.4.6

Application

Application Comment Organism
medicine HsPEX1 is the causative gene for peroxisome-deficiency autosomal recessive disorders like cerebro-hepato-renal Zellweger syndrome, neonatal adrenoleukodystrophy and infantile refsum disease Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
isolation of PEX2 and PEX6 cDNA, Pex1p expressed in wild-type chinese hamster ovary cells, CHO-K1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
cytoplasm
-
 Rattus norvegicus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
143000
-
 Pex1p Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Homo sapiens
-
 ADP + phosphate
-
 ?
ATP + H2O Rattus norvegicus
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
 rat
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O = ADP + phosphate large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. Homo sapiens
a
ATP + H2O = ADP + phosphate large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast from PBD patients Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?
ATP + H2O
-
 Rattus norvegicus ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
HsPEX1
-
 Homo sapiens
HsPex6p
-
 Homo sapiens
rat Pex6p
-
 Rattus norvegicus