6.3.1.4: aspartate-ammonia ligase (ADP-forming)

This is an abbreviated version!
For detailed information about aspartate-ammonia ligase (ADP-forming), go to the full flat file.

Reaction

ATP
+
L-aspartate
+
NH3
=
ADP
+
phosphate
+
L-asparagine

Synonyms

Asparagine synthetase, Asparagine synthetase (ADP-forming), Synthetase, asparagine (adenosine diphosphate-forming), Asparagine synthetase (adenosine diphosphate-forming), ASNS

ECTree

     6 Ligases
         6.3 Forming carbon-nitrogen bonds
             6.3.1 Acid—ammonia (or amine) ligases (amide synthases)
                6.3.1.4 aspartate-ammonia ligase (ADP-forming)

Application

Application on EC 6.3.1.4 - aspartate-ammonia ligase (ADP-forming)

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
the first intron of the gene ASNS contains two 14-bp tandem repeat sequences, i.e. 2R. Approximately 75% of acute lymphoblastic leukemia samples have the 2R sequence in both alleles, 20% and 3% acute lymphoblastic leukemia samples have three and four 14-bp tandem repeats in one allele, respectively. The other allele has 2R. The tandem repeat sequence is not specific to the leukemia cells but represents a novel germline polymorphism. The 14-bp sequence functions as a transcriptional enhancer element as shown by reporter analysis and forms a protein-DNA complex in vitro