Literature summary for 1.14.11.67 extracted from

Xu, L.; Wu, H.; Hu, X.
Histone demethylase KDM5A enhances cell proliferation, induces EMT in lung adenocarcinoma cells, and have a strong causal association with paclitaxel resistance (2021), Acta Biochim. Pol., 68, 593-602 .

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Application

Application	Comment	Organism
medicine	paclitaxel-resistant lung adenocarcinoma PTX-Calu-3 cells show significantly higher IC50 value (7 microM) upon paclitaxel treatxadment than lung adenocarcinoma SK-LI-1 (3.6 nM), Calu-3 (4.3 nM), and A549 (4.5 nM) cells. Expression of KDM5A and P-glycoprotein are significantly higher in PTX-Calu-3 cells compared to SK-LI-1, Calu-3, and A549 cells. A significantly higher number of PTX-Calu-3 cells are inxadvasive and motile compared to SK-LI-1, Calu-3, and A549 cells. A significantly higher expression of KDM5A is observed in lung adenocarcixadnoma patients' samples compared with adjacent normal tissues as well as in PTX-Calu-3 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P29375	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
Calu-3 cell	-	Homo sapiens	-
PTX-Calu-3 cell	-	Homo sapiens	-
SK-LI-1 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)