7.2.2.1: Na+-transporting two-sector ATPase
This is an abbreviated version!
For detailed information about Na+-transporting two-sector ATPase, go to the full flat file.
Word Map on EC 7.2.2.1
-
7.2.2.1
-
ouabain
-
electrogenic
-
k+-atpase
-
depolarization
-
ouabain-sensitive
-
basolateral
-
hyperpolarization
-
na+,k+-atpase
-
transepithelial
-
amiloride
-
na+-dependent
-
k+-free
-
microelectrodes
-
na+-pumping
-
hirae
-
rb+
-
sarcolemmal
-
na+-stimulated
-
short-circuit
-
alginolyticus
-
na+-k+-adenosinetriphosphatase
-
3h-ouabain
-
low-na+
-
digitalis-like
-
ouabain-inhibitable
-
ouabain-induced
-
dccd
-
na+-sensitive
-
nadh:quinone
-
strophanthidin
-
isophthalate
-
na+-loaded
-
countertransport
- 7.2.2.1
- ouabain
-
electrogenic
-
k+-atpase
-
depolarization
-
ouabain-sensitive
-
basolateral
-
hyperpolarization
- na+,k+-atpase
-
transepithelial
- amiloride
-
na+-dependent
-
k+-free
-
microelectrodes
-
na+-pumping
- hirae
- rb+
-
sarcolemmal
-
na+-stimulated
-
short-circuit
- alginolyticus
-
na+-k+-adenosinetriphosphatase
-
3h-ouabain
-
low-na+
-
digitalis-like
-
ouabain-inhibitable
-
ouabain-induced
- dccd
-
na+-sensitive
-
nadh:quinone
- strophanthidin
- isophthalate
-
na+-loaded
-
countertransport
Reaction
Synonyms
A1AO ATP synthase, ATP phosphohydrolase (Na+-transporting), ATP synthase, EC 3.6.3.15, F-type ATP synthase, F1FO-ATPase, KPA1, Lipid-binding protein, Na+ pump, Na+ V-ATPase, Na+(Li+, K+)/H+ antiporter, Na+-ATPase, Na+-translocating ATPase, Na+-translocating F1FO-ATPase, Na+-translocating V-ATPase, Na+-transporting FoF1 ATP synthase, Na+-transporting P-type ATPase, Na+-transporting two-sector ATPase, Na+-transporting V-ATPase, Ntp, sodium ion-pumping adenosine triphosphatase, UmpAB, V-ATPase, V-type Na+-ATPase, vacuolar Na+-translocating ATPase, vacuolar-type Na+-ATPase, vacuolar-type Na+-translocating ATPase, vacuole-type ATPase
ECTree
7.2.2.1 Na+-transporting two-sector ATPaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 7.2.2.1 - Na+-transporting two-sector ATPase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + Li+/in
ADP + phosphate + Li+/out
-
coupled to Li+ translocation across the cytoplasmic membrane
-
-
?
CDP + phosphate + Na+/out
CTP + H2O + Na+/in
-
lower activity compared to ADP
-
-
r
CTP + H2O + Na+/in
CDP + phosphate + Na+/out
-
CTP is hydrolyzed at 14% compared to hydrolysis of ATP
-
-
?
GDP + phosphate + Na+/out
GTP + H2O + Na+/in
-
lower activity compared to ADP
-
-
r
GTP + H2O + Na+/in
GDP + phosphate + Na+/out
-
GTP is hydrolyzed at 64% compared to hydrolysis of ATP
-
-
?
IDP + phosphate + Na+/out
ITP + H2O + Na+/in
-
lower activity compared to ADP
-
-
r
ITP + H2O + Na+/in
IDP + phosphate + Na+/out
-
ITP is hydrolyzed at 99% compared to hydrolysis of ATP
-
-
?
UDP + phosphate + Na+/out
UTP + H2O + Na+/in
-
lower activity compared to ADP
-
-
r
UTP + H2O + Na+/in
UDP + phosphate + Na+/out
-
UTP is hydrolyzed at 31% compared to hydrolysis of ATP
-
-
?
ADP + phosphate
ATP
-
Na+-translocating ATPase can work in the synthase mode under alkaline conditions
-
-
r
ADP + phosphate
ATP
-
Na+-translocating ATPase can work in the synthase mode under alkaline conditions
-
-
r
ATP + H2O
ADP + phosphate
-
-
-
ir
ATP + H2O
ADP + phosphate
the V-type ATPase pumps Na+ ions out of the cell against the sodium ion motive force at the expense of the hydrolysis of ATP. The enzyme complex consists of an integral membrane part V0 that is responsible for the translocation of the Na+ ions and a cytoplasmic, membrane associated part V1 that hydrolyzes ATP, it functions as two coupled molecular motors
-
-
ir
ATP + H2O
ADP + phosphate
-
nucleotides are hydrolyzed in the order of decreasing activity: GTP, CTP, UTP, ATP
-
-
?
ATP + H2O
ADP + phosphate
-
Na+-translocating ATPase can work in the synthase mode under alkaline conditions
-
-
r
ATP + H2O
ADP + phosphate
-
Na+-translocating ATPase can work in the synthase mode under alkaline conditions
-
-
r
ATP + H2O + n K+[side 1]
ADP + phosphate + n K+[side 2]
Halomonas zhaodongensis NEAU-ST10-25T
-
-
-
-
?
ATP + H2O + n Li+[side 1]
ADP + phosphate + n Li+[side 2]
Halomonas zhaodongensis NEAU-ST10-25T
-
-
-
-
?
ATP + H2O + n Na+[side 1]
ADP + phosphate + n Na+[side 2]
Halomonas zhaodongensis NEAU-ST10-25T
-
-
-
-
?
ATP + H2O + Na+/in
ADP + phosphate + Na+/out
-
coupled to Na+ translocation across the cytoplasmic membrane
-
-
?
ATP + H2O + Na+/in
ADP + phosphate + Na+/out
-
the purified rotor ring, i.e. K-ring, of the V-ATPase binds one Na+ ion per K-monomer with high affinity. Interaction with the stator subunit, i.e. I-subunit, is essential for Na binding to or release from the K-ring, respectively, ion translocation model, overview
-
-
?
ATP + H2O + Na+/in
ADP + phosphate + Na+/out
-
ATP hydrolysis is strictly dependent on Na+, with a Km of 0.6 mM. Li+, but not K+, can substitute for Na+. The Na+ dependence is less pronounced at higher proton concentrations, indicating competition between Na+ and H+ for a common binding site
-
-
?
ATP + H2O + Na+/in
ADP + phosphate + Na+/out
-
the enzyme reconstituted in proteoliposomes, generated from Escherichia coli lipids, catalyzes ATP-driven Na+ transport
-
-
?
CTP + H2O
CDP + H2O
-
nucleotides are hydrolyzed in the order of decreasing activity: GTP, CTP, UTP, ATP
-
-
?
GTP + H2O
GDP + phosphate
-
hydrolyzed at 31% of the activity with ATP
-
-
?
GTP + H2O
GDP + phosphate
-
Na+-translocating activity, GTP is hydrolyzed as the best substrate
-
-
?
UTP + H2O
UDP + H2O
-
nucleotides are hydrolyzed in the order of decreasing activity: GTP, CTP, UTP, ATP
-
-
?
additional information
?
-
-
the length of the C-terminus as well as specific residues located in the cytoplasmic membrane are important for Na+ transport
-
-
?
additional information
?
-
-
Glu139 of the NtpK proteolipid subunit is binding site of Na+ or Li+ for translocation
-
-
?
additional information
?
-
-
the transcription of the Na+-ATPase operon is regulated by the intracellular concentration of Na+
-
-
?
additional information
?
-
-
enzyme is induced when cells are grown on media rich in sodium
-
-
?
additional information
?
-
-
K+, Tl+, Rb+, and Cs+ cannot substitute Na+
-
-
?
additional information
?
-
-
Na+-translocation involves a minimum of four steps: 1. binding of Na+ from a defined surface of the membrane, translocation of the binary complex to the outer surface, 3. release of Na+, 4. return of the unloaded carrier to the original surface
-
-
?
additional information
?
-
-
neither ADP nor diphosphate are hydrolyzed
-
-
?
