Information on EC 7.2.2.1 - Na+-transporting two-sector ATPase

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IUBMB Comments
A multisubunit ATPase transporter found in some halophilic or alkalophilic bacteria that functions in maintaining sodium homeostasis. The enzyme is similar to EC 7.1.2.2 (H+-transporting two-sector ATPase) but pumps Na+ rather than H+. By analogy to EC 7.1.2.2, it is likely that the enzyme pumps 4 sodium ions for every ATP molecule that is hydrolysed. cf. EC 7.2.2.3, P-type Na+ transporter and EC 7.2.2.4, ABC-type Na+ transporter.
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Word Map
  • 7.2.2.1
  • ouabain
  • electrogenic
  • k+-atpase
  • depolarization
  • ouabain-sensitive
  • basolateral
  • hyperpolarization
  • na+,k+-atpase
  • transepithelial
  • amiloride
  • na+-dependent
  • k+-free
  • microelectrodes
  • na+-pumping
  • hirae
  • rb+
  • sarcolemmal
  • na+-stimulated
  • short-circuit
  • alginolyticus
  • na+-k+-adenosinetriphosphatase
  • 3h-ouabain
  • low-na+
  • digitalis-like
  • ouabain-inhibitable
  • ouabain-induced
  • dccd
  • na+-sensitive
  • nadh:quinone
  • strophanthidin
  • isophthalate
  • na+-loaded
  • countertransport
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
na+ pump, na+-atpase, f-type atp synthase, umpab, na+-translocating atpase, v-type na+-atpase, vacuolar-type na+-translocating atpase, na+-transporting p-type atpase, sodium ion-pumping adenosine triphosphatase, na+-translocating v-atpase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + n Na+[side 1] = ADP + phosphate + n Na+[side 2]
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