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EC Explorer

EC 2.3.1.237 Details
EC number
2.3.1.237
Accepted name
neocarzinostatin naphthoate synthase
Reaction
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ = 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
Other name(s)
naphthoic acid synthase, NNS, ncsB (gene name)
Systematic name
malonyl-CoA:acetyl-CoA malonyltransferase (2-hydroxy-5-methyl-1-naphthoic acid-forming)
Comment
A multi-domain polyketide synthase involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
History
created 2014
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992