Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

7.2.2.1: Na+-transporting two-sector ATPase

This is an abbreviated version!
For detailed information about Na+-transporting two-sector ATPase, go to the full flat file.

Word Map on EC 7.2.2.1

Reaction

ATP
+
H2O
 + n Na+[side 1] =
ADP
 +
phosphate
 + n Na+[side 2]

Synonyms

A1AO ATP synthase, ATP phosphohydrolase (Na+-transporting), ATP synthase, EC 3.6.3.15, F-type ATP synthase, F1FO-ATPase, KPA1, Lipid-binding protein, Na+ pump, Na+ V-ATPase, Na+(Li+, K+)/H+ antiporter, Na+-ATPase, Na+-translocating ATPase, Na+-translocating F1FO-ATPase, Na+-translocating V-ATPase, Na+-transporting FoF1 ATP synthase, Na+-transporting P-type ATPase, Na+-transporting two-sector ATPase, Na+-transporting V-ATPase, Ntp, sodium ion-pumping adenosine triphosphatase, UmpAB, V-ATPase, V-type Na+-ATPase, vacuolar Na+-translocating ATPase, vacuolar-type Na+-ATPase, vacuolar-type Na+-translocating ATPase, vacuole-type ATPase

ECTree

     7 Translocases
         7.2 Catalysing the translocation of inorganic cations
             7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
                7.2.2.1 Na+-transporting two-sector ATPase

Inhibitors

Inhibitors on EC 7.2.2.1 - Na+-transporting two-sector ATPase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5-(N,N-hexamethylene)-amiloride
-
-
5-(N,N-Hexamethylene)amiloride
-
70% inhibition at 0.1 mM, Na+ protects against inactivation
5-(N-ethyl-N-isopropyl)-amiloride
-
-
5-(N-ethyl-N-isopropyl)amiloride
-
70% inhibition at 0.1 mM, Na+ protects against inactivation
7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole
-
-
ATPgammaS
-
inhibits ATPase activity but not the Na+ binding capacity of the enzyme
azide
Carbonyl cyanide m-chlorophenylhydrazone
-
0.02 mM, pH 9.0, 75% inhibition with no or low levels of NaCl
destruxin B
dienestrol
-
-
diethylstilbestrol
Furosemide
-
-
H+
-
competitively inhibits binding of Na+ to the K-ring of the enzyme, binding structure, overview
Hexestrol
-
-
Li+
-
competitively inhibits binding of Na+ to the K-ring of the enzyme, binding structure, overview
N',N'-dicyclohexylcarbodiimide
-
inhibition can be relieved by Na+
N,N'-dicyclohexyl-carbodiimide
-
half maximal inhibition at 0.1 mM. N,N'-dicyclohexyl-carbodiimide and Na+ compete for binding to subunit c
N,N'-dicyclohexylcarbodiimide
N,N,N',N'-tetracyclohexyl-1,2-phenylenedioxydiacetamide
-
i.e. ETH 2120, complete inhibition. Addition of ETH 2120 to the assay during active transport of Na+ immediately stops further Na+ translocation into the lumen of the proteoliposomes
N-10-benzylamiloride
N-ethylmaleimide
-
inhibition of ATPase activity
orthovanadate
-
0.3 mM
tetraphenylboron
-
complete inhibition of ATP-dependent Na+ uptake
tributyltin
-
85% inhibition at 0.001 mM
valinomycin
-
-
vanadate
Venturicidin
-
inhibition of both ATPase and Na+ translocation activities
additional information
-