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Information on EC 3.6.1.62 - 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] hydrolase

for references in articles please use BRENDA:EC3.6.1.62
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IUBMB Comments
Decapping of mRNA is a critical step in eukaryotic mRNA turnover. The enzyme is unable to cleave a free cap structure (m7GpppG) . The enzyme from Vaccinia virus is synergistically activated in the presence of Mg2+ and Mn2+ .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
nudt16, hdcp2, hnudt16, d10 protein, d10 decapping enzyme, x29 protein, d9 protein, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
a 5'-(N7-methylguanosine 5'-triphospho)-[mRNA] + H2O = N7-methylguanosine 5'-diphosphate + a 5'-phospho-[mRNA]
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