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Literature summary for 1.14.11.67 extracted from

  • Zhao, B.; Liang, Q.; Ren, H.; Zhang, X.; Wu, Y.; Zhang, K.; Ma, L.; Zheng, Y.; Liu, H.
    Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B) (2020), Eur. J. Med. Chem., 192, 112161 .
    View publication on PubMed
Search for more literature for 1.14.11.67

Inhibitors

Inhibitors Comment Organism Structure
(3-phenyl-1-(p-tolyl)-1H-pyrazol-4-yl)(4-(2-(pyrrolidin-1-yl) ethyl)piperazin-1-yl) methanone
-
 Homo sapiens
1-(2-methoxyphenyl)-N-(2-methyl-2-morpholinopropyl)-3-phenyl-1H-pyrazole-4-carboxamide
-
 Homo sapiens
1-(4-methoxyphenyl)-N-(2-methyl-2-morpholinopropyl)-3-phenyl-1H-pyrazole-4-carboxamide compound is a cellular active KDM5B inhibitor that can inhibit MKN45 cell proliferation, wound healing and migration. The compound can bind and stabilize KDM5B and induce the accumulation of H3K4me2/3 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UGL1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MKN-45 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
KDM5B
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000024
-
 pH 7.5, temperature not specified in the publication Homo sapiens 1-(4-methoxyphenyl)-N-(2-methyl-2-morpholinopropyl)-3-phenyl-1H-pyrazole-4-carboxamide
0.000073
-
 pH 7.5, temperature not specified in the publication Homo sapiens (3-phenyl-1-(p-tolyl)-1H-pyrazol-4-yl)(4-(2-(pyrrolidin-1-yl) ethyl)piperazin-1-yl) methanone
0.000093
-
 pH 7.5, temperature not specified in the publication Homo sapiens 1-(2-methoxyphenyl)-N-(2-methyl-2-morpholinopropyl)-3-phenyl-1H-pyrazole-4-carboxamide