Any feedback?
Literature summary for 3.4.19.3 extracted from
- An evaluation of the role of a pyroglutamyl peptidase, a post-proline cleaving enzyme and a post-proline dipeptidyl amino peptidase, each purified from the soluble fraction of guinea-pig brain, in the degradation of thyroliberin in vitro (1983), Eur. J. Biochem., 137, 75-87.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Cavia porcellus |  |
| 2-Iodoacetamide | - |
Cavia porcellus | |
| 8-hydroxyquinoline | - |
Cavia porcellus | |
| iodoacetamide | - |
Cavia porcellus | |
| NEM | - |
Cavia porcellus | |
| PCMB | - |
Cavia porcellus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.15 | - |
pyroglutamate-4-methylcoumarin 7-amide | - |
Cavia porcellus | |
| 0.727 | - |
Thyroliberin | - |
Cavia porcellus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cavia porcellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Cavia porcellus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acid-thyroliberin + H2O | i.e. pyroglutamyl-His-Pro | Cavia porcellus | pyroglutamate + His-Pro | - |
? | |
| bombesin + H2O | i.e. pyroglutamyl-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 | Cavia porcellus | pyroglutamate + Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 | - |
? | |
| bradykinin-potentiating peptide B + H2O | cleavage of the peptide bond adjacent to the pyroglutamic residue | Cavia porcellus | ? | - |
? | |
| luliberin + H2O | i.e. pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 | Cavia porcellus | pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 | - |
? | |
| neurotensin + H2O | i.e. pyroglutamyl-Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu | Cavia porcellus | pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu | - |
? | |
| pyroglutamyl-4-methylcoumarin 7-amide + H2O | - |
Cavia porcellus | pyroglutamate + 7-amino-4-methylcoumarin | - |
? | |
| pyroglutamyl-Ala + H2O | - |
Cavia porcellus | pyroglutamate + Ala | - |
? | |
| pyroglutamyl-His-Gly + H2O | i.e. anorexogenic peptide | Cavia porcellus | pyroglutamate + His-Gly | - |
? | |
| thyroliberin + H2O | i.e. pyroglutamyl-His-Pro-NH2, i.e. thyrotrophin releasing hormone | Cavia porcellus | pyroglutamate + His-Pro-NH2 | - |
? | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
