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EC 2.3.1.97 Details
EC number
2.3.1.97
Accepted name
glycylpeptide N-tetradecanoyltransferase
Reaction
tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Other name(s)
NMT (gene name), peptide N-myristoyltransferase, myristoyl-CoA-protein N-myristoyltransferase, myristoyl-coenzyme A:protein N-myristoyl transferase, myristoylating enzymes, protein N-myristoyltransferase, tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase
Systematic name
tetradecanoyl-CoA:N-terminal-glycine-[protein] N-tetradecanoyltransferase
CAS registry number
110071-61-9
Comment
The enzyme catalyses the transfer of myristic acid from myristoyl-CoA to the amino group of the N-terminal glycine residue in a variety of eukaryotic proteins. It uses an ordered Bi Bi reaction in which myristoyl-CoA binds to the enzyme prior to the binding of the peptide substrate, and CoA release precedes the release of the myristoylated peptide. The enzyme from yeast is profoundly affected by amino acids further from the N-terminus, and is particularly stimulated by a serine residue at position 5.
History
created 1989, modified 1990, modified 2018
EC Tree
2.3.1.55 created 1976, deleted 1999
2.3.1.120 created 1990, deleted 1992
2.3.1.124 created 1990, deleted 1992