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BRENDA support

Ligand succinic acid

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Basic Ligand Information

Molecular Structure
Picture of succinic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H6O4
succinic acid
KDYFGRWQOYBRFD-UHFFFAOYSA-N
Synonyms:
a dicarboxylate, butanedioic acid, dihydrofumarate, reduced fumarate, succinate, succinate buffer
Pathway Source
Pathways
BRENDA
(5R)-carbapenem carboxylate biosynthesis, 3-phenylpropionate degradation, 4-hydroxymandelate degradation, aerobic toluene degradation, arginine metabolism more
KEGG
Alanine, aspartate and glutamate metabolism, Biosynthesis of alkaloids derived from histidine and purine, Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid, Biosynthesis of alkaloids derived from shikimate pathway, Biosynthesis of alkaloids derived from terpenoid and polyketide more
MetaCyc
(-)-4'-demethyl-epipodophyllotoxin biosynthesis, (2-trimethylamino)ethylphosphonate degradation, (3R)-N-[(2S)-1-hydroxy-6-[(3R)-3-isocyanobutanamido]hexan-2-yl]-3-isocyanobutanamide biosynthesis, (5R)-carbapenem carboxylate biosynthesis, (Kdo)2-lipid A biosynthesis (P. putida) more


Show all pahtways known for Show all BRENDA pathways known for succinic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (35 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
propionyl-CoA + succinate = propanoate + succinoyl-CoA
show the reaction diagram
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succinate + (S)-(+)-citramalyl-CoA = succinyl-CoA + citramalate
show the reaction diagram
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propanoyl-CoA + succinate = propanoate + succinyl-CoA
show the reaction diagram
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succinate + menaquinone + 2 H+[side 1] = fumarate + menaquinol + 2 H+[side 2]
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (379 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3 2-oxoglutarate + L-arginine + 3 O2 = 2 C2H4 + succinate + 7 CO2 + 3 H2O + guanidine + L-DELTA1-pyrroline-5-carboxylate
show the reaction diagram
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4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2
show the reaction diagram
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2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + deoxyribonolactone + succinate + CO2
show the reaction diagram
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gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2
show the reaction diagram
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taurine + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2
show the reaction diagram
phytanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyphytanoyl-CoA + succinate + CO2
show the reaction diagram
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deacetoxyvindoline + 2-oxoglutarate + O2 = deacetylvindoline + succinate + CO2
show the reaction diagram
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L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2
show the reaction diagram
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hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O2 = hypoxia-inducible factor-(3S)-3-hydroxy-L-asparagine + succinate + CO2
show the reaction diagram
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kanamycin B + 2-oxoglutarate + O2 = 2'-dehydrokanamycin A + succinate + NH3 + CO2
show the reaction diagram
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fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2 = verruculogen + succinate + CO2 + H2O + A
show the reaction diagram
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L-asparagine + 2-oxoglutarate + O2 = (2S,3S)-3-hydroxyasparagine + succinate + CO2
show the reaction diagram
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L-enduracididine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-enduracididine + succinate + CO2
show the reaction diagram
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7-(3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + 2-oxoglutarate + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + succinate + CO2
show the reaction diagram
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(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (2-amino-1-hydroxyethyl)phosphonate + succinate + CO2
show the reaction diagram
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[50S ribosomal protein L16]-L-Arg81 + 2-oxoglutarate + O2 = [50S ribosomal protein L16]-(3R)-3-hydroxy-L-Arg81 + succinate + CO2
show the reaction diagram
xanthine + 2-oxoglutarate + O2 = urate + succinate + CO2
show the reaction diagram
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UMP + 2-oxoglutarate + O2 = 5'-dehydrouridine + succinate + CO2 + phosphate
show the reaction diagram
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N6-methyladenine in DNA + 2-oxoglutarate + O2 = adenine in DNA + formaldehyde + succinate + CO2
show the reaction diagram
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validamycin A + 2-oxoglutarate + O2 = validamycin B + succinate + CO2
show the reaction diagram
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L-proline + 2-oxoglutarate + O2 = trans-4-hydroxy-L-proline + succinate + CO2
show the reaction diagram
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scopoletin + 2-oxoglutarate + O2 = fraxetin + succinate + CO2
show the reaction diagram
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trans-feruloyl-CoA + 2-oxoglutarate + O2 = trans-6-hydroxyferuloyl-CoA + succinate + CO2
show the reaction diagram
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a [protein]-L-lysine + 2-oxoglutarate + O2 = a [protein]-(3S)-3-hydroxy-L-lysine + succinate + CO2
show the reaction diagram
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methylphosphonate + 2-oxoglutarate + O2 = hydroxymethylphosphonate + succinate + CO2
show the reaction diagram
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[2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2
show the reaction diagram
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L-isoleucine + 2-oxoglutarate + O2 = (3S)-3'-hydroxy-L-isoleucine + succinate + CO2
show the reaction diagram
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(3S)-3'-hydroxy-L-isoleucine + 2-oxoglutarate + O2 = (3S,4R)-3',4-dihydroxy-L-isoleucine + succinate + CO2
show the reaction diagram
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S-(L-glutamyl)-[peptidyl-carrier protein of nonribosomal peptide synthetase KtzH] + 2-oxoglutarate + O2 = S-(erythro-3-hydroxy-L-glutamyl)-[peptidyl-carrier-protein of nonribosomal peptide synthetase KtzH] + succinate + CO2
show the reaction diagram
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S-(L-glutamyl)-[peptidyl-carrier protein of nonribosomal peptide synthetase KtzH] + 2-oxoglutarate + O2 = S-(threo-3-hydroxy-L-glutamyl)-[peptidyl-carrier-protein of nonribosomal peptide synthetase KtzH] + succinate + CO2
show the reaction diagram
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(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = 3-[(Z)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O
show the reaction diagram
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(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = 3-[(E)-2-isocyanoethenyl]-1H-indole + succinate + 2 CO2 + H2O
show the reaction diagram
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L-threonyl-[L-threonyl-carrier protein SyrB1] + 2-oxoglutarate + O2 + Cl- = 4-chloro-L-threonyl-[L-threonyl-carrier protein SyrB1] + succinate + CO2 + H2O
show the reaction diagram
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2R,3S,4S-cis-leucoanthocyanidin + 2-oxoglutarate + O2 = cis- and trans-dihydroquercetins + succinate + CO2 + 2 H2O
show the reaction diagram
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(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + succinate + CO2 + H2O
show the reaction diagram
(2S)-3-(4-hydroxyphenyl)-2-isocyanopropanoate + 2-oxoglutarate + O2 = (2E)-3-(4-hydroxyphenyl)-2-isocyanoprop-2-enoate + succinate + CO2 + H2O
show the reaction diagram
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succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+
show the reaction diagram
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fumarate + CoM + CoB = succinate + CoM-S-S-CoB
show the reaction diagram
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succinyl-CoA + 3-hydroxy-3-methylglutarate = succinate + 3-hydroxy-3-methylglutaryl-CoA
show the reaction diagram
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succinyl-CoA + (R)-2-benzylsuccinate = succinate + (R)-2-benzylsuccinyl-CoA
show the reaction diagram
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succinyl-CoA + acetate = acetyl-CoA + succinate
show the reaction diagram
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succinyl-CoA + oxalate = succinate + oxalyl-CoA
show the reaction diagram
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succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA
show the reaction diagram
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succinyl-CoA + (S)-malate = succinate + (S)-malyl-CoA
show the reaction diagram
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mesaconate + succinyl-CoA = 2-methylfumaryl-CoA + succinate
show the reaction diagram
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succinamic acid + H2O = succinic acid + NH3
show the reaction diagram
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succinonitrile + 2 H2O = succinic acid + NH3
show the reaction diagram
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fumarate + menaquinol + 2 H+[side 2] = succinate + menaquinone + 2 H+[side 1]
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (120 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
succinate + NAD(P)+ = succinic acid anhydride + NAD(P)H
show the reaction diagram
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succinate + 2,6-dichlorophenolindophenol = ?
show the reaction diagram
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succinate + O2 = ?
show the reaction diagram
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(6S)-hydroxyhyoscyamine + succinate + CO2 = L-hyoscyamine + 2-oxoglutarate + O2
show the reaction diagram
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methane + succinate + O2 = methanol + fumarate + H2O
show the reaction diagram
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succinate + NADH = succinic semialdehyde + NAD+ + H2O
show the reaction diagram
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succinate + acetyl-CoA = acetate + succinyl-CoA
show the reaction diagram
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1,4-cyclohexanedimethanol + succinic acid = ?
show the reaction diagram
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succinate = ?
show the reaction diagram
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Dihydrofumarate = Tartronate semialdehyde + CO2
show the reaction diagram
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ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
show the reaction diagram
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ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
show the reaction diagram
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ATP + succinate + CoA = ADP + phosphate + succinyl-CoA
show the reaction diagram
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ATP + succinate + (2S)-2,3-diaminopropionate = ?
show the reaction diagram
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succinate + menaquinone + 2 H+[side 1] = fumarate + menaquinol + 2 H+[side 2]
show the reaction diagram
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succinate + O2 + NAD+ = NADH + ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1142 results)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
H2 + fumarate = succinate
show the reaction diagram
-
3 2-oxoglutarate + L-arginine + 3 O2 = 2 C2H4 + succinate + 7 CO2 + 3 H2O + guanidine + L-DELTA1-pyrroline-5-carboxylate
show the reaction diagram
-
gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2
show the reaction diagram
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(+/-)-1-deoxypentalenic acid + O2 = 11beta-hydroxy-1-deoxypentalenic acid + succinate + CO2
show the reaction diagram
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pentalenolactone D + 2 2-oxoglutarate = pentalenolactone F + 2 succinate + 2 CO2 + H2O
show the reaction diagram
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kanamycin B + 2-oxoglutarate + O2 = 2'-dehydrokanamycin A + succinate + NH3 + CO2
show the reaction diagram
-
fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2 = verruculogen + succinate + CO2 + H2O + A
show the reaction diagram
-
L-asparagine + 2-oxoglutarate + O2 = (2S,3S)-3-hydroxyasparagine + succinate + CO2
show the reaction diagram
-
L-enduracididine + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-enduracididine + succinate + CO2
show the reaction diagram
-
7-(3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + 2-oxoglutarate + O2 = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine37 in tRNAPhe + succinate + CO2
show the reaction diagram
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(2-aminoethyl)phosphonate + 2-oxoglutarate + O2 = (2-amino-1-hydroxyethyl)phosphonate + succinate + CO2
show the reaction diagram
-
xanthine + 2-oxoglutarate + O2 = urate + succinate + CO2
show the reaction diagram
-
UMP + 2-oxoglutarate + O2 = 5'-dehydrouridine + succinate + CO2 + phosphate
show the reaction diagram
-
N6-methyladenine in DNA + 2-oxoglutarate + O2 = adenine in DNA + formaldehyde + succinate + CO2
show the reaction diagram
-
validamycin A + 2-oxoglutarate + O2 = validamycin B + succinate + CO2
show the reaction diagram
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L-proline + 2-oxoglutarate + O2 = trans-4-hydroxy-L-proline + succinate + CO2
show the reaction diagram
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an ornithine lipid + 2-oxoglutarate + O2 = a 2-hydroxyornithine lipid + succinate + CO2
show the reaction diagram
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(2R)-4-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside + 2-oxoglutarate + O2 = (2R)-4,7-dihydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl beta-D-glucopyranoside + succinate + CO2 + H2O
show the reaction diagram
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