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6.3.1.4: aspartate-ammonia ligase (ADP-forming)

This is an abbreviated version!
For detailed information about aspartate-ammonia ligase (ADP-forming), go to the full flat file.

Reaction

ATP
+
L-aspartate
+
NH3
=
ADP
+
phosphate
+
L-asparagine

Synonyms

Asparagine synthetase, Asparagine synthetase (ADP-forming), Synthetase, asparagine (adenosine diphosphate-forming), Asparagine synthetase (adenosine diphosphate-forming), ASNS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
                6.3.1.4 aspartate-ammonia ligase (ADP-forming)

Reference

Reference on EC 6.3.1.4 - aspartate-ammonia ligase (ADP-forming)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nair, P.M.
Asparagine synthetase from gamma-irradiated potatoes
Arch. Biochem. Biophys.
133
208-215
1969
Solanum tuberosum
Manually annotated by BRENDA team
AlDawody, A.; Varner, J.E.
Biosynthesis of asparagine
Fed. Proc.
20
10C
1961
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Gjymishka, A.; Su, N.; Kilberg, M.S.
Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway
Biochem. J.
417
695-703
2008
Homo sapiens
Manually annotated by BRENDA team
Su, N.; Kilberg, M.S.
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene
J. Biol. Chem.
283
35106-35117
2008
Homo sapiens
Manually annotated by BRENDA team
Abbatiello, S.E.; Pan, Y.X.; Zhou, M.; Wayne, A.S.; Veenstra, T.D.; Hunger, S.P.; Kilberg, M.S.; Eyler, J.R.; Richards, N.G.; Conrads, T.P.
Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients
J. Proteomics
71
61-70
2008
Homo sapiens
Manually annotated by BRENDA team
Lorenzi, P.L.; Llamas, J.; Gunsior, M.; Ozbun, L.; Reinhold, W.C.; Varma, S.; Ji, H.; Kim, H.; Hutchinson, A.A.; Kohn, E.C.; Goldsmith, P.K.; Birrer, M.J.; Weinstein, J.N.
Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines
Mol. Cancer Ther.
7
3123-3128
2008
Homo sapiens
Manually annotated by BRENDA team
Akagi, T.; Yin, D.; Kawamata, N.; Bartram, C.R.; Hofmann, W.K.; Song, J.H.; Miller, C.W.; den Boer, M.L.; Koeffler, H.P.
Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells
Leuk. Res.
33
991-996
2009
Homo sapiens
Manually annotated by BRENDA team