7.2.2.1: Na+-transporting two-sector ATPase

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For detailed information about Na+-transporting two-sector ATPase, go to the full flat file.

Word Map on EC 7.2.2.1

7.2.2.1

ouabain

electrogenic

k+-atpase

depolarization

ouabain-sensitive

basolateral

hyperpolarization

na+,k+-atpase

transepithelial

amiloride

na+-dependent

k+-free

microelectrodes

na+-pumping

hirae

rb+

sarcolemmal

na+-stimulated

short-circuit

alginolyticus

na+-k+-adenosinetriphosphatase

3h-ouabain

low-na+

digitalis-like

ouabain-inhibitable

ouabain-induced

dccd

na+-sensitive

nadh:quinone

strophanthidin

isophthalate

na+-loaded

countertransport

Reaction

+ n Na+[side 1] =

+ n Na+[side 2]

Synonyms

A1AO ATP synthase, ATP phosphohydrolase (Na+-transporting), ATP synthase, EC 3.6.3.15, F-type ATP synthase, F1FO-ATPase, KPA1, Lipid-binding protein, Na+ pump, Na+ V-ATPase, Na+(Li+, K+)/H+ antiporter, Na+-ATPase, Na+-translocating ATPase, Na+-translocating F1FO-ATPase, Na+-translocating V-ATPase, Na+-transporting FoF1 ATP synthase, Na+-transporting P-type ATPase, Na+-transporting two-sector ATPase, Na+-transporting V-ATPase, Ntp, sodium ion-pumping adenosine triphosphatase, UmpAB, V-ATPase, V-type Na+-ATPase, vacuolar Na+-translocating ATPase, vacuolar-type Na+-ATPase, vacuolar-type Na+-translocating ATPase, vacuole-type ATPase

ECTree

7 Translocases

7.2 Catalysing the translocation of inorganic cations

7.2.2 Linked to the hydrolysis of a nucleoside triphosphate

7.2.2.1 Na+-transporting two-sector ATPase

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Results	in table
6	Activating Compound
321	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
2	Cofactor
1	Crystallization (Commentary)
1	Expression
1	General Stability
3	IC50 Value
64	Inhibitors
3	Ki Value [mM]
16	KM Value [mM]
22	Localization
44	Metals/Ions
86	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
60	Organism
27	PDB ID
14	pH Optimum
2	pH Range
3	Posttranslational Modification
18	Protein Variants
14	Purification (Commentary)
1	Reaction
9	Reaction Type
45	Reference
2	Source Tissue
9	Specific Activity [micromol/min/mg]
5	Storage Stability
67	Substrates and Products (Substrate)
25	Subunits
71	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
2	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 7.2.2.1 - Na+-transporting two-sector ATPase

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ATP + H2O

ADP + phosphate

Caloramator fervidus

Q2EQR4, Q2EQR5, Q2EQR6, Q2EQR7, Q2EQR8, Q2EQR9, Q2EQS0, Q2EQS1, Q2EQS2

the V-type ATPase pumps Na+ ions out of the cell against the sodium ion motive force at the expense of the hydrolysis of ATP. The enzyme complex consists of an integral membrane part V0 that is responsible for the translocation of the Na+ ions and a cytoplasmic, membrane associated part V1 that hydrolyzes ATP, it functions as two coupled molecular motors

684748

ATP + H2O + n Na+[side 1]

ADP + phosphate + n Na+[side 2]

3 entries

ATP + H2O + Na+/in

ADP + phosphate + Na+/out

6 entries

ATP + H2O + Na/+in

ADP + phosphate + Na/+out

Sus scrofa

724130

additional information

2 entries