6.3.1.4: aspartate-ammonia ligase (ADP-forming)

This is an abbreviated version!
For detailed information about aspartate-ammonia ligase (ADP-forming), go to the full flat file.

Reaction

ATP
+
L-aspartate
+
NH3
=
ADP
+
phosphate
+
L-asparagine

Synonyms

Asparagine synthetase, Asparagine synthetase (ADP-forming), Synthetase, asparagine (adenosine diphosphate-forming), Asparagine synthetase (adenosine diphosphate-forming), ASNS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
                6.3.1.4 aspartate-ammonia ligase (ADP-forming)

Substrates Products

Substrates Products on EC 6.3.1.4 - aspartate-ammonia ligase (ADP-forming)

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + L-Asp + hydroxylamine
ADP + phosphate + beta-aspartylhydroxamate
show the reaction diagram
-
maximal activity at 400 mM NH2OH
-
?
ATP + L-Asp + NH4+
ADP + phosphate + L-Asn
show the reaction diagram
ATP + L-aspartate + NH3
ADP + phosphate + L-asparagine
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
importance of ASNS protein in the cellular mechanisms that confer drug resistance upon the leukemic cells
-
-
?