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Information on EC 2.3.1.162 - taxadien-5alpha-ol O-acetyltransferase

for references in articles please use BRENDA:EC2.3.1.162
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IUBMB Comments
This is the third enzyme in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel), which is widely used in the treatment of carcinomas, sarcomas and melanomas.
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The expected taxonomic range for this enzyme is: Taxus
Synonyms
tmtat, taxadienol acetyl transferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate
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