Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 3.6.4.6 - vesicle-fusing ATPase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Confalonieri, F.; Duguet, M.
A 200-amino acid ATPase module in search of a basic function
Bioessays
17
639-650
1995
Saccharomyces cerevisiae, Candida albicans, Cricetulus longicaudatus, Drosophila melanogaster, Homo sapiens, Mus musculus, Sulfolobus acidocaldarius, Xenopus laevis
Manually annotated by BRENDA team
Finken-Eigen, M.; Roehricht, R.A.; Koehrer, K.
The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment
Curr. Genet.
31
469-480
1997
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Schizosaccharomyces pombe
Manually annotated by BRENDA team
Babst, M.; Sato, T.K.; Banta, L.M.; Emr, S.D.
Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p
EMBO J.
16
1820-1831
1997
Homo sapiens, Mus musculus, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Manually annotated by BRENDA team
Patel, S.; Latterich, M.
The AAA team: related ATPases with diverse functions
Trends Cell Biol.
8
65-71
1998
Saccharomyces cerevisiae, Mus musculus, Drosophila melanogaster (P54351)
Manually annotated by BRENDA team
Faber, K.N.; Heyman, J.A.; Subramani, S.
Two AAA family peroxins, PpPex1p and PpPex6p, interact with each other in an ATP-dependent manner and are associated with different subcellular membranous structures distinct from peroxisomes
Mol. Cell. Biol.
18
936-943
1998
Homo sapiens, Komagataella pastoris
Manually annotated by BRENDA team
Tamura, S.; Shimozawa, N.; Suzuki, Y.; Tsukamoto, T.; Osumi, T.; Fujiki, Y.
A cytoplasmic AAA family peroxin, Pex1p, interacts with Pex6p
Biochem. Biophys. Res. Commun.
245
883-886
1998
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Babst, M.; Wendland, B.; Estepa, E.J.; Emr, S.D.
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function
EMBO J.
17
2982-2993
1998
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Imamura, A.; Tamura, S.; Shimozawa, N.; Suzuki, Y.; Zhang, Z.; Tsukamoto, T.; Orii, T.; Kondo, N.; Osumi, T.; Fujiki, Y.
Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders
Hum. Mol. Genet.
7
2089-2094
1998
Homo sapiens
Manually annotated by BRENDA team
Meyer, H.H.; Kondo, H.; Warren, G.
The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97
FEBS Lett.
437
255-257
1998
Saccharomyces cerevisiae, Rattus norvegicus, Xenopus laevis
Manually annotated by BRENDA team
Yoshimori, T.; Yamagata, F.; Yamamoto, A.; Mizushima, N.; Kabeya, Y.; Nara, A.; Miwako, I.; Ohashi, M.; Ohsumi, M.; Ohsumi, Y.
The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells
Mol. Biol.
11
747-763
2000
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Collins, C.S.; Kalish, J.E.; Morrell, J.C.; McCaffery, J.M.; Gould, S.J.
The peroxisome biogenesis factors pex4p, pex22p, pex1p, and pex6p act in the terminal steps of peroxisomal matrix protein import
Mol. Cell. Biol.
20
7516-7526
2000
Komagataella pastoris
Manually annotated by BRENDA team
Horsnell, W.G.; Steel, G.J.; Morgan, A.
Analysis of NSF mutants reveals residues involved in SNAP binding and ATPase stimulation
Biochemistry
41
5230-5235
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Uchiyama, K.; Jokitalo, E.; Kano, F.; Murata, M.; Zhang, X.; Canas, B.; Newman, R.; Rabouille, C.; Pappin, D.; Freemont, P.; Kondo, H.
VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo
J. Cell Biol.
159
855-866
2002
Rattus norvegicus
Manually annotated by BRENDA team
Yeo, S.C.; Xu, L.; Ren, J.; Boulton, V.J.; Wagle, M.D.; Liu, C.; Ren, G.; Wong, P.; Zahn, R.; Sasajala, P.; Yang, H.; Piper, R.C.; Munn, A.L.
Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae
J. Cell Sci.
116
3957-3970
2003
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Fujita, H.; Umezuki, Y.; Imamura, K.; Ishikawa, D.; Uchimura, S.; Nara, A.; Yoshimori, T.; Hayashizaki, Y.; Kawai, J.; Ishidoh, K.; Tanaka, Y.; Himeno, M.
Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B
J. Cell Sci.
117
2997-3009
2004
Mus musculus
Manually annotated by BRENDA team
Mohtashami, M.; Stewart, B.A.; Boulianne, G.L.; Trimble, W.S.
Analysis of the mutant Drosophila N-ethylmaleimide sensitive fusion-1 protein in comatose reveals molecular correlates of the behavioural paralysis
J. Neurochem.
77
1407-1417
2001
Drosophila melanogaster
Manually annotated by BRENDA team
Whiteheart, S.W.; Matveeva, E.A.
Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor
J. Struct. Biol.
146
32-43
2004
Homo sapiens
Manually annotated by BRENDA team
Dalal, S.; Rosser, M.F.N.; Cyr, D.M.; Hanson, P.I.
Distinct roles for the AAA ATPases NSF and p97 in the secretory pathway
Mol. Biol. Cell
15
637-648
2004
Cricetulus griseus, Mus musculus
Manually annotated by BRENDA team
Liu, C.; Hu, B.
Alterations of N-ethylmaleimide-sensitive ATPase following transient cerebral ischemia
Neuroscience
128
767-774
2004
Rattus norvegicus
Manually annotated by BRENDA team
Littleton, J.T.; Barnard, R.J.; Titus, S.A.; Slind, J.; Chapman, E.R.; Ganetzky, B.
SNARE-complex disassembly by NSF follows synaptic-vesicle fusion
Proc. Natl. Acad. Sci. USA
98
12233-12238
2001
Drosophila melanogaster
Manually annotated by BRENDA team
Shiozawa Kumik, S.K.; Maita Nobu, M.N.; Tomii Kentar, T.K.; Seto Azus, S.A.; Goda Natsuk, G.N.; Akiyama Yutak, A.Y.; Shimizu Toshiyuk, S.T.; Shirakawa Masahir, S.M.; Hiroaki Hidekaz, H.H.
Crystallographic characterization of the N-terminal domain of PEX1
Acta Crystallogr. Sect. D
60
2098-2099
2004
Mus musculus
Manually annotated by BRENDA team
Ramalho-Santos, J.; Schatten, G.
Presence of N-ethyl maleimide sensitive factor (NSF) on the acrosome of mammalian sperm
Arch. Androl.
50
163-168
2004
Bos taurus, Mus musculus
Manually annotated by BRENDA team
Fan, W.; Fujiki, Y.
A temperature-sensitive CHO pex1 mutant with a novel mutation in the AAA Walker A1 motif
Biochem. Biophys. Res. Commun.
345
1434-1439
2006
Cricetulus griseus
Manually annotated by BRENDA team
Yamauchi, S.; Yamanaka, K.; Ogura, T.
Comparative analysis of expression of two p97 homologues in Caenorhabditis elegans
Biochem. Biophys. Res. Commun.
345
746-753
2006
Caenorhabditis elegans
Manually annotated by BRENDA team
Xu, W.; Zhang, Q.; Denlinger, D.L.
A novel member of the NSF family in the corn earworm, Helicoverpa zea: molecular cloning, developmental expression, and tissue distribution
Biochim. Biophys. Acta
1759
186-190
2006
Helicoverpa zea
Manually annotated by BRENDA team
Woods, I.G.; Lyons, D.A.; Voas, M.G.; Pogoda, H.M.; Talbot, W.S.
nsf is essential for organization of myelinated axons in zebrafish
Curr. Biol.
16
636-648
2006
Danio rerio
Manually annotated by BRENDA team
Choi Jaebo, C.J.; Richards Keri , R.K.; Cinar Hediye Nes, C.H.; Newman Anna , N.A.
N-ethylmaleimide sensitive factor is required for fusion of the C. elegans uterine anchor cell
Dev. Biol.
297
87-102
2006
Caenorhabditis elegans
Manually annotated by BRENDA team
Pontier, S.M.; Lahaie, N.; Ginham, R.; St-Gelais, F.; Bonin, H.; Bell, D.J.; Flynn, H.; Trudeau, L.E.; McIlhinney, J.; White, J.H.; Bouvier, M.
Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy
EMBO J.
25
2698-2709
2006
Rattus norvegicus
Manually annotated by BRENDA team
Vajjhala, P.R.; Wong, J.S.; To, H.Y.; Munn, A.L.
The beta domain is required for Vps4p oligomerization into a functionally active ATPase
FEBS J.
273
2357-2373
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Rosenkranz, K.; Birschmann, I.; Grunau, S.; Girzalsky, W.; Kunau, W.H.; Erdmann, R.
Functional association of the AAA complex and the peroxisomal importomer
FEBS J.
273
3804-3815
2006
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Shiozawa Kumik, S.K.; Goda Natsuk, G.N.; Shimizu Toshiyuk, S.T.; Mizuguchi Kenj, M.K.; Kondo Naom, K.N.; Shimozawa Nobuyuk, S.N.; Shirakawa Masahir, S.M.; Hiroaki Hidekaz, H.H.
The common phospholipid-binding activity of the N-terminal domains of PEX1 and VCP/p97
FEBS J.
273
4959-4971
2006
Mus musculus
Manually annotated by BRENDA team
Laviolette, M.J.; Nunes, P.; Peyre, J.B.; Aigaki, T.; Stewart, B.A.
A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth
Genetics
170
779-792
2005
Drosophila sp. (in: flies)
Manually annotated by BRENDA team
Cui, S.Y.; Zhang, W.Q.; Xu, W.H.
Spatial and temporal expression of N-ethylmaleimide-sensitive factor gene in the nervous system of the cotton bollworm, Helicoverpa armigera
Insect Biochem. Mol. Biol.
36
603-609
2006
Helicoverpa armigera
Manually annotated by BRENDA team
Tamura, S.; Yasutake, S.; Matsumoto, N.; Fujiki, Y.
Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p
J. Biol. Chem.
281
27693-27704
2006
Homo sapiens
Manually annotated by BRENDA team
Martin, H.G.; Henley, J.M.; Meyer, G.
Novel putative targets of N-ethylmaleimide sensitive fusion protein (NSF) and alpha/beta soluble NSF attachment proteins (SNAPs) include the Pak-binding nucleotide exchange factor betaPIX
J. Cell. Biochem.
99
1203-1215
2006
Rattus norvegicus
Manually annotated by BRENDA team
Morrell, C.N.; Matsushita, K.; Lowenstein, C.J.
A novel inhibitor of N-ethylmaleimide-sensitive factor decreases leukocyte trafficking and peritonitis
J. Pharmacol. Exp. Ther.
314
155-161
2005
Mus musculus
Manually annotated by BRENDA team
Yamanaka, K.; Okubo, Y.; Suzaki, T.; Ogura, T.
Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation
J. Struct. Biol.
146
242-250
2004
Caenorhabditis elegans
Manually annotated by BRENDA team
Steinberg, J.P.; Huganir, R.L.; Linden, D.J.
N-ethylmaleimide-sensitive factor is required for the synaptic incorporation and removal of AMPA receptors during cerebellar long-term depression
Proc. Natl. Acad. Sci. USA
101
18212-18216
2004
Mus musculus
Manually annotated by BRENDA team
Platta, H.W.; Debelyy, M.O.; El Magraoui, F.; Erdmann, R.
The AAA peroxins Pex1p and Pex6p function as dislocases for the ubiquitinated peroxisomal import receptor Pex5p
Biochem. Soc. Trans.
36
99-104
2008
Homo sapiens
Manually annotated by BRENDA team
Beuron, F.; Dreveny, I.; Yuan, X.; Pye, V.E.; McKeown, C.; Briggs, L.C.; Cliff, M.J.; Kaneko, Y.; Wallis, R.; Isaacson, R.L.; Ladbury, J.E.; Matthews, S.J.; Kondo, H.; Zhang, X.; Freemont, P.S.
Conformational changes in the AAA ATPase p97-p47 adaptor complex
EMBO J.
25
1967-1976
2006
Rattus norvegicus
Manually annotated by BRENDA team
Jung, C.H.; Yang, Y.S.; Kim, J.S.; Shin, J.I.; Jin, Y.S.; Shin, J.Y.; Lee, J.H.; Chung, K.M.; Hwang, J.S.; Oh, J.M.; Shin, Y.K.; Kweon, D.H.
A search for synthetic peptides that inhibit soluble N-ethylmaleimide sensitive-factor attachment receptor-mediated membrane fusion
FEBS J.
275
3051-3063
2008
Rattus norvegicus
Manually annotated by BRENDA team
Zhao, C.; Slevin, J.T.; Whiteheart, S.W.
Cellular functions of NSF: not just SNAPs and SNAREs
FEBS Lett.
581
2140-2149
2007
Saccharomyces cerevisiae, Drosophila melanogaster, Drosophila melanogaster (P46461), Mammalia, Rattus norvegicus
Manually annotated by BRENDA team
Liu, Y.; Cheng, K.; Gong, K.; Fu, A.K.; Ip, N.Y.
Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis
J. Biol. Chem.
281
9852-9858
2006
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Oh, E.; Heise, C.J.; English, J.M.; Cobb, M.H.; Thurmond, D.C.
WNK1 is a novel regulator of Munc18c-syntaxin 4 complex formation in soluble NSF attachment protein receptor (SNARE)-mediated vesicle exocytosis
J. Biol. Chem.
282
32613-32622
2007
Mus musculus
Manually annotated by BRENDA team
Hanley, J.G.
NSF binds calcium to regulate its interaction with AMPA receptor subunit GluR2
J. Neurochem.
101
1644-1650
2007
Mammalia
Manually annotated by BRENDA team
Pye, V.E.; Dreveny, I.; Briggs, L.C.; Sands, C.; Beuron, F.; Zhang, X.; Freemont, P.S.
Going through the motions: The ATPase cycle of p97
J. Struct. Biol.
156
12-28
2006
Arabidopsis thaliana, Archaea, Saccharomyces cerevisiae, Drosophila melanogaster, protozoa
Manually annotated by BRENDA team
Cui, S.Y.; Xu, W.H.
Molecular characterization and functional distribution of N-ethylmaleimide-sensitive factor in Helicoverpa armigera
Peptides
27
1226-1234
2006
Helicoverpa armigera
Manually annotated by BRENDA team
Haas, T.J.; Sliwinski, M.K.; Martinez, D.E.; Preuss, M.; Ebine, K.; Ueda, T.; Nielsen, E.; Odorizzi, G.; Otegui, M.S.
The Arabidopsis AAA ATPase SKD1 is involved in multivesicular endosome function and interacts with its positive regulator lyst-interacting protein5
Plant Cell
19
1295-1312
2007
Arabidopsis thaliana
Manually annotated by BRENDA team
Briggs, L.C.; Baldwin, G.S.; Miyata, N.; Kondo, H.; Zhang, X.; Freemont, P.S.
Analysis of nucleotide binding to p97 reveals the properties of a tandem AAA hexameric ATPase
J. Biol. Chem.
283
13745-13752
2008
Rattus norvegicus (P46462)
Manually annotated by BRENDA team
Fisher, E.A.; Lapierre, L.R.; Junkins, R.D.; McLeod, R.S.
The AAA-ATPase p97 facilitates degradation of apolipoprotein B by the ubiquitin-proteasome pathway
J. Lipid Res.
49
2149-2160
2008
Homo sapiens
Manually annotated by BRENDA team
Hartmann, C.; Chami, M.; Zachariae, U.; de Groot, B.L.; Engel, A.; Gruetter, M.G.
Vacuolar protein sorting: two different functional states of the AAA-ATPase Vps4p
J. Mol. Biol.
377
352-363
2008
Saccharomyces cerevisiae (P52917), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Yu, Z.; Gonciarz, M.D.; Sundquist, W.I.; Hill, C.P.; Jensen, G.J.
Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p
J. Mol. Biol.
377
364-377
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Inoue, M.; Kamikubo, H.; Kataoka, M.; Kato, R.; Yoshimori, T.; Wakatsuki, S.; Kawasaki, M.
Nucleotide-dependent conformational changes and assembly of the AAA ATPase SKD1/VPS4B
Traffic
9
2180-2189
2008
Mus musculus (P46467)
Manually annotated by BRENDA team
Naydenov, N.G.; Harris, G.; Brown, B.; Schaefer, K.L.; Das, S.K.; Fisher, P.B.; Ivanov, A.I.
Loss of soluble N-ethylmaleimide-sensitive factor attachment protein alpha (alphaSNAP) induces epithelial cell apoptosis via down-regulation of Bcl-2 expression and disruption of the Golgi
J. Biol. Chem.
287
5928-5941
2012
Homo sapiens
Manually annotated by BRENDA team
Chang, L.F.; Chen, S.; Liu, C.C.; Pan, X.; Jiang, J.; Bai, X.C.; Xie, X.; Wang, H.W.; Sui, S.F.
Structural characterization of full-length NSF and 20S particles
Nat. Struct. Mol. Biol.
19
268-275
2012
Cricetinae
Manually annotated by BRENDA team
Hill, C.P.; Babst, M.
Structure and function of the membrane deformation AAA ATPase Vps4
Biochim. Biophys. Acta
1823
172-181
2012
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Monroe, N.; Han, H.; M.D., Gonciarz; Eckert, D.M.; Karren, M.A.; Whitby, F.G.; Sundquist, W.I.; Hill, C.P.
The oligomeric state of the active Vps4 AAA ATPase
J. Mol. Biol.
426
510-525
2013
Saccharomyces cerevisiae, Saccharolobus solfataricus (Q97ZJ7), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q97ZJ7)
Manually annotated by BRENDA team
Legent, K.; Liu, H.H.; Treisman, J.E.
Drosophila Vps4 promotes epidermal growth factor receptor signaling independently of its role in receptor degradation
Development
142
1480-1491
2015
Drosophila melanogaster (Q9Y162)
Manually annotated by BRENDA team
Vivona, S.; Cipriano, D.J.; OLeary, S.; Li, Y.H.; Fenn, T.D.; Brunger, A.T.
Disassembly of all SNARE complexes by N-ethylmaleimide-sensitive factor (NSF) is initiated by a conserved 1:1 interaction between alpha-soluble NSF attachment protein (SNAP) and SNARE complex
J. Biol. Chem.
288
24984-24991
2013
Cricetulus griseus
Manually annotated by BRENDA team
Han, H.; Monroe, N.; Votteler, J.; Shakya, B.; Sundquist, W.I.; Hill, C.P.
Binding of substrates to the central pore of the Vps4 ATPase is autoinhibited by the microtubule interacting and trafficking (MIT) domain and activated by MIT interacting motifs (MIMs)
J. Biol. Chem.
290
13490-13499
2015
Saccharomyces cerevisiae (P52917)
Manually annotated by BRENDA team
Wang, F.; Yang, Y.; Wang, Z.; Zhou, J.; Fan, B.; Chen, Z.
A critical role of Lyst-interacting protein5, a positive regulator of multivesicular body biogenesis, in plant responses to heat and salt stresses
Plant Physiol.
169
497-511
2015
Arabidopsis thaliana (Q9ZNT0)
Manually annotated by BRENDA team
Barajas, D.; Martin, I.F.; Pogany, J.; Risco, C.; Nagy, P.D.
Noncanonical role for the host Vps4 AAA+ ATPase ESCRT protein in the formation of Tomato bushy stunt virus replicase
PLoS Pathog.
10
e1004087
2014
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Manually annotated by BRENDA team
Xia, Y.; Liu, N.; Xie, X.; Bi, G.; Ba, H.; Li, L.; Zhang, J.; Deng, X.; Yao, Y.; Tang, Z.; Yin, B.; Wang, J.; Jiang, K.; Li, Z.; Choi, Y.; Gong, F.; Cheng, X.; OShea, J.J.; Chae, J.J.; Laurence, A.; Yang, X.P.
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion
Autophagy
15
960-975
2019
Mus musculus
Manually annotated by BRENDA team
Caillat, C.; Maity, S.; Miguet, N.; Roos, W.H.; Weissenhorn, W.
The role of VPS4 in ESCRT-III polymer remodeling
Biochem. Soc. Trans.
47
441-448
2019
Homo sapiens
Manually annotated by BRENDA team
Rijal, R.; Arhzaouy, K.; Strucksberg, K.; Cross, M.; Hofmann, A.; Schroeder, R.; Clemen, C.; Eichinger, L.
Mutant p97 exhibits species-specific changes of its ATPase activity and compromises the UBXD9-mediated monomerisation of p97 hexamers
Eur. J. Cell Biol.
95
195-207
2016
Homo sapiens (P55072), Homo sapiens, Dictyostelium discoideum (Q75JI3)
Manually annotated by BRENDA team
Alonso Y Adell, M.; Migliano, S.M.; Teis, D.
ESCRT-III and Vps4 a dynamic multipurpose tool for membrane budding and scission
FEBS J.
283
3288-3302
2016
Homo sapiens
Manually annotated by BRENDA team
Tan, J.; Davies, B.A.; Payne, J.A.; Benson, L.M.; Katzmann, D.J.
Conformational changes in the endosomal sorting complex required for the Transport III subunit ist1 lead to distinct modes of ATPpase Vps4 regulation
J. Biol. Chem.
290
30053-30065
2015
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Schoeneberg, J.; Pavlin, M.R.; Yan, S.; Righini, M.; Lee, I.H.; Carlson, L.A.; Bahrami, A.H.; Goldman, D.H.; Ren, X.; Hummer, G.; Bustamante, C.; Hurley, J.H.
ATP-dependent force generation and membrane scission by ESCRT-III and Vps4
Science
362
1423-1428
2018
Homo sapiens
Manually annotated by BRENDA team