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Literature summary for 1.14.11.67 extracted from

  • Li, Q.M.; Li, J.L.; Feng, Z.H.; Lin, H.C.; Xu, Q.
    Effect of histone demethylase KDM5A on the odontogenic differentiation of human dental pulp cells (2020), Bioengineered, 11, 449-462 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens P29375
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Source Tissue

Source Tissue Comment Organism Textmining
dental pulp
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 Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens KDM5A demonstrates significantly enhanced expression during cytodifferentiation of dental pulp cells. KDM5A expression increases during early passages and in a time-dependent manner during odontogenic induction up

General Information

General Information Comment Organism
physiological function in dental pulp cells, KDM5A depletion results in greater alkaline phosphatase activity and more mineral deposition formation. The expression levels of the odontogenic markers DMP1, DSPP, OSX, and OCN are increased by KDM5A knockdown. KDM5A deficiency leads to a significant increment in total H3K4me3 levels, whereas no significant difference is found for H3K4 me2. H3K4me3 levels on the promoters of the odontogenic markers increase after KDM5A knockdown in dental pulp cells Homo sapiens