Any feedback?
Please rate this page
(ecexplorer.php)
(0/150)

BRENDA support

EC Explorer

EC 2.3.1.299 Details
EC number
2.3.1.299
Accepted name
sphingoid base N-stearoyltransferase
Reaction
stearoyl-CoA + a sphingoid base = an N-(stearoyl)-sphingoid base + CoA
Other name(s)
mammalian ceramide synthase 1, LASS1 (gene name), UOG1 (gene name), CERS1 (gene name)
Systematic name
stearoyl-CoA:sphingoid base N-stearoyltransferase
Comment
Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates. Ceramide synthase 1 (CERS1) is structurally and functionally distinctive from all other CERS enzymes, and is specific for stearoyl-CoA as the acyl donor. It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.
History
created 2019
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992