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EC 2.3.1.162 Details
EC number
2.3.1.162
Accepted name
taxadien-5α-ol O-acetyltransferase
Reaction
acetyl-CoA + taxa-4(20),11-dien-5α-ol = CoA + taxa-4(20),11-dien-5α-yl acetate
Other name(s)
acetyl coenzyme A:taxa-4(20),11(12)-dien-5α-ol O-acetyl transferase
Systematic name
acetyl-CoA:taxa-4(20),11-dien-5α-ol O-acetyltransferase
CAS registry number
229032-29-5
Comment
This is the third enzyme in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel), which is widely used in the treatment of carcinomas, sarcomas and melanomas.
History
created 2002
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992