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Literature summary for 3.6.1.62 extracted from

  • Xu, J.; Yang, J.Y.; Niu, Q.W.; Chua, N.H.
    Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development (2006), Plant Cell, 18, 3386-3398.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.62

Activating Compound

Activating Compound Comment Organism Structure
DCP1 protein DCP2 interacts in vitro and in vivo with DCP1 and VARICOSE (VCS). The interacting proteins stimulate DCP2 activity, suggesting that the three proteins operate as a decapping complex. DCP1, DCP2, and VCS colocalize in cytoplasmic foci Arabidopsis thaliana
VARICOSE protein DCP2 interacts in vitro and in vivo with DCP1 and VARICOSE (VCS). The interacting proteins stimulate DCP2 activity, suggesting that the three proteins operate as a decapping complex. DCP1, DCP2, and VCS colocalize in cytoplasmic foci Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm DCP1 and the interacting proteins, DCP2, and VCS colocalize in cytoplasmic foci Arabidopsis thaliana 5737
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
m7G5'ppp5'-mRNA + H2O Arabidopsis thaliana DCP2 and the interacting proteins DCP1, and VCS form a decapping complex in vivo. mRNA turnover mediated by the decapping complex is required for postembryonic development in Arabidopsis m7GDP + 5'-phospho-mRNA
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 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
m7G5'ppp5'-mRNA + H2O
-
 Arabidopsis thaliana m7GDP + 5'-phospho-mRNA
-
 ?
m7G5'ppp5'-mRNA + H2O DCP2 and the interacting proteins DCP1, and VCS form a decapping complex in vivo. mRNA turnover mediated by the decapping complex is required for postembryonic development in Arabidopsis Arabidopsis thaliana m7GDP + 5'-phospho-mRNA
-
 ?
m7G5'ppp5'-mRNA + H2O DCP2 and the interacting proteins DCP1, and VCS form a decapping complex in vivo. Each component is required for mRNA decapping during postembryonic development Arabidopsis thaliana m7GDP + 5'-phospho-mRNA
-
 ?

Subunits

Subunits Comment Organism
More DCP2 and the interacting proteins DCP1, and VCS form a decapping complex in vivo. Each component is required for mRNA decapping during postembryonic development Arabidopsis thaliana

Synonyms

Synonyms Comment Organism
Dcp2
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 Arabidopsis thaliana

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Arabidopsis thaliana

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction null mutants of DCP1 accumulate capped mRNAs with a reduced degradation rate. Lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology Arabidopsis thaliana