6.3.1.4: aspartate-ammonia ligase (ADP-forming)
This is an abbreviated version!
For detailed information about aspartate-ammonia ligase (ADP-forming), go to the full flat file.
Reaction
Synonyms
ASNS, Asparagine synthetase, Asparagine synthetase (adenosine diphosphate-forming), Asparagine synthetase (ADP-forming), Synthetase, asparagine (adenosine diphosphate-forming)
ECTree
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Activating Compound
Activating Compound on EC 6.3.1.4 - aspartate-ammonia ligase (ADP-forming)
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ASNS is induced by ATF4, amino acid deprivation, or ER stress, siRNA-mediated knockdown of CHOP further enhances the induction of ASNS by either amino acid deprivation or ER stress, overview
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additional information
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the unfolded protein response, UPR, pathway is comprised of three signaling cascades, mediated by the ER stress sensor proteins PERK, IRE1, and ATF6, and PERK is responsible for activation of the ASNS, while the IRE1/XBP1 and ATF6 branches of the UPR do not participate in the induction of ASNS transcription, overview
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