Reference on EC 3.4.19.3 - pyroglutamyl-peptidase I
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Capecchi, J.T.; Loudon, G.M.
Substrate specificity of pyroglutamylaminopeptidase
J. Med. Chem.
28
140-143
1985
Bos taurus
O'Connor, B.; O'Cuinn, G.
Purification of and kinetic studies on a narrow specificity synaptosomal membrane pyroglutamate aminopeptidase from guinea-pig brain
Eur. J. Biochem.
150
47-52
1985
Cavia porcellus
O'Connor, B.; O'Cuinn, G.
Some properties of synaptosomal membrane-bound pyroglutamate aminopeptidase from guinea-pig brain
Biochem. Soc. Trans.
3
485-487
1985
Bacillus amyloliquefaciens, Cavia porcellus
-
Tsuru, D.; Nakamura, K.; Yoshimoto, T.; Fujiwara, K.
Pyroglutamate-peptidase from Bacillus amyloliquefaciens. An improved purification method and some properties of the enzyme
Biochim. Biophys. Acta
791
117-122
1984
Bacillus amyloliquefaciens
-
O'Connor, B.; O'Cuinn, G.
Localization of a narrow-specificity thyroliberin hydrolyzing pyroglutamate aminopeptidase in synaptosomal membranes of guinea-pig brain
Eur. J. Biochem.
144
271-278
1984
Cavia porcellus
Browne, P.; O'Cuinn, G.
An evaluation of the role of a pyroglutamyl peptidase, a post-proline cleaving enzyme and a post-proline dipeptidyl amino peptidase, each purified from the soluble fraction of guinea-pig brain, in the degradation of thyroliberin in vitro
Eur. J. Biochem.
137
75-87
1983
Cavia porcellus
Tsuru, D.; Sakabe, K.; Yoshimoto, T.; Fujiwara, K.
Pyroglutamyl peptidase from chicken liver: purification and some properties
J. Pharmacobio-Dyn.
5
859-868
1982
Gallus gallus
Fujiwara, K.; Matsumoto, E.; Kitagawa, T.; Tsuru, D.
Inactivation of pyroglutamyl aminopeptidase by N alpha-carbobenzoxy-L-pyroglutamyl chloromethyl ketone
J. Biochem.
90
433-437
1981
Bacillus amyloliquefaciens
Fujiwara, K.; Kitagawa, T.; Tsuru, D.
Inactivation of pyroglutamyl aminopeptidase by L-pyroglutamyl chloromethyl ketone
Biochim. Biophys. Acta
655
10-16
1981
Bacillus amyloliquefaciens
Fujiwara, K.; Matsumoto, E.; Kitagawa, T.; Tsuru, D.
N-alpha-Carbobenzoxy-pyroglutamyl-diazomethylketone as active-site-directed inhibitor for pyroglutamyl peptidase
Biochim. Biophys. Acta
702
149-154
1980
Bacillus amyloliquefaciens
Fujiwara, K.; Kobayashi, R.; Tsuru, D.
The substrate specificity of pyrrolidone carboxylyl peptidase from Bacillus amyloliquefaciens
Biochim. Biophys. Acta
570
140-148
1979
Bacillus amyloliquefaciens
Exterkate, F.A.
Reversible inhibition of the membrane-bound pyrrolidonecarboxylpeptidase in Streptococcus cremoris, caused by organic solvents
FEMS Microbiol. Lett.
5
111-114
1979
Lactococcus cremoris
-
Taylor, W.L.; Dixon, J.E.
Characterization of a pyroglutamate aminopeptidase from rat serum that degrades thyrotropin-releasing hormone
J. Biol. Chem.
253
6934-6940
1978
Rattus norvegicus
Tsuru, D.; Fujiwara, K.; Kado, K.
Purification and characterization of L-pyrrolidonecarboxylate peptidase from Bacillus amyloliquefaciens
J. Biochem.
84
467-476
1978
Pimelobacter simplex, Bacillus amyloliquefaciens, Niallia circulans, Priestia megaterium, Bacillus subtilis, Paenibacillus polymyxa, Micrococcus luteus, Proteus vulgaris, Pseudomonas aeruginosa
Odagaki, Y.; Hayashi, A.; Okada, K.; Hirotsu, K.; Kabashima, T.; Ito, K.; Yoshimoto, T.; Tsuru, D.; Sato, M.; Clardy, J.
The crystal structure of pyroglutamyl peptidase I from Bacillus amyloliquefaciens reveals a new structure for a cysteine protease
Structure
7
399-411
1999
Bacillus amyloliquefaciens
Armentrout, R.W.; Doolittle, R.F.
Pyrrolidonecarboxylyl peptidase: stabilization and purification
Arch. Biochem. Biophys.
132
80-90
1969
Pseudomonas fluorescens
Le Saux, O.; Gonzales, T.; Robert-Baudouy, J.
Mutational analysis of the active site of Pseudomonas fluorescens pyrrolidone carboxyl peptidase
J. Bacteriol.
178
3308-3313
1996
Pseudomonas fluorescens
Awade, A.; Gonzales, T.; Cleuziat, P.; Baudouy, J.R.
One step purification and characterization of the pyrrolidone carboxyl peptidase of Streptococcus pyogenes over-expressed in Escherichia coli
FEBS Lett.
308
70-74
1992
Streptococcus pyogenes
Gonzales, T.; Robert-Baudouy, J.
Characterization of the pcp gene of Pseudomonas fluorescens and of its product, pyrrolidone carboxyl peptidase (Pcp)
J. Bacteriol.
176
2569-2576
1994
Pseudomonas fluorescens
Cummins, P.M.; O'Connor, B.
Bovine brain pyroglutamyl aminopeptidase (type-1): purification and characterisation of a neuropeptide-inactivating peptidase
Int. J. Biochem. Cell Biol.
28
883-893
1996
Bos taurus
Ogasahara, K.; Nakamura, M.; Nakura, S.; Tsunasawa, S.; Kato, I.; Yoshimoto, T.; Yutani, K.
The unusually slow unfolding rate causes the high stability of pyrrolidone carboxyl peptidase from a hyperthermophile, Pyroccoccus furiosus: equilibrium and kinetic studies of guanidine hydrochloride-induced unfolding and refolding
Biochemistry
37
17537-17544
1998
Bacillus amyloliquefaciens, Pyrococcus furiosus
Bharadwaj, D.; Sinha Roy, M.; Saha, G.; Hati, R.N.
Pyroglutamate aminopeptidase in rat submaxillary gland
Indian J. Biochem. Biophys.
29
442-444
1992
Rattus norvegicus
Gallagher, S.P.; O'Connor, B.
A study of a highly specific pyroglutamyl aminopeptidase type-II from the membrane fraction of bovine brain
Int. J. Biochem. Cell Biol.
30
115-133
1998
Bacillus amyloliquefaciens, Bacillus subtilis, Bos taurus
Awade, A.C.; Cleuziat, P.; Gonzales, T.; Robert-Baudouy, J.
Pyrrolidone carboxyl peptidase (Pcp): An enzyme that removes pyroglutamic acid (pGlu) from pGlu peptides and pGlu-proteins
Proteins Struct. Funct. Genet.
20
34-51
1994
Enterobacter cloacae, Bos taurus, Cavia porcellus, Oryctolagus cuniculus, Enterococcus faecium, Homo sapiens, Pseudomonas fluorescens, Rattus norvegicus, Streptococcus pyogenes, Sus scrofa
Mantle, D.; Lauffart, B.; Gibson, A.
Purification and characterization of leucyl aminopeptidase and pyroglutamyl aminopeptidase from human skeletal muscle
Clin. Chim. Acta
197
35-46
1991
Homo sapiens
Yamada, M.; Mori, M.
Thyrotropin-releasing hormone-degrading enzyme in human serum is classified as type II of pyroglutamyl aminopeptidase: influence of thyroid status
Proc. Soc. Exp. Biol. Med.
194
346-351
1990
Homo sapiens
Gonzales, T.; Awade, A.; Besson, C.; Robert-Baudouy, I.
Purification and characterization of recombinant pyrrolidone carboxyl peptidase of Bacillus subtilis
J. Chromatogr.
584
101-107
1992
Bacillus subtilis
Singleton, M.; Isupov, M.; Littlechild, J.
Crystallization and preliminary X-ray diffraction studies of pyrrolidone carboxyl peptidase from the hyperthermophilic archaeon Thermococcus litoralis
Acta Crystallogr. Sect. D
55
702-703
1999
Thermococcus litoralis
Le Saux, O.; Robert-Baudouy, J.
Pyroglutamic acid and iron regulate the expression of the pcp gene in Pseudomonas fluorescens MFO
FEMS Microbiol. Lett.
155
209-215
1997
Pseudomonas fluorescens, Pseudomonas fluorescens MFO
Sanchez, B.; Alba, F.; Luna, J.D.; Martinez, J.M.; Prieto, I.; Ramirez, M.
Pyroglutamyl peptidase I levels and their left-right distribution in the rat retina and hypothalamus are influenced by light-dark conditions
Brain Res.
731
254-257
1996
Rattus norvegicus
Cleuziat, P.; Awade, A.; Robert-Baudouy, J.
Molecular characterization of pcp, the structural gene encoding the pyrrolidone carboxyl peptidase from Streptococcus pyogenes
Mol. Microbiol.
6
2051-2063
1992
Streptococcus pyogenes
Awade, A.; Cleuziat, P.; Gonzales, T.; Robert-Baudouy, J.
Characterization of the pcp gene encoding the pyrrolidone carboxyl peptidase of Bacillus subtilis
FEBS Lett.
305
67-73
1992
Bacillus subtilis
Ramirez, M.; Sanchez, B.; Arechaga, G.; Garcia, S.; Lardelli, P.; Venzon, D.; de Ganderias, J.M.
Bilateral distribution of aminopeptidase activities in selected structures of a photoneuroendocrine circuit and other rat brain areas
Exp. Clin. Endocrinol.
99
59-63
1992
Rattus norvegicus
Ramirez, M.; Sanchez, B.; Arechaga, G.; Garcia, S.; Lardelli, P.; Venzon, D.; de Gandarias, J.M.
Diurnal variation and left-right distribution of pyroglutamyl peptidase I activity in the rat brain and retina
Acta Endocrinol.
125
570-573
1991
Rattus norvegicus
Cruz, C.; Charli, J.L.; Vargas, M.A.; Joseph-Bravo, P.
Neuronal localization of pyroglutamate aminopeptidase II in primary cultures of fetal mouse brain
J. Neurochem.
56
1594-1601
1991
Mus musculus
Charli, J.L.; Mendez, M.; Vargas, M.A.; Cisneros, M.; Assai, M.; Joseph-Bravo, P.; Wilk, S.
Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices
Neuropeptides
14
191-196
1989
Rattus norvegicus
Scharfmann, R.; Morgat, J.L.; Aratan-Spire, S.
Presence of a particulate thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity in rat liver
Neuroendocrinology
49
442-448
1989
Rattus norvegicus
Court, J.A.; McDermott, J.R.; Gibson, A.M.; Marshall, E.; Bloxham, C.A.; Perry, R.H.; Edwardson, J.A.
Raised thyrotrophin-releasing hormone, pyroglutamylamino peptidase, and proline endopeptidase are present in the spinal cord of wobber mice but not in human motor neurone disease
J. Neurochem.
49
1084-1090
1987
Mus musculus, Rattus norvegicus
Vargas, M.; Mendez, M.; Cisneros, M.; Joseph-Bravo, P.; Charli, J.L.
Regional distribution of the membrane-bound pyrrolidone carboxyl peptidase -degrading thyrotrophin-releasing hormone in rat brain
Neurosci. Lett.
79
311-314
1987
Rattus norvegicus
Singleton, M.; Isupov, M.; Littlechild, J.
X-ray structure of pyrrolidone carboxyl peptidase from the hyperthermophilic archaeon Thermococcus litoralis
Structure Fold. Des.
15
237-244
1999
Thermococcus litoralis
Schilling, S.; Hoffmann, T.; Wermann, M.; Heiser, U.; Wasternack, C.; Demuth, H.U.
Continuous spectrometric assays for glutaminyl cyclase activity
Anal. Biochem.
303
49-56
2002
Bacillus amyloliquefaciens
Kabashima, T.; Li, Y.; Kanada, N.; Ito, K.; Yoshimoto, T.
Enhancement of the thermal stability of pyroglutamyl peptidase I by introduction of an intersubunit disulfide bond
Biochim. Biophys. Acta
1547
214-220
2001
Bacillus amyloliquefaciens
Ogasahara, K.; Khechinashvili, N.N.; Nakamura, M.; Yoshimoto, T.; Yutani, K.
Thermal stability of pyrrolidone carboxyl peptidases from the hyperthermophilic archaeon, Pyrococcus furiosus
Eur. J. Biochem.
268
3233-3242
2001
Pyrococcus furiosus
Alur, H.H.; Desai, R.P.; Mitra, A.K.; Johnston, T.P.
Inhibition of a model protease--pyroglutamate aminopeptidase by a natural oligosaccharide gum from Hakea gibbosa
Int. J. Pharm.
212
171-176
2001
Bos taurus
Tanaka, H.; Chinami, M.; Mizushima, T.; Ogasahara, K.; Ota, M.; Tsukihara, T.; Yutani, K.
X-ray crystalline structures of pyrrolidone carboxyl peptidase from a hyperthermophile, Pyrococcus furiosus, and its Cys-free mutant
J. Biochem.
130
107-118
2001
Pyrococcus furiosus
Ito, K.; Inoue, T.; Takahashi, T.; Huang, H.S.; Esumi, T.; Hatakeyama, S.; Tanaka, N.; Nakamura, K.T.; Yoshimoto, T.
The mechanism of substrate recognition of pyroglutamyl-peptidase I from Bacillus amyloliquefaciens as determined by X-ray crystallography and site-directed mutagenesis
J. Biol. Chem.
276
18557-18562
2001
Bacillus amyloliquefaciens
Kaushik, J.K.; Ogasahara, K.; Yutani, K.
The unusually slow relaxation kinetics of the folding-unfolding of pyrrolidone carboxyl peptidase from a hyperthermophile, Pyrococcus furiosus
J. Mol. Biol.
316
991-1003
2002
Pyrococcus furiosus
Singleton, M.R.; Littlechild, J.A.
Pyrrolidone carboxylpeptidase from Thermococcus litoralis
Methods Enzymol.
330
394-403
2001
Thermococcus litoralis
de Gandarias, J.M.; Irazusta, J.; Gil, J.; Varona, A.; Ortega, F.; Casis, L.
Subcellular ontogeny of brain pyroglutamyl peptidase I
Peptides
21
509-517
2000
Rattus norvegicus
Dando, P.M.; Fortunato, M.; Strand, G.B.; Smith, T.S.; Barrett, A.J.
Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme
Protein Expr. Purif.
28
111-119
2003
Homo sapiens (Q9NXJ5), Homo sapiens
Larrinaga, G.; Callado, L.F.; Agirregoitia, N.; Varona, A.; Gil, J.
Subcellular distribution of membrane-bound aminopeptidases in the human and rat brain
Neurosci. Lett.
383
136-140
2005
Homo sapiens, Rattus norvegicus
Morty, R.E.; Bulau, P.; Pelle, R.; Wilk, S.; Abe, K.
Pyroglutamyl peptidase type I from Trypanosoma brucei: a new virulence factor from African trypanosomes that de-blocks regulatory peptides in the plasma of infected hosts
Biochem. J.
394
635-645
2006
Trypanosoma brucei, Trypanosoma brucei gambiense, Trypanosoma brucei rhodesiense, Trypanosoma brucei brucei (Q4U338)
Kaushik, J.K.; Iimura, S.; Ogasahara, K.; Yamagata, Y.; Segawa, S.; Yutani, K.
Completely buried, non-ion-paired glutamic acid contributes favorably to the conformational stability of pyrrolidone carboxyl peptidases from hyperthermophiles
Biochemistry
45
7100-7112
2006
Pyrococcus furiosus (O73944), Pyrococcus furiosus
Abe, K.; Saito, F.; Yamada, M.; Tokui, T.
Pyroglutamyl aminopeptidase I, as a drug metabolizing enzyme, recognizes xenobiotic substrates containing L-2-oxothiazolidine-4-carboxylic acid
Biol. Pharm. Bull.
27
113-116
2004
Homo sapiens, Mus musculus, Rattus norvegicus
Abe, K.; Fukuda, K.; Tokui, T.
Marginal involvement of pyroglutamyl aminopeptidase I in metabolism of thyrotropin-releasing hormone in rat brain
Biol. Pharm. Bull.
27
1197-1201
2004
Rattus norvegicus (Q76IC5), Mus musculus (Q9ESW8), Mus musculus, Homo sapiens (Q9NXJ5), Homo sapiens
Monsuur, A.J.; Stepniak, D.; Diosdado, B.; Wapenaar, M.C.; Mearin, M.L.; Koning, F.; Wijmenga, C.
Genetic and functional analysis of pyroglutamyl-peptidase I in coeliac disease
Eur. J. Gastroenterol. Hepatol.
18
637-644
2006
Homo sapiens (Q9NXJ5)
Garcia-Lopez, M.J.; Martinez-Martos, J.M.; Mayas, M.D.; Carrera, M.P.; Ramirez-Exposito, M.J.
Effects of orchidectomy and testosterone replacement on mouse pyrrolidone carboxypeptidase activity in the HPA axis
Horm. Metab. Res.
36
131-135
2004
Mus musculus (Q9ESW8), Mus musculus
Carrera, M.P.; Ramirez-Exposito, M.J.; Valenzuela, M.T.; Garcia, M.J.; Mayas, M.D.; De Saavedra, J.M.; Sanchez, R.; Perez, M.C.; Martinez-Martos, J.M.
Pyrrolidon (sic) carboxypeptidase activities in the hypothalamus-pituitary-thyroid and hypothalamus-pituitary-ovary axes of rats with mammary gland cancer induced by N-methyl nitrosourea
Horm. Metab. Res.
37
74-78
2005
Rattus norvegicus
Valdivia, A.; Irazusta, J.; Fernandez, D.; Mugica, J.; Ochoa, C.; Casis, L.
Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia
Regul. Pept.
122
79-84
2004
Homo sapiens
Iimura, S.; Umezaki, T.; Takeuchi, M.; Mizuguchi, M.; Yagi, H.; Ogasahara, K.; Akutsu, H.; Noda, Y.; Segawa, S.; Yutani, K.
Characterization of the denatured structure of pyrrolidone carboxyl peptidase from a hyperthermophile under nondenaturing conditions: role of the C-terminal alpha-helix of the protein in folding and stability
Biochemistry
46
3664-3672
2007
Pyrococcus furiosus (O73944), Pyrococcus furiosus
Hellstroem, J.L.; Vehniaeinen, M.; Mustonen, M.; Loevgren, T.; Lamminmaeki, U.; Hellman, J.
Unfolding of the immunoglobulin light and heavy chains is required for the enzymatic removal of N-terminal pyroglutamyl residues
Biochim. Biophys. Acta
1764
1735-1740
2006
Pyrococcus furiosus
Marinho, C.E.; Olivo, R.d.o.A.; Zambotti-Villela, L.; Ribeiro-de-Andrade, T.N.; Fernandes, C.M.; Silveira, P.F.
Renal and macrophage aminopeptidase activities in cyclosporin-treated mice
Int. Immunopharmacol.
6
415-425
2006
Mus musculus
Schaeffer, M.; de Miranda, A.; Mottram, J.C.; Coombs, G.H.
Differentiation of Leishmania major is impaired by over-expression of pyroglutamyl peptidase I
Mol. Biochem. Parasitol.
150
318-329
2006
Leishmania major
Kilbane, Z.; Vaas, P.R.; Cuiv, P.O.; OConnor, B.
Cloning and heterologous expression of bovine pyroglutamyl peptidase type-1 in Escherichia coli: purification, biochemical and kinetic characterisation
Mol. Cell. Biochem.
297
189-197
2007
Bos taurus
Zambotti-Villela, L.; Yamasaki, S.C.; Villarroel, J.S.; Murena-Nunes, C.; Silveira, P.F.
Prolyl, cystyl and pyroglutamyl peptidase activities in the hippocampus and hypothalamus of streptozotocin-induced diabetic rats
Peptides
28
1586-1595
2007
Rattus norvegicus
Agirregoitia, N.; Casis, L.; Gil, J.; Ruiz, F.; Irazusta, J.
Ontogeny of prolyl endopeptidase and pyroglutamyl peptidase I in rat tissues
Regul. Pept.
139
52-58
2007
Rattus norvegicus
Marinho, C.; SM, A.; Yamasaki, S.; Silveira, P.
Seasonal variation of peptidase activities in the reproductive tract of Crotalus durissus terrificus
Gen. Comp. Endocrinol.
160
84-92
2009
Crotalus durissus terrificus
Tsunasawa, S.; Nakura, S.; Tanigawa, T.; Kato, I.
Pyrrolidone carboxyl peptidase from the hyperthermophilic archaeon Pyrococcus furiosus: cloning and overexpression in Escherichia coli of the gene, and its application to protein sequence analysis
J. Biochem.
124
778-783
1998
Pyrococcus furiosus (O73944), Pyrococcus furiosus
Sokabe, M.; Kawamura, T.; Sakai, N.; Yao, M.; Watanabe, N.; Tanaka, I.
The X-ray crystal structure of pyrrolidone-carboxylate peptidase from hyperthermophilic archaea Pyrococcus horikoshii
J. Struct. Funct. Genomics
2
145-154
2002
Pyrococcus horikoshii (O58321), Pyrococcus horikoshii, Pyrococcus horikoshii OT-3 (O58321)
Sokol, B.; Hofstad, T.
Enzyme profiles of Clostridium difficile strains isolated from children
Cytobios
66
35-40
1991
Clostridioides difficile
Singleton, M.R.; Taylor, S.J.; Parrat, J.S.; Littlechild, J.A.
Cloning, expression, and characterization of pyrrolidone carboxyl peptidase from the archaeon Thermococcus litoralis
Extremophiles
4
297-303
2000
Thermococcus litoralis (O07883), Thermococcus litoralis, Thermococcus litoralis DSM 5473 (O07883)
Mizuguchi, M.; Takeuchi, M.; Ohki, S.; Nabeshima, Y.; Kouno, T.; Aizawa, T.; Demura, M.; Kawano, K.; Yutani, K.
Structural characterization of a trapped folding intermediate of pyrrolidone carboxyl peptidase from a hyperthermophile
Biochemistry
51
6089-6096
2012
Pyrococcus furiosus (O73944)
Carrera-Gonzalez, M. del P.; Ramirez-Exposito, M.J.; Duenas, B.; Martinez-Ferrol, J.; Mayas, M.D.; Martinez-Martos, J.M.
Putative relationship between hormonal status and serum pyrrolidone carboxypeptidase activity in pre- and post-menopausal women with breast cancer
Breast
21
751-754
2012
Homo sapiens
Megias, M.J.; Alba-Araguez, F.; Luna, J.D.; Vives, F.; Ramirez-Sanchez, M.
Serum pyroglutamyl aminopeptidase activity: apromising novel biomarker candidate for liver cirrhosis
Endocr. Regul.
49
20-24
2015
Homo sapiens
Compton, S.; Kania, S.; Robertson, A.; Lawhon, S.; Jenkins, S.; Westblade, L.; Bemis, D.
Evaluation of pyrrolidonyl arylamidase activity in Staphylococcus delphini
J. Clin. Microbiol.
55
859-864
2017
Enterococcus faecalis, no activity in Staphylococcus aureus, Staphylococcus pseudintermedius, Staphylococcus delphini, no activity in Staphylococcus pseudintermedius, Staphylococcus delphini MI 09-8445, no activity in Staphylococcus aureus ATCC 25923, Staphylococcus pseudintermedius LMG 22219T, Staphylococcus delphini 56-039, Staphylococcus delphini 53-033, Staphylococcus delphini VPP 12 D, Enterococcus faecalis ATCC 29212, Staphylococcus delphini 52-006, Staphylococcus delphini 56-021, Staphylococcus delphini 62-031, Staphylococcus delphini MI 16-1129, no activity in Staphylococcus pseudintermedius LMG 22219T, Staphylococcus delphini MI 09-2894, Staphylococcus delphini 49-046
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