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Literature summary for 3.4.19.3 extracted from
- Prolyl, cystyl and pyroglutamyl peptidase activities in the hippocampus and hypothalamus of streptozotocin-induced diabetic rats (2007), Peptides, 28, 1586-1595.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| glucose | alters the hypothalamic activity of soluble PAP-I | Rattus norvegicus |  |
| Insulin | alters the hypothalamic activity of soluble PAP-I | Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | diabetes mellitus affects the levels of hippocampal and hypothalamic PAP-I activities, which may change the metabolic control of its susceptible physiological peptide substrates in the brain | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amastatin | inhibits soluble PAP-I in the hippocampus by 12.5% and in the hypothalamus by 13.8%. Does not inhibit membrane-bound PAP-I | Rattus norvegicus | |
| bestatin | inhibits soluble PAP-I in the hippocampus by 14.8% and in the hypothalamus by 14.4%. Inhibition of membrane-bound PAP-I in the hypothalamus by 8.8% | Rattus norvegicus | |
| additional information | not inhibited by phenyl methyl sulphonyl fluoride. 28% reduced activity of soluble PAP-I and 40-45% reduced activity of membrane-bound PAP-I in both the hippocampus and hypothalamus of streptozotocin-diabetic rats. Changes can be mitigated by concomitant treatment with insulin | Rattus norvegicus | |
| puromycin | inhibits soluble PAP-I in the hippocampus by 15.5% and in the hypothalamus by 42.5%. Inhibition of membrane-bound PAP-I in the hippcampus by 11.5% | Rattus norvegicus | |
| Zn2+ | inhibits soluble PAP-1 in the hippocampus and hypothalamus, does not inhibit membrane-bound PAP-I | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Rattus norvegicus | 16020 | - |
| soluble | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| hippocampus | - |
Rattus norvegicus | - |
| hypothalamus | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAP-I | - |
Rattus norvegicus |
| pyroglutamyl type I aminopeptidase | - |
Rattus norvegicus |
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