Ligand 2-oxoglutaric acid

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Basic Ligand Information

Molecular Structure
Picture of 2-oxoglutaric acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H6O5
2-oxoglutaric acid
KPGXRSRHYNQIFN-UHFFFAOYSA-N
Synonyms:
2-Ketoglutarate, 2-ketoglutaric acid, 2-oxo-1,5-pentandioate, 2-oxo-1,5-pentanedioate, 2-oxo-glutarate, 2-oxoglutamate, 2-oxoglutarate, 2-oxoglutarate (charged), 2-oxopentanedioate, 2-oxopentanedioic acid, 2-[3,3,4,4-(2)H(4)]ketoglutarate, alpha-keto-glutarate, alpha-ketoglutarate, alpha-Ketoglutaric acid, alpha ketoglutarate, ketoglutarate, L-2-oxoglutarate, oxoglutarate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1386 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-oxoglutarate + NAD+ = D-2-hydroxyglutaric acid + NADH + H+
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2-oxoglutarate + NADH + H+ = (R)-2-hydroxyglutarate + NAD+
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2-oxoglutarate + NADH + H+ = D-2-hydroxyglutarate + NAD+
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4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2
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2'-deoxyuridine + 2-oxoglutarate + O2 = uracil + deoxyribonolactone + succinate + CO2
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gibberellin 44 + 2-oxoglutarate + O2 = gibberellin 19 + succinate + CO2
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phytanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyphytanoyl-CoA + succinate + CO2
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deacetoxyvindoline + 2-oxoglutarate + O2 = deacetylvindoline + succinate + CO2
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L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2
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neopentalenolactone D + 2 2-oxoglutarate = neopentalenolactone F + methyl (1R,6aR)-6a-acetyl-1-(2-methoxy-2-oxoethyl)-5,5-dimethyl-1,3a,4,5,6,6a-hexahydropentalene-2-carboxylate + ?
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kanamycin B + 2-oxoglutarate + O2 = 2'-dehydrokanamycin A + succinate + NH3 + CO2
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fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2 = verruculogen + succinate + CO2 + H2O + A
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L-asparagine + 2-oxoglutarate + O2 = (2S,3S)-3-hydroxyasparagine + succinate + CO2
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