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6.3.1.4: aspartate-ammonia ligase (ADP-forming)

This is an abbreviated version!
For detailed information about aspartate-ammonia ligase (ADP-forming), go to the full flat file.

Reaction

ATP
+
L-aspartate
+
NH3
=
ADP
+
phosphate
+
L-asparagine

Synonyms

Asparagine synthetase, Asparagine synthetase (ADP-forming), Synthetase, asparagine (adenosine diphosphate-forming), Asparagine synthetase (adenosine diphosphate-forming), ASNS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
                6.3.1.4 aspartate-ammonia ligase (ADP-forming)

Inhibitors

Inhibitors on EC 6.3.1.4 - aspartate-ammonia ligase (ADP-forming)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
hydroxylamine
-
above 400 mM
MoO42-
-
-
Na2HAsO4
-
-
p-chloromercuribenzoate
additional information
-
CHOP suppresses the induction of the endogenous ASNS gene and inhibits transcription from a reporter gene driven by the ASNS promoter following activation by ATF4 or amino acid deprivation. The inhibitory effect of CHOP on the ASNS gene is not observed when truncated proteins, encoding either the N- or C-terminal portion of the protein, are expressed, overview
-