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Information on EC 1.14.11.67 - [histone H3]-trimethyl-L-lysine4 demethylase

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IUBMB Comments
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated L-lysine residues at position 4 of histone H3 (H3K4). The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. They can act on tri-, di-, and mono-methylated forms.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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a [histone H3]-N6,N6,N6-trimethyl-L-lysine4
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3
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3
=
a [histone H3]-L-lysine4
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3
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3
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3
Synonyms
amine oxidase flavin-containing domain 1, amine-oxidase flavin-containing domain 1, AOF1, AOF2, At2g34880, BHC110, BHC110/LSD1, demethylase LSD1, Fbxl10, H3K4 demethylase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
a [histone H3]-N6,N6,N6-trimethyl-L-lysine4 + 3 2-oxoglutarate + 3 O2 = a [histone H3]-L-lysine4 + 3 succinate + 3 formaldehyde + 3 CO2
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overall reaction
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a [histone H3]-N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine4 + succinate + formaldehyde + CO2
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(1a); (1b)
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a [histone H3]-N6-methyl-L-lysine4 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine4 + succinate + formaldehyde + CO2
show the reaction diagram
(1c)
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